Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Human
cells,
such
as
fibroblasts
and
particularly
human
mesenchymal
stem
cells
(hMSCs),
represent
a
promising
effective
therapeutic
tool
for
range
of
cell-based
therapies
used
to
treat
various
diseases.
The
delivery
remains
challenge
due
limitations
in
targeting,
invasiveness,
cell
viability.
To
address
these
challenges,
we
developed
microneedle
(MN)
system
minimally
invasive
with
high
cellular
stability.
MN
comprises
core
gelatin
methacryloyl
(GelMA)
hydrogel
embedded
fibroblasts,
encased
polylactic-co-glycolic
acid
(PLGA)
shell
that
enhances
structural
integrity
efficient
skin
penetration.
fabrication
process
involves
UV-crosslinking
the
GelMA
optimizing
both
encapsulation
strength.
This
achieves
over
80%
viability
after
seven
days
vitro,
conventional
formulation
providing
superior
stability
outcomes.
platform's
ability
ensure
sustained
presents
implications
future
applications
regenerative
medicine,
wound
healing,
localized
treatments
conditions.
opens
new
avenues
therapies,
offering
versatile
scalable
solution
delivery.
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 6, 2025
Abstract
The
use
of
microneedles
(MNs)
has
been
established
as
an
effective
transdermal
drug
delivery
strategy
that
extensively
deployed
for
treating
various
diseases,
including
skin
diseases.
MNs
can
surpass
the
constraints
conventional
methods
by
their
superior
safety
and
efficacy
through
precise
targeting,
while
simultaneously
enabling
painless
delivery.
Currently,
are
increasingly
used
carriers
delivery,
with
loading
insoluble
drugs
to
improve
treatment
efficiency
or
combining
bioactive
substances
construction
efficient
system
maximize
effects
substances.
preparation
diverse,
them
meet
requirements
most
applications.
emergence
addressed
shortcomings
associated
drugs,
expanded
applications
substances,
improved
in
clinical
practice.
This
review
summarizes
current
information
on
application
a
variety
such
psoriasis,
vitiligo,
alopecia,
hypertrophic
scarring,
atopic
dermatitis,
melanoma,
acne,
infections.
future
opportunities
diseases
also
discussed.
Despite
substantial
progress
vectors,
issues
low
poor
mechanical
strength
during
remain
main
challenges.
Therefore,
implementation
MNs-based
therapies
remains
limited,
highlighting
key
research.
Microneedles
have
emerged
as
a
promising
platform
for
transdermal
drug
delivery
with
prominent
advantages,
such
enhanced
permeability,
mitigated
pain,
and
improved
patient
adherence.
While
microneedles
primarily
been
employed
delivering
small
molecules,
nucleic
acids,
peptides,
proteins,
recent
researches
demonstrated
their
prospect
in
combination
cell
therapy.
Cell
therapy
involving
administration
or
transplantation
of
living
cells
(e.g.
T
cells,
stem
pancreatic
cells)
has
gained
significant
attention
preclinical
clinical
applications
various
disease
treatments.
However,
the
effectiveness
systemic
may
be
restricted
localized
conditions
like
solid
tumors
skin
disorders
due
to
limited
penetration
accumulation
into
lesions.
In
this
perspective,
an
overview
advances
microneedle-assisted
immunotherapy,
tissue
regeneration,
hormone
modulation,
respect
mechanical
property,
loading
capacity,
well
viability
bioactivity
loaded
is
provided.
Potential
challenges
future
perspectives
microneedle-mediated
are
also
discussed.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 17, 2024
As
a
transdermal
drug
delivery
method,
microneedles
offer
minimal
invasiveness,
painlessness,
and
precise
in-situ
treatment.
However,
current
rely
on
passive
diffusion,
leading
to
uncontrollable
penetration.
To
overcome
this,
we
developed
pneumatic
microneedle
patch
that
uses
live
Enterobacter
aerogenes
as
microengines
actively
control
delivery.
These
microbes
generate
gas,
driving
drugs
into
deeper
tissues,
with
adjustable
glucose
concentration
allowing
over
the
process.
Our
results
showed
this
microorganism-powered
system
increases
depth
by
200%,
reaching
up
1000
μm
below
skin.
In
psoriasis
animal
model,
technology
effectively
delivered
calcitriol
subcutaneous
offering
rapid
symptom
relief.
This
innovation
addresses
limitations
of
conventional
microneedles,
enhancing
efficiency,
permeability,
introducing
creative
paradigm
for
on-demand
controlled
Journal of Tissue Engineering,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 1, 2025
Osteonecrosis
of
the
femoral
head
(ONFH)
is
a
prevalent
orthopedic
disorder
characterized
primarily
by
compromised
blood
supply.
This
vascular
deficit
results
in
cell
apoptosis,
trabecular
bone
loss,
and
structural
collapse
at
late
stage,
significantly
impairing
joint
function.
While
MRI
highly
effective
tool
for
diagnosing
ONFH
its
early
stages,
challenges
remain
due
to
limited
availability
high
cost
MRI,
as
well
absence
routine
screening
asymptomatic
patients.
.
In
addition,
current
therapeutic
strategies
predominantly
only
relieve
symptoms
while
disease-modifying
drugs
are
still
under
investigation/development.
Considering
that
supply
plays
key
role
pathology
ONFH,
angiogenic
therapies
have
been
put
forward
promising
treatment
options.
Emerging
bioengineering
interventions
targeting
angiogenesis
hold
potential
treatment.
this
review,
we
introduce
advances
research
into
summarize
novel
angiogenesis.
review
sheds
light
upon
new
directions
future
ONFH.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Integrin
and
focal
adhesion
can
regulate
cytoskeleton
distribution
to
govern
actin-related
force
remodeling
play
an
important
role
in
nuclear
configuration
force-sensing
mechanotransduction
of
stem
cells.
However,
further
exploration
the
interaction
between
actinin
complex
myosin,
kinetics,
molecular
mechanism
structures
nucleate
within
engineered
cells
is
vague.
An
extensive
comprehension
cell
morphogenesis,
remodeling,
essential
reveal
basic
physical
principles
polymerization
force-related
signaling
delivery.
Advanced
microarrays
are
designed
determine
heterogeneous
morphology
behaviors
The
heterogeneity
from
transferred
into
nuclei
by
evaluation
Lamins,
YAP,
BrdU
expression.
Tuning
activation
proteins
nucleators
adjust
mechanics
may
be
underlying
change
response
its
physiological
microarrayed
Advanced Materials,
Год журнала:
2024,
Номер
36(41)
Опубликована: Авг. 16, 2024
Abstract
Bioorthogonal
chemistry
has
provided
an
elaborate
arsenal
to
manipulate
native
biological
processes
in
living
systems.
As
the
great
advancement
of
nanotechnology
recent
years,
bioorthogonal
nanozymes
are
innovated
tackle
challenges
that
emerged
practical
biomedical
applications.
uniquely
positioned
owing
their
advantages
high
customizability
and
tunability,
as
well
good
adaptability
systems,
which
bring
exciting
opportunities
for
More
intriguingly,
offers
opportunity
innovating
catalytic
materials.
In
this
comprehensive
review,
significant
progresses
discussed
with
both
spatiotemporal
controllability
performance
highlight
design
principles
rapid
The
remaining
future
perspectives
then
outlined
along
thriving
field.
It
is
expected
review
will
inspire
promote
novel
nanozymes,
facilitate
clinical
translation.
