Multifunctional Nanofiber Membranes Constructed by Microfluidic Blow-Spinning to Inhibit Scar Formation at Early Intervention Stage DOI
S.H. Wen,

Hanqiang Zhao,

Ying Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(39), P. 53042 - 53059

Published: Sept. 19, 2024

Pathological scarring has been a challenge in skin injury repair since ancient times, and prophylactic treatment the early stages of wound healing usually results delayed healing. In this study, poly(ethylene oxide) (PEO) chitosan (CTS) were used as carrier materials to construct multifunctional pirfenidone (PFD)/CTS/PEO (PCP) nanofiber membranes (NFMs) loaded with PFD by microfluidic blow-spinning (MBS). MBS is good method for quickly, safely, greenly constructing large-area manufacturing inexpensive NFMs. PCP NFMs uniform external morphology, diameters ranging from 200 500 nm. The encapsulation efficiency drug-loaded was above 80%, which had slow release, visualization, water absorption, biocompatibility. inhibitory effect on normal human dermal fibroblasts dose-dependent inhibited expression transforming growth factor-β1/SMAD family member 3 (TGF-β1/SMAD3) signaling pathway. showed significant antibacterial effects against both

Language: Английский

Core‐Shell Gel Nanofiber Scaffolds Constructed by Microfluidic Spinning toward Wound Repair and Tissue Regeneration DOI Creative Commons

Yue Dong,

Zongkun Ding,

Yuting Bai

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(39)

Published: July 15, 2024

Abstract Growing demand for wound care resulting from the increasing chronic diseases and trauma brings intense pressure to global medical health service system. Artificial skin provides mechanical microenvironmental support wound, which is crucial in healing tissue regeneration. However, challenges still remain clinical application of artificial since lack synergy effect necessary performance. In this study, a multi‐functional fabricated through microfluidic spinning technology by using core‐shell gel nanofiber scaffolds (NFSs). This strategy can precisely manipulate microstructure under microscale. The as‐prepared demonstrates superior characteristics including surface wettability, breathability, high strength, strain sensitivity, biocompatibility biodegradability. Notably, has capability deliver medications controlled sustained manner, thereby accelerating process. innovative approach paves way development new generation introduces novel concept structural design unique NFSs.

Language: Английский

Citations

7
Advances in medical devices using nanomaterials and nanotechnology: Innovation and regulatory science DOI

Chubing Lin,

Xin Huang, Yueguang Xue

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 353 - 369

Published: Feb. 20, 2025

Language: Английский

Citations

0
Functionalized gelatin/poly(l-lactide-co-ε-caprolactone) fibrous membrane promotes scarless wound healing by modulating inflammation and reducing fibrosis DOI

Jing Wen,

Shue Jin, Xue Luo

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141785 - 141785

Published: March 5, 2025

Language: Английский

Citations

0
Microfluidic Construction of Heterogeneous Micro–Nano-Structured Materials for Biomedical Applications DOI
Xiaowei Yang, Chaojing Li,

Yongjie Jiao

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1462 - 1487

Published: March 20, 2025

Language: Английский

Citations

0
A Multifunctional Nanocomplex as miRNA/Antibiotic Co‐Delivery System Based on Tetrahedral Framework DNA: Application to Infected Wound Healing DOI
Xiaoying Lyu,

Haoyan Wu,

Ye Chen

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Infected wounds are a complex disease involving bacterial infections and dysregulated inflammation. However, current research has mostly focused on inhibition rather than Thus, combined therapeutic strategies with anti‐bacterial anti‐inflammation efficacies urgently needed. Antibiotics the main treatment strategy for infections. excessive use of antibiotics throughout body can cause serious side effects. In addition, miRNA‐based therapeutics superior wounds, but their rapid degradation poor cellular uptake limit clinical application. Tetrahedral framework DNA (tFNA) is an ideal drug delivery system owing to its excellent stability remarkable transport ability. Herein, novel multi‐functional miRNA antibiotic co‐delivery based tFNA presented first time, called B/L. B/L heightened resistance serum codelivery After transdermal administration, specifically target TNF receptor‐associated factor 6(TRAF6) IL‐1receptor‐associated kinase 1(IRAK1), thereby regulating nuclear kappa‐B (NF‐𝜿B) thus effectively reducing inflammation promoting healing infected wounds. This provides versatile, simple, biocompatible, powerful platform personalized multiple diseases.

Language: Английский

Citations

3
Electrical Microneedles for Wound Treatment DOI Creative Commons
Yu Wang, Lijun Cai, Fan Lü

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Electrical stimulation has been hotpot research and provoked extensive interest in a broad application such as wound closure, tissue injury repair, nerve engineering. In particular, immense efforts have dedicated to developing electrical microneedles, which demonstrate unique features terms of controllable drug release, real-time monitoring, therapy, thus greatly accelerating the process healing. Here, review state-of-art concerning microneedles applied for treatment is presented. After comprehensive analysis mechanisms on healing, derived three types are clarified summarized. Further, their applications healing highlighted. Finally, current perspectives directions development future improving addressed.

Language: Английский

Citations

1
Multifunctional Nanofiber Membranes Constructed by Microfluidic Blow-Spinning to Inhibit Scar Formation at Early Intervention Stage DOI
S.H. Wen,

Hanqiang Zhao,

Ying Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(39), P. 53042 - 53059

Published: Sept. 19, 2024

Pathological scarring has been a challenge in skin injury repair since ancient times, and prophylactic treatment the early stages of wound healing usually results delayed healing. In this study, poly(ethylene oxide) (PEO) chitosan (CTS) were used as carrier materials to construct multifunctional pirfenidone (PFD)/CTS/PEO (PCP) nanofiber membranes (NFMs) loaded with PFD by microfluidic blow-spinning (MBS). MBS is good method for quickly, safely, greenly constructing large-area manufacturing inexpensive NFMs. PCP NFMs uniform external morphology, diameters ranging from 200 500 nm. The encapsulation efficiency drug-loaded was above 80%, which had slow release, visualization, water absorption, biocompatibility. inhibitory effect on normal human dermal fibroblasts dose-dependent inhibited expression transforming growth factor-β1/SMAD family member 3 (TGF-β1/SMAD3) signaling pathway. showed significant antibacterial effects against both

Language: Английский

Citations

0