Angewandte Chemie,
Год журнала:
2023,
Номер
135(51)
Опубликована: Ноя. 4, 2023
Abstract
Molecular
carbons
(MCs)
are
molecular
cutouts
of
carbon
materials.
Doping
with
heteroatoms
and
constructing
open‐shell
structures
two
powerful
approaches
to
achieve
unexpected
unique
properties
MCs.
Herein,
we
disclose
a
new
strategy
design
boron‐doped
MCs
(BMCs),
namely
by
pentagon‐fusion
an
organoborane
π‐system.
We
synthesized
diradicaloid
BMC
molecules
that
feature
C
24
B
38
π‐skeletons
containing
pentagonal
ring.
A
thorough
investigation
reveals
such
not
only
leads
their
local
antiaromaticity,
but
also
incorporates
internal
quinoidal
substructure
thereby
induces
singlet
diradical
states.
Moreover,
fully
fused
enable
efficient
π
conjugation,
which
is
expanded
over
the
whole
frameworks.
Consequently,
some
intriguing
physical
achieved,
as
narrow
energy
gaps,
very
broad
light
absorptions,
superior
photothermal
capability,
along
excellent
photostability.
Notably,
solid
molecule
exhibits
absorption
covers
range
300–1200
nm
efficiency
93.5
%
for
solar‐driven
water
evaporation,
thus
demonstrating
potential
BMCs
high‐performance
organic
ACS Nano,
Год журнала:
2024,
Номер
18(5), С. 4089 - 4103
Опубликована: Янв. 25, 2024
To
meet
the
requirements
of
biomedical
applications
in
antibacterial
realm,
it
is
great
importance
to
explore
nano-antibiotics
for
wound
disinfection
that
can
prevent
development
drug
resistance
and
possess
outstanding
biocompatibility.
Therefore,
we
attempted
synthesize
an
atomically
dispersed
ion
(Fe)
on
phenolic
carbon
quantum
dots
(CQDs)
combined
with
organic
photothermal
agent
(PTA)
(Fe@SAC
CQDs/PTA)
via
a
hydrothermal/ultrasound
method.
Fe@SAC
CQDs
adequately
exerted
peroxidase-like
activity
while
PTA
presented
excellent
conversion
capability,
which
provided
enormous
potential
applications.
Based
our
work,
CQDs/PTA
exhibited
eradication
Escherichia
coli
(>99%
inactivation
efficiency)
Staphylococcus
aureus
based
synergistic
chemodynamic
therapy
(CDT)
(PTT).
Moreover,
vitro
experiments
demonstrated
could
inhibit
microbial
growth
promote
bacterial
biofilm
destruction.
In
vivo
suggested
CQDs/PTA-mediated
CDT
PTT
promotion
recovery
effects.
This
work
indicated
serve
as
broad-spectrum
antimicrobial
nano-antibiotic,
was
simultaneously
beneficial
eradication,
disinfection,
healing.
Abstract
Phototherapeutic
nanoplatforms
that
combine
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
with
the
guidance
of
photoacoustic
(PA)
imaging
are
an
effective
strategy
for
treatment
tumors,
but
establishing
a
universal
method
this
has
been
challenging.
In
study,
we
present
supramolecular
assembly
based
on
Förster
resonance
energy
transfer
to
construct
nanostructured
phototherapeutic
agent
(PcDA)
via
anion
cation
interaction
between
two
water‐soluble
phthalocyanine
ramifications,
PcD
PcA.
This
approach
promotes
absorption
energy,
thus
enhancing
generation
reactive
oxygen
species
(ROS)
heat
by
PcDA,
improving
its
therapeutic
efficacy,
overcoming
low
photon
utilization
efficiency
conventional
PSs.
Notably,
after
intravenous
injection
neoplastic
sites
could
be
clearly
visualized
using
PA
imaging,
signal‐to‐liver
ratio
as
high
11.9.
Due
these
unique
features,
PcDA
exhibits
excellent
antitumor
efficacy
in
preclinical
model
at
dose
light
irradiation.
study
offers
general
development
efficient
agents
simultaneous
effect
PDT
PTT
against
tumors
assistance
imaging.
ACS Nano,
Год журнала:
2024,
Номер
18(36), С. 25144 - 25154
Опубликована: Авг. 27, 2024
Near-infrared
II
(NIR-II)
imaging
and
photothermal
therapy
hold
tremendous
potential
in
precision
diagnosis
treatment
within
biological
organisms.
However,
a
significant
challenge
is
the
shortage
of
NIR-II
fluorescent
probes
with
both
high
conversion
coefficient
(PCE)
fluorescence
quantum
yield
(Φ
Abstract
Organic
donor‐acceptor
semiconductors
exhibit
great
potential
in
photothermal
conversion.
However,
it
is
still
challenging
to
achieve
pure
organic
materials
with
broad
absorption
comparable
inorganic
such
as
graphene.
Herein,
two
D‐A‐D
type
DPA‐BT‐O
4
and
NDI‐TPA‐O
three
D‐A‐π‐A‐D
Th‐O
,
Th
2
‐O
IDT‐O
were
readily
prepared
via
high‐yield
steps
simple
air
oxidization.
The
stability
can
be
attributed
their
multiple
resonance
structures
based
on
the
aromatic
nitric
acid
radical
mechanism.
Compared
radicals,
conjugation
extension
of
radicals
endows
them
a
narrowed
band
gap
powder.
Interestingly,
powder
aggregation‐induced
effect
exhibits
between
300
2500
nm,
which
graphene
other
materials.
Under
irradiation
0.9
W/cm
(808
nm),
temperature
rises
250°C
within
60
s.
water
evaporation
conversion
efficiency
94.38
%
an
rate
1.365
kg/m
h
−1
under
one
sun
illumination
achieved.
stands
most
efficient
among
rational
design
strategy.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(51)
Опубликована: Ноя. 4, 2023
Molecular
carbons
(MCs)
are
molecular
cutouts
of
carbon
materials.
Doping
with
heteroatoms
and
constructing
open-shell
structures
two
powerful
approaches
to
achieve
unexpected
unique
properties
MCs.
Herein,
we
disclose
a
new
strategy
design
boron-doped
MCs
(BMCs),
namely
by
pentagon-fusion
an
organoborane
π-system.
We
synthesized
diradicaloid
BMC
molecules
that
feature
C24
B
C38
π-skeletons
containing
pentagonal
ring.
A
thorough
investigation
reveals
such
not
only
leads
their
local
antiaromaticity,
but
also
incorporates
internal
quinoidal
substructure
thereby
induces
singlet
diradical
states.
Moreover,
fully
fused
enable
efficient
π
conjugation,
which
is
expanded
over
the
whole
frameworks.
Consequently,
some
intriguing
physical
achieved,
as
narrow
energy
gaps,
very
broad
light
absorptions,
superior
photothermal
capability,
along
excellent
photostability.
Notably,
solid
molecule
exhibits
absorption
covers
range
300-1200
nm
efficiency
93.5
%
for
solar-driven
water
evaporation,
thus
demonstrating
potential
BMCs
high-performance
organic
ACS Nano,
Год журнала:
2024,
Номер
18(41), С. 28178 - 28188
Опубликована: Окт. 3, 2024
Conjugated
polymers
are
becoming
popular
near-infrared
II
(NIR-II)
phototheranostic
agents
(PTAs)
due
to
their
numerous
advantages,
such
as
high
photostability,
large
molar
extinction
coefficients,
and
excellent
photothermal
properties.
However,
the
strong
π-π
interactions
between
chains
of
conjugated
resulted
in
generally
low
NIR-II
emission
quantum
yields
(QY).
Therefore,
synthesis
with
QY
is
an
interesting
but
challenging
task.
Herein,
we
proposed
a
spacer
twisting
strategy
realize
ultrabright
polymer
nanoparticles
for
fluorescence
imaging-guided
tumor
phototheranostics.
Theoretical
calculations
indicated
that
PY-IT
has
largest
dihedral
angle
largely
π-conjugated
skeleton
spacer,
which
can
effectively
inhibit
intermolecular
stacking,
resulting
improved
16.5%
nanoparticles.
In
addition,
NPs
perform
imaging
treatment
tumors.
The
work
presents
some
valuable
guides
achieving
polymeric
PTAs
QY.
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
8(4), С. 2054 - 2061
Опубликована: Янв. 17, 2025
Diketopyrrolopyrrole
(DPP)
is
now
widely
used
in
the
phototherapy
of
tumors,
but
most
reported
DPP
molecules
have
no
absorption
near-infrared
(NIR)
region.
In
this
study,
3
derivatives
with
donor–acceptor–donor
(D-A-D)
structures
were
designed
and
synthesized,
which
named
OODPP,
OSDPP,
SSDPP
according
to
number
thione
groups.
Their
spectra
are
gradually
red-shifted
an
increase
However,
after
preparation
nanoparticles
(NPs),
OSDPP
NPs
show
maximum
red
shift
peak
at
786
nm
excellent
photothermal
performance
under
NIR
laser
irradiation.
addition,
could
more
effectively
inhibit
tumor
growth
Therefore,
work
provides
a
feasible
method
for
design
DPP-based
phototherapeutic
agents
therapy.
