Advancing therapeutic efficacy: nanovesicular delivery systems for medicinal plant-based therapeutics

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(10), С. 7229 - 7254

Опубликована: Май 3, 2024

Язык: Английский

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Polymer vesicles as nanoreactors for biomedical applications

Precision medicine and engineering., Год журнала: 2024, Номер 1(1), С. 100004 - 100004

Опубликована: Авг. 13, 2024

The vesicle, which consists of the cytoplasm encapsulated by lipid bilayer, has acted as an important mediator intercellular communication a potential tool for disease treatment during past decade. In addition to ability biological amphiphiles form vesicles, artificial vesicles can also be formed from synthetic polymers, have been widely applied in transport, temporary storage and chemical reaction chambers. this review, we summarized progress use polymer nanoreactors biomedical applications. First, various preparation methods, including hydration, polymerization-induced self-assembly, solvent exchange, emulsion phase transfer, microfluidics flash nanoprecipitation, are compared here. Second, applications nanoreactors, such stimuli-responsive drug delivery, blood–brain barrier penetration, enhanced physiological stability, diseases, highlighted review. addition, existing obstacles future development directions proposed broader clinical translations.

Язык: Английский

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Biomimetic Nanoparticles for Basic Drug Delivery

Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1306 - 1306

Опубликована: Окт. 7, 2024

Biomimetic nanoparticles (BMNPs) are innovative nanovehicles that replicate the properties of naturally occurring extracellular vesicles, facilitating highly efficient drug delivery across biological barriers to target organs and tissues while ensuring maximal biocompatibility minimal-to-no toxicity. BMNPs can be utilized for therapeutic payloads imparting novel other nanotechnologies based on organic inorganic materials. The application specifically modified membranes coating has potential enhance their efficacy biocompatibility, presenting a promising pathway advancement technologies. This manuscript is grounded in fundamentals biomimetic technologies, offering comprehensive overview analytical perspective preparation functionalization BMNPs, which include cell membrane-coated (CMCNPs), artificial cell-derived vesicles (ACDVs), fully synthetic (fSVs). review examines both "top-down" "bottom-up" approaches nanoparticle preparation, with particular focus techniques such as membrane coating, cargo loading, microfluidic fabrication. Additionally, it addresses technological challenges solutions associated large-scale production clinical related

Язык: Английский

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Al-Based Metal–Organic Nanoslice-Coupled Phospholipid Layer Enables Highly Enriched Biological External Vesicles

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Systematic analysis of the information content biological external vesicles (BEVs) is essential for understanding complex relationships between metabolic processes and cells at a systemic level. Although considerable efforts have been made to enrich BEVs, their comprehensive in way that maintains stabilizes maintenance high doses remains challenge. To address this issue, we developed metal–organic nanoslice-coupled exocytosis phospholipid layer method utilized subtle interactions nanoslice molecular membrane achieve convenient efficient enrichment BEVs. The bypassed conventional ultracentrifugation size exclusion separation helped highly preserve internal on By integrating analyzing enriched BEVs elements such as proteins endotoxins, simplicity robustness vesicle surface technology were verified, which provided reliable platform studying cellular events associated with outer expanded applications nanoslice.

Язык: Английский

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Transethosomal System for Enhanced Dermal Delivery of Clindamycin

BioNanoScience, Год журнала: 2025, Номер 15(2)

Опубликована: Фев. 7, 2025

Язык: Английский

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Nanoscience in Action: Unveiling Emerging Trends in Materials and Applications

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Since their inception in the early 1960s, use of nanoscale materials has progressed leaps and bounds, role diverse fields ranging from human health to energy is undeniable. In this report, we utilize CAS Content Collection, a vast repository scientific information extracted journals patent publications, identify emerging topics field. This involves understanding trends, such as growth certain over time, well establishing relationships among topics. We achieved by using host strategies including quantitative natural language processing (NLP) approach 270 subtopics across three major categories-materials, applications, properties-by surveying 3 million documents spanning two decades nanoscience landscape. wealth been condensed into several conceptual Trendscape maps other data visualizations, providing metrics related identified concepts, grouped hierarchical classes, connections between them have explored. Our extensive analysis taking advantage an NLP-based along with robust indexing provides valuable insights field that hope can help inform drive future research efforts. series interconnected papers, will present our findings project, focus on four applications materials-drug delivery, sensors, energy, catalysis-to provide more comprehensive detailed picture nanotechnology these fields.

Язык: Английский

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Fused exosomal targeted therapy in periprosthetic osteolysis through regulation of bone metabolic homeostasis

Bioactive Materials, Год журнала: 2025, Номер 50, С. 171 - 188

Опубликована: Апрель 8, 2025

Язык: Английский

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Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 8, 2025

The critical role of the immune system in brain function and dysfunction is well recognized, yet development therapies for psychiatric diseases has been slow due to concerns about iatrogenic deficiencies. These are emphasized by lack objective diagnostic tools psychiatry. A promise resolve this conundrum lies exploitation extracellular vesicles (EVs) that physiologically produced or can be synthetized. EVs regulate recipient cell functions offer potential EVs-based therapies. Intranasal administration enables targeting specific regions functions, thereby facilitating design precise treatments diseases. such requires navigating four dynamically interacting networks: neuronal, glial, immune, EVs. networks profoundly influenced fluid distribution. They crucial homeostasis, cellular intercellular communication. Fluid abnormalities, like edema altered cerebrospinal (CSF) dynamics, disrupt these networks, negatively impacting health. deeper understanding above-mentioned vital creating biomarker panels identify distinct patient subsets with similar neuro-behavioral symptoms. Testing functional pathways biomarkers could lead new therapeutic tools. Regulatory approval will depend on robust preclinical data reflecting progress interdisciplinary areas, which pave way innovative treatments. Highly collaborative teams needed achieve ambitious goals.

Язык: Английский

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Cell membrane and extracellular vesicle membrane‐coated nanoparticles: An envisaged approach for the management of skin conditions

View, Год журнала: 2024, Номер unknown

Опубликована: Окт. 29, 2024

Abstract Cell membrane‐coated biomimetic nanosystems have been recognized as promising drug delivery vehicles in recent years for the management of diverse skin conditions. Nanoparticles (NPs) coated with biomembranes, derived from either cell membranes or subcellular structures (e.g., extracellular vesicles), offer an opportunity to combine biological interfacial characteristics coating alongside internal core component at nanoscale. The enhances biocompatibility NPs and their interaction skin, improving affinity, contact, retention. This also enables controlled release drugs provides skin‐targeting capabilities, which collectively improve effectiveness, safety, stability topical transdermal formulations. In this context, current review delves into progress using therapeutics. Specifically, it examines various types coatings, including origins, heterogeneous functions, surface molecular repertoires, great detail. Additionally, presents methods preparing characterizing biomimetic‐coated NPs. Furthermore, potential bioinspired treating a range skin‐related conditions has meticulously explored. Last, toxicological aspects these thoroughly examined provide thorough summary evolution applications.

Язык: Английский

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Targeted Ferroptosis-Immunotherapy Synergy: Enhanced Antiglioma Efficacy with Hybrid Nanovesicles Comprising NK Cell-Derived Exosomes and RSL3-Loaded Liposomes

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28193 - 28208

Опубликована: Май 22, 2024

Ferroptosis therapy and immunotherapy have been widely used in cancer treatment. However, nonselective induction of ferroptosis tumors is prone to immunosuppression, limiting the therapeutic effect To address this issue, study reports a customized hybrid nanovesicle composed NK cell-derived extracellular versicles RSL3-loaded liposomes (hNRVs), aiming establish positive cycle between immunotherapy. Thanks enhanced permeability retention tumor homing characteristics exosomes, our data indicate that hNRVs can actively accumulate enhance cellular uptake. FASL, IFN-γ, RSL3 are released into microenvironment, where FASL derived from cells effectively lyses cells. downregulates expression GPX4 tumor, leading accumulation LPO ROS, promotes The IFN-γ TNF-α stimulates maturation dendritic induces inactivation GPX4, promoting lipid peroxidation, making them sensitive indirectly occurrence ferroptosis. This highlights role hNRV platform enhancing effectiveness synergistic treatment with selective delivery inducers immune activation against glioma without causing additional side effects on healthy organs.

Язык: Английский

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