Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(10), С. 849 - 868

Опубликована: Июль 18, 2024

Язык: Английский

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A Photomodulable Bacteriophage‐Spike Nanozyme Enables Dually Enhanced Biofilm Penetration and Bacterial Capture for Photothermal‐Boosted Catalytic Therapy of MRSA Infections

Advanced Science, Год журнала: 2023, Номер 10(24)

Опубликована: Июнь 13, 2023

Nanozymes, featuring intrinsic biocatalytic effects and broad-spectrum antimicrobial properties, are emerging as a novel antibiotic class. However, prevailing bactericidal nanozymes face challenging dilemma between biofilm penetration bacterial capture capacity, significantly impeding their antibacterial efficacy. Here, this work introduces photomodulable nanozyme (ICG@hMnO

Язык: Английский

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Metal‐Phenolic Nanocapsules with Photothermal Antibacterial and Ros Scavenging Ability for Diabetic Wound Healing

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(10)

Опубликована: Янв. 2, 2024

The presence of bacteria in diabetic wounds not only leads to the formation biofilms but also triggers oxidative stress and inflammatory responses, which hinder wound-healing process. Therefore, it is imperative formulate a comprehensive strategy that can proficiently eliminate enhance wound microenvironment. Herein, this work develops multifunctional metal-phenolic nanozymes (TA-Fe/Cu nanocapsules), wherein one-pot coordination tannic acid (TA)and Fe

Язык: Английский

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Functional probes for the diagnosis and treatment of infectious diseases

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Июнь 25, 2024

Abstract Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for research treatment of infectious diseases. Their applications in realm include pathogen detection, exploration biological mechanisms, development anti‐infective drugs. This review provides a concise introduction severity, classification, pathogenesis Subsequently, we examined distinctiveness design strategies diagnosing treating diseases, shedding light on their rationale using typical examples. We discuss current status associated with clinical implementation probes. Furthermore, explored prospects these diagnosis aims offer novel insights into diagnostic broaden disease treatment.

Язык: Английский

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Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

Small, Год журнала: 2024, Номер 20(10)

Опубликована: Янв. 4, 2024

Abstract Biofilm‐associated infections are one of the most challenging healthcare threats for humans, accounting 80% bacterial infections, leading to persistent and chronic infections. The conventional antibiotics still face their dilemma poor therapeutic effects due high tolerance resistance led by biofilm barriers. Nanotechnology‐based antimicrobials, nanoparticles (NPs), paid attention extensively considered as promising alternative. This review focuses on whole journey NPs against biofilm‐associated clarify it clearly, is divided into four processes in sequence 1) Targeting biofilms, 2) Penetrating barrier, 3) Attaching cells, 4) Translocating through cell envelope. Through outlining compositions properties biofilms bacteria recent advances present strategies each process comprehensively discussed combat well combined these with drug resistance, aiming guide rational design facilitate wide application

Язык: Английский

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Recent Progress and Prospect of Metal–Organic Framework-Based Nanozymes in Biomedical Application

Nanomaterials, Год журнала: 2024, Номер 14(3), С. 244 - 244

Опубликована: Янв. 23, 2024

A nanozyme is a nanoscale material having enzyme-like properties. It exhibits several superior properties, including low preparation cost, robust catalytic activity, and long-term storage at ambient temperatures. Moreover, high stability enables repetitive use in multiple reactions. Hence, it considered potential replacement for natural enzymes. Enormous research interest nanozymes the past two decades has made imperative to look better enzyme-mimicking materials biomedical applications. Given this, on metal–organic frameworks (MOFs) as gained momentum. MOFs are advanced hybrid of inorganic metal ions organic ligands. Their distinct composition, adaptable pore size, structural diversity, ease tunability physicochemical properties enable mimic activities act promising candidates. This review aims discuss recent advances development MOF-based (MOF-NZs) highlight their applications field biomedicine. Firstly, different enzyme-mimetic exhibited by discussed, insights given into various strategies achieve them. Modification functionalization deliberated obtain MOF-NZs with enhanced activity. Subsequently, biosensing therapeutics domain discussed. Finally, concluded giving challenges encountered possible directions overcome them future. With this review, we aim encourage consolidated efforts across enzyme engineering, nanotechnology, science, biomedicine disciplines inspire exciting innovations emerging yet field.

Язык: Английский

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Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 16011 - 16028

Опубликована: Март 26, 2024

Superbug infections and transmission have become major challenges in the contemporary medical field. The development of novel antibacterial strategies to efficiently treat bacterial conquer problem antimicrobial resistance (AMR) is extremely important. In this paper, a bimetallic CuCo-doped nitrogen–carbon nanozyme-functionalized hydrogel (CuCo/NC-HG) has been successfully constructed. It exhibits photoresponsive-enhanced enzymatic effects under near-infrared (NIR) irradiation (808 nm) with strong peroxidase (POD)-like oxidase (OXD)-like activities. Upon NIR irradiation, CuCo/NC-HG possesses photodynamic activity for producing singlet oxygen(1O2), it also high photothermal conversion effect, which not only facilitates elimination bacteria but improves efficiency reactive oxygen species (ROS) production accelerates consumption GSH. shows lower hemolytic rate better cytocompatibility than CuCo/NC positive charge macroporous skeleton restricting negatively charged range ROS destruction, strengthening efficiency. Comparatively, stronger bactericidal ability against methicillin-resistant Staphylococcus aureus (MRSA) ampicillin-resistant Escherichia coli (AmprE. coli) through destroying cell membranes negligible occurrence AMR. More importantly, plus can exhibit satisfactory performance absence H2O2, avoiding toxicity from high-concentration H2O2. vivo evaluation conducted using mouse wound infection model histological analyses, results show that upon suppress promote healing, without causing inflammation tissue adhesions.

Язык: Английский

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Engineering Platelet Membrane‐Coated Bimetallic MOFs as Biodegradable Nanozymes for Efficient Antibacterial Therapy

Small, Год журнала: 2023, Номер 20(23)

Опубликована: Дек. 27, 2023

Abstract Nanocatalytic‐based wound therapeutics present a promising strategy for generating reactive oxygen species (ROS) to antipathogen promote healing. However, the full clinical potential of these nanocatalysts is limited by their low reactivity, targeting ability, and poor biodegradability in microenvironment. Herein, bio‐organic nanozyme developed encapsulating FeZn‐based bimetallic organic framework (MOF) (MIL‐88B‐Fe/Zn) platelet membranes (PM@MIL‐88B‐Fe/Zn) antimicrobial activity during The introduction Zn MIL‐88B‐Fe/Zn modulates electronic structure Fe thus accelerating catalytic kinetics its peroxidase‐like catalytically generate powerful ROS. membrane coating MOF innovatively enhanced interaction between nanoparticles biological environment, further developing bacterial‐targeted therapy with excellent antibacterial against both gram‐positive gram‐negative bacteria. Furthermore, this markedly suppressed levels inflammatory cytokines promoted angiogenesis vivo effectively treat skin surface wounds accelerate PM@MIL‐88B‐Fe/Zn exhibited superior biodegradability, favourable metabolism non‐toxic accumulation, eliminating concerns regarding side effects from long‐term exposure. high features, nanoenzymes study provide useful insights into design synthesis nanocatalysts/nanozymes practical biomedical applications.

Язык: Английский

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Artificial Phages with Biocatalytic Spikes for Synergistically Eradicating Antibiotic‐Resistant Biofilms

Advanced Materials, Год журнала: 2024, Номер 36(32)

Опубликована: Июнь 5, 2024

Antibiotic-resistant pathogens have become a global public health crisis, especially biofilm-induced refractory infections. Efficient, safe, and biofilm microenvironment (BME)-adaptive therapeutic strategies are urgently demanded to combat antibiotic-resistant biofilms. Here, inspired by the fascinating biological structures functions of phages, de novo design spiky Ir@Co

Язык: Английский

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ROS‐Responsive Core‐Shell Microneedles Based on Simultaneous Efficient Type I/II Photosensitizers for Photodynamic Against Bacterial Biofilm Infections

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract Antimicrobial photodynamic therapy (aPDT) has emerged as an appealing therapeutic option against biofilm infections. However, effectively penetrating the dense barrier of and anchoring bacteria to achieve elimination wound healing under hypoxic environments remains a challenge for aPDT. Herein, three type I/II Hypocrellin B (HB)‐cationic photosensitizers (HB‐P, HB‐TP, HB‐TTP) are designed based on multi‐cationic long chains molecular engineering strategy. With increasing number introduced cations, reactive oxygen species (ROS) production bacterial‐anchoring abilities HB‐cationic greatly enhanced. Notably, HB‐TTP demonstrates higher aPDT activity broad‐spectrum antibacterial properties. Furthermore, address conundrum biofilm‐infected wounds, ROS‐responsive core‐shell microneedle (HB‐TTP&EGF@MN) is by biphasically integrating growth factor. When penetrates biofilm, shell quickly dissolves releases removal laser irradiation. The core subsequently degraded slowly in presence endogenous ROS within wound, facilitating sustained release factor promote tissue regeneration. This work not only provides effective strategy rational design efficient antimicrobial agents but also proposes innovative ideas development controlled‐release pharmaceutical materials synergize

Язык: Английский

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