Macromolecular Chemistry and Physics,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 30, 2024
Abstract
Diabetic
foot
ulcer
has
become
a
heavy
burden
to
the
healthcare
system
with
high
and
growing
incidence
of
diabetes.
Persistent
bacterial
infections
in
diabetic
wounds
can
lead
chronic
inflammation
delayed
wound
healing.
To
address
these
challenges,
dual‐crosslinked
antibacterial
hydrogel
loaded
anti‐inflammatory
compound
asiaticoside
is
developed
this
study.
The
demonstrated
suitable
gelation
properties,
good
biocompatibility,
exceptional
activity.
In
model
on
rats,
asiaticoside‐loaded
alleviate
inflammation,
promote
angiogenesis,
accelerate
Therefore,
shows
considerable
potential
for
The International Journal of Lower Extremity Wounds,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 15, 2024
Nanohydrogel
wound
healing
refers
to
the
use
of
nanotechnology-based
hydrogel
materials
promote
wounds.
Hydrogel
dressings
are
made
up
a
three-dimensional
network
hydrophilic
polymers
that
can
absorb
and
retain
large
amounts
water
or
other
fluids.
Nanohydrogels
take
this
concept
further
by
incorporating
nanoscale
particles
structures
into
matrix.
These
nanoparticles
be
various
materials,
such
as
silver,
zinc
oxide,
derived
from
natural
substances
like
chitosan.
The
inclusion
provide
additional
properties
benefits
dressings.
designed
release
bioactive
substances,
growth
factors
drugs,
in
controlled
manner.
This
allows
for
targeted
delivery
therapeutics
site,
promoting
reducing
inflammation.
Nanoparticles
reinforce
structure
hydrogels,
improving
their
mechanical
strength
stability.
often
incorporate
antimicrobial
nanoparticles,
silver
oxide.
have
shown
effective
activity
against
wide
range
bacteria,
fungi,
pathogens.
By
them
dressings,
nanohydrogels
help
prevent
reduce
risk
infection
encapsulate
factors,
peptides,
sustained
therapeutic
agents
promotes
facilitating
cell
proliferation,
inflammation,
supporting
tissue
regeneration.
unique
nanohydrogels,
including
ability
maintain
moist
environment
deliver
agents,
accelerate
process.
creating
an
optimal
repair,
faster
more
efficient
Pharmaceuticals,
Год журнала:
2024,
Номер
17(7), С. 897 - 897
Опубликована: Июль 5, 2024
Wound
healing
can
result
in
complex
problems,
and
discovering
an
effective
method
to
improve
the
process
is
essential.
Polymeric
biomaterials
have
structures
similar
those
identified
extracellular
matrix
of
tissue
be
regenerated
also
avoid
chronic
inflammation,
immunological
reactions.
To
obtain
smart
dressings,
bioactive
agents,
such
as
essential
oils,
are
used
promote
a
wide
range
biological
properties,
which
accelerate
process.
Therefore,
we
intend
explore
advances
potential
for
applying
hybrid
materials
wound
healing.
For
this,
fifty
scientific
articles
dated
from
2010
2023
were
investigated
using
Web
Science,
Scopus,
Science
Direct,
PubMed
databases.
The
principles
process,
use
polymers,
type
properties
oils
processing
techniques,
characteristics
dressings
identified.
Thus,
plants
Syzygium
romanticum
or
Eugenia
caryophyllata,
Origanum
vulgare,
Cinnamomum
zeylanicum
present
prospects
application
clinical
trials
due
their
proven
effects
on
reducing
incidence
inflammatory
cells
site
injury.
antimicrobial
effect
mainly
polyphenols
terpenes
eugenol,
cinnamaldehyde,
carvacrol,
thymol.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(5), С. 6315 - 6326
Опубликована: Янв. 26, 2024
The
development
of
cell-like
nanoreactors
with
the
ability
to
initiate
biocatalytic
cascades
under
special
conditions
holds
tremendous
potential
for
therapeutic
applications.
Herein,
conformationally
gated
that
respond
acidic
microenvironment
infected
diabetic
wounds
were
developed
by
cucur[8]bituril
(CB[8])-based
supramolecular
assembly.
bioinspired
exhibit
not
only
self-regulated
permeability
and
selectivity
control
internal
enzyme
activities
substance
exchange
but
also
distinct
binding
specificities
toward
Gram-positive
Gram-negative
bacteria
via
noncovalent
modification
different
ligands.
encapsulation
glucose
oxidase
(GOx),
Fe3O4
nanozyme,
l-arginine
(l-Arg)
into
nanocarriers
enables
intelligent
activation
multienzyme
cascade
reactions
upon
(Glu)
uptake
produce
gluconic
acid
(GA)
hydrogen
peroxide
(H2O2),
which
is
further
converted
highly
toxic
hydroxyl
radicals
(·OH)
selective
antibacterial
activity.
Moreover,
H2O2
promotes
oxidization
l-Arg,
leading
release
nitric
oxide
(NO).
Consequently,
this
nanoreactor
provides
a
multifunctional
synergistic
platform
chronic
wound
healing
combining
dynamic
therapy
NO
gas
combat
bacterial
infections
inflammation
high
blood
Glu
levels.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Abstract
Hypoxia,
inflammatory
response
and
pathogen
(bacterial
or
viral)
infection
are
the
three
main
factors
that
lead
to
death
in
patients
with
acute
lung
injury
(ALI).
Among
them,
hypoxia
activates
expression
of
HIF‐1α,
further
exacerbating
production
ROS
response.
Currently,
anti‐inflammatory
elimination
treatment
strategies
have
effectively
alleviated
infectious
pneumonia,
but
improving
still
faces
challenges.
Here,
a
vancomycin‐loaded
nanoventilator
(SCVN)
containing
superoxide
dismutase
(SOD)
catalase
(CAT)
is
developed,
which
prepared
by
encapsulating
SOD,
CAT
vancomycin
into
nanocapsule
situ
polymerization.
This
can
improve
stability
loading
rate
enzymes,
enhance
their
enzyme
cascade
efficiency,
thereby
efficiently
consuming
•O
2
−
H
O
generate
reducing
level.
More
interestingly,
supply
relieve
reduce
HIF‐1α
balance
number
M1/M2
macrophages
levels
TNF‐α,
IL‐1β
IL‐6,
alleviating
Meanwhile,
target
kill
MRSA,
fundamentally
solving
cause
pneumonia.
antibacterial,
anti‐inflammatory,
scavenging
functions
will
provide
universal
clinical
strategy
for
ALI
caused
pathogens.
European Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
unknown, С. 107132 - 107132
Опубликована: Май 1, 2025
Three-dimensional
(3D)
printed
hydrogel-based
scaffolds
have
emerged
as
promising
for
the
delivery
of
biologicals.
Recently,
we
developed
a
printable
plant-based
nanocomposite
hydrogel,
composed
anionic
cellulose
nanofibers
(T-CNF)
and
methacrylated
galactoglucomannan
(GGMMA),
reinforced
with
mesoporous
silica
nanoparticles
(MSNs)
different
surface
charges.
However,
ensuring
biological
activity
delivered
biomolecules
requires
further
investigation
to
validate
functionality
biomaterial.
To
investigate
this,
in
this
study,
horseradish
peroxidase
(HRP)
lysozyme
were
selected
distinct
model
proteins,
assessing
their
immobilization
stability
after
MSN
3D
printing.
The
interactions
between
enzymes
differently
surface-modified
MSNs
explored
using
multi-parametric
plasmon
resonance
(MP-SPR)
molecular
dynamics
(MD)
simulations.
We
observed
that
charge
is
key
extent
enzyme
adsorption
control.
Positively
charged
showed
highest
HRP
but
caused
significant
loss
both
enzymes.
In
contrast,
near-neutral
negatively
provided
improved
retention
lysozyme,
respectively.
Except
lysozyme/hydrogel,
HRP/hydrogel
enzyme-loaded
hydrogels
(HRP-loaded
lysozyme-loaded
MSNs)
successfully
UV
post-curing
times.
While
enzyme-laden
stability,
presence
photoinitiator
inactivation
Irrespective
crosslinking
approach,
matrix
demonstrates
potential
carrier
various
biomolecules,
applications
tissue
engineering
wound
healing.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 15, 2025
Diabetic
wound
healing
presents
a
significant
medical
challenge
and
requires
multistep
interventions
due
to
comprehensive
environments,
such
as
hyperglycemia,
bacterial
infection,
impaired
angiogenesis.
However,
current
are
complicated
need
on-demand
sequential
release
synergy
of
multicomponents.
Herein,
H2S-releasing
cascade
nanozyme
(FeS@Au),
which
is
composed
ultrasmall
gold
nanocluster
(AuNC)
loaded
on
ferrous
sulfide
nanoparticle
(FeSNP),
developed
single
component
regulate
glucose
level,
eliminate
promote
angiogenesis,
achieving
for
diabetic
treatment.
The
oxidase-like
activity
AuNC
catalyzes
into
gluconic
acid
H2O2,
not
only
lowers
the
local
level
but
also
decreases
pH
increases
H2O2
boost
peroxidase-like
FeSNP
generate
abundant
hydroxyl
radical
(reactive
oxygen
species,
ROS),
inducing
ferroptosis-like
death
in
drug-resistant
bacteria.
Additionally,
H2S
acidified
environment
upregulate
hypoxia-inducible
factor-1
enhance
vascularization
through
upregulating
expression
vascular
endothelial
growth
factor
(VEGF)
other
angiogenesis-related
genes,
reducing
damage
cells
caused
by
excessive
ROS
produced
nanozyme.
In
full-thickness
MRSA-infected
rat
model,
FeS@Au
significantly
eliminates
bacteria,
enhances
promotes
collagen
deposition,
accelerates
healing.
This
work
with
H2S-release
interventions,
providing
versatile
strategy
extensive
tissue
diabetes.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Май 23, 2023
Introduction:
Diabetic
oral
mucosa
ulcers
face
challenges
of
hypoxia,
hyperglycemia
and
high
oxidative
stress,
which
result
in
delayed
healing
process.
Oxygen
is
regarded
as
an
important
substance
cell
proliferation,
differentiation
migration,
beneficial
to
ulcer
recovery.
Methods:
This
study
developed
a
multi-functional
GOx-CAT
nanogel
(GCN)
system
for
the
treatment
diabetic
ulcers.
The
catalytic
activity,
ROS
scavenge
oxygen
supply
ability
GCN
was
validated.
therapeutic
effect
verified
gingival
model.
Results:
results
showed
that
nanoscale
capable
significantly
eliminating
intracellular
ROS,
increasing
concentration
accelerating
migration
human
fibroblasts,
could
promote
vivo
by
alleviating
inflammation
promoting
angiogenesis.
Discussion:
multifunctional
with
depletion,
continuous
good
biocompatibility,
might
provide
novel
strategy
effective
