ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(45), P. 44860 - 44875
Published: Nov. 1, 2024
A
diabetic
wound
exemplifies
the
challenge
of
chronic,
nonhealing
wounds.
Elevated
blood
sugar
levels
in
diabetes
profoundly
disrupt
macrophage
function,
impairing
crucial
activities
such
as
phagocytosis,
immune
response,
cell
migration,
and
vessel
formation,
all
essential
for
effective
healing.
Moreover,
persistent
presence
pro-inflammatory
cytokines
reactive
oxygen
species,
coupled
with
a
decrease
anti-inflammatory
factors,
exacerbates
delay
healing
associated
diabetes.
This
review
emphasizes
dysfunctional
inflammatory
responses
underlying
wounds
explores
preclinical
studies
inflammation-modulating
bioactives
biomaterials
that
show
promise
expediting
Additionally,
this
provides
an
overview
selected
clinical
employing
bioactive
molecules,
shedding
light
on
gap
between
extensive
research
limited
field.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(7), P. 897 - 897
Published: July 5, 2024
Wound
healing
can
result
in
complex
problems,
and
discovering
an
effective
method
to
improve
the
process
is
essential.
Polymeric
biomaterials
have
structures
similar
those
identified
extracellular
matrix
of
tissue
be
regenerated
also
avoid
chronic
inflammation,
immunological
reactions.
To
obtain
smart
dressings,
bioactive
agents,
such
as
essential
oils,
are
used
promote
a
wide
range
biological
properties,
which
accelerate
process.
Therefore,
we
intend
explore
advances
potential
for
applying
hybrid
materials
wound
healing.
For
this,
fifty
scientific
articles
dated
from
2010
2023
were
investigated
using
Web
Science,
Scopus,
Science
Direct,
PubMed
databases.
The
principles
process,
use
polymers,
type
properties
oils
processing
techniques,
characteristics
dressings
identified.
Thus,
plants
Syzygium
romanticum
or
Eugenia
caryophyllata,
Origanum
vulgare,
Cinnamomum
zeylanicum
present
prospects
application
clinical
trials
due
their
proven
effects
on
reducing
incidence
inflammatory
cells
site
injury.
antimicrobial
effect
mainly
polyphenols
terpenes
eugenol,
cinnamaldehyde,
carvacrol,
thymol.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Abstract
Diabetic
wound
healing
presents
a
persistent
clinical
challenge,
often
characterized
by
prolonged
times,
and
can
be
particularly
difficult
to
achieve
in
hyperglycemic
environment.
In
this
study,
multi‐functional
silver‐enzyme
nanogels
assembly
(Ag‐nGHC)
is
designed
focusing
on
the
complex
diabetic
Glucose
oxidase
(GOX),
horseradish
peroxidase
(HRP),
catalase
(CAT)
are
modified
within
polymeric
nanogel
layers
assembled
into
large
enzyme
cluster
with
silver
ions.
The
close
attachment
of
three
enzymes
ensures
fast
continuous
consumption
high
level
glucose,
generation
oxygen,
hydroxyl
radicals
(•OH)
around
site.
Meanwhile,
ions
Ag‐nGHC
act
as
an
effective
agent
kill
bacteria.
This
cascade
system
significantly
improves
microenvironment
site
reducing
bacterium
infection
alleviating
hypoxia
well
hyperglycemia.
Sequentially,
improved
environment
facilitates
later
processes
including
anti‐inflammatory,
re‐epithelialization,
angiogenesis,
evidenced
enhancing
polarization
toward
M2
macrophages
increasing
CD31
signals
study.
Overall,
materials
proven
multifunctional
properties
complicated
(attributes
such
adaptability,
hypoxia‐alleviated,
anti‐hyperglycemic,
antimicrobial,
angiogenic)
showed
great
potential
for
treatment
chronic
wound.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(5), P. 6315 - 6326
Published: Jan. 26, 2024
The
development
of
cell-like
nanoreactors
with
the
ability
to
initiate
biocatalytic
cascades
under
special
conditions
holds
tremendous
potential
for
therapeutic
applications.
Herein,
conformationally
gated
that
respond
acidic
microenvironment
infected
diabetic
wounds
were
developed
by
cucur[8]bituril
(CB[8])-based
supramolecular
assembly.
bioinspired
exhibit
not
only
self-regulated
permeability
and
selectivity
control
internal
enzyme
activities
substance
exchange
but
also
distinct
binding
specificities
toward
Gram-positive
Gram-negative
bacteria
via
noncovalent
modification
different
ligands.
encapsulation
glucose
oxidase
(GOx),
Fe3O4
nanozyme,
l-arginine
(l-Arg)
into
nanocarriers
enables
intelligent
activation
multienzyme
cascade
reactions
upon
(Glu)
uptake
produce
gluconic
acid
(GA)
hydrogen
peroxide
(H2O2),
which
is
further
converted
highly
toxic
hydroxyl
radicals
(·OH)
selective
antibacterial
activity.
Moreover,
H2O2
promotes
oxidization
l-Arg,
leading
release
nitric
oxide
(NO).
Consequently,
this
nanoreactor
provides
a
multifunctional
synergistic
platform
chronic
wound
healing
combining
dynamic
therapy
NO
gas
combat
bacterial
infections
inflammation
high
blood
Glu
levels.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Abstract
Hypoxia,
inflammatory
response
and
pathogen
(bacterial
or
viral)
infection
are
the
three
main
factors
that
lead
to
death
in
patients
with
acute
lung
injury
(ALI).
Among
them,
hypoxia
activates
expression
of
HIF‐1α,
further
exacerbating
production
ROS
response.
Currently,
anti‐inflammatory
elimination
treatment
strategies
have
effectively
alleviated
infectious
pneumonia,
but
improving
still
faces
challenges.
Here,
a
vancomycin‐loaded
nanoventilator
(SCVN)
containing
superoxide
dismutase
(SOD)
catalase
(CAT)
is
developed,
which
prepared
by
encapsulating
SOD,
CAT
vancomycin
into
nanocapsule
situ
polymerization.
This
can
improve
stability
loading
rate
enzymes,
enhance
their
enzyme
cascade
efficiency,
thereby
efficiently
consuming
•O
2
−
H
O
generate
reducing
level.
More
interestingly,
supply
relieve
reduce
HIF‐1α
balance
number
M1/M2
macrophages
levels
TNF‐α,
IL‐1β
IL‐6,
alleviating
Meanwhile,
target
kill
MRSA,
fundamentally
solving
cause
pneumonia.
antibacterial,
anti‐inflammatory,
scavenging
functions
will
provide
universal
clinical
strategy
for
ALI
caused
pathogens.
Diabetic
wound
healing
presents
a
significant
medical
challenge
and
requires
multistep
interventions
due
to
comprehensive
environments,
such
as
hyperglycemia,
bacterial
infection,
impaired
angiogenesis.
However,
current
are
complicated
need
on-demand
sequential
release
synergy
of
multicomponents.
Herein,
H2S-releasing
cascade
nanozyme
(FeS@Au),
which
is
composed
ultrasmall
gold
nanocluster
(AuNC)
loaded
on
ferrous
sulfide
nanoparticle
(FeSNP),
developed
single
component
regulate
glucose
level,
eliminate
promote
angiogenesis,
achieving
for
diabetic
treatment.
The
oxidase-like
activity
AuNC
catalyzes
into
gluconic
acid
H2O2,
not
only
lowers
the
local
level
but
also
decreases
pH
increases
H2O2
boost
peroxidase-like
FeSNP
generate
abundant
hydroxyl
radical
(reactive
oxygen
species,
ROS),
inducing
ferroptosis-like
death
in
drug-resistant
bacteria.
Additionally,
H2S
acidified
environment
upregulate
hypoxia-inducible
factor-1
enhance
vascularization
through
upregulating
expression
vascular
endothelial
growth
factor
(VEGF)
other
angiogenesis-related
genes,
reducing
damage
cells
caused
by
excessive
ROS
produced
nanozyme.
In
full-thickness
MRSA-infected
rat
model,
FeS@Au
significantly
eliminates
bacteria,
enhances
promotes
collagen
deposition,
accelerates
healing.
This
work
with
H2S-release
interventions,
providing
versatile
strategy
extensive
tissue
diabetes.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: May 23, 2023
Introduction:
Diabetic
oral
mucosa
ulcers
face
challenges
of
hypoxia,
hyperglycemia
and
high
oxidative
stress,
which
result
in
delayed
healing
process.
Oxygen
is
regarded
as
an
important
substance
cell
proliferation,
differentiation
migration,
beneficial
to
ulcer
recovery.
Methods:
This
study
developed
a
multi-functional
GOx-CAT
nanogel
(GCN)
system
for
the
treatment
diabetic
ulcers.
The
catalytic
activity,
ROS
scavenge
oxygen
supply
ability
GCN
was
validated.
therapeutic
effect
verified
gingival
model.
Results:
results
showed
that
nanoscale
capable
significantly
eliminating
intracellular
ROS,
increasing
concentration
accelerating
migration
human
fibroblasts,
could
promote
vivo
by
alleviating
inflammation
promoting
angiogenesis.
Discussion:
multifunctional
with
depletion,
continuous
good
biocompatibility,
might
provide
novel
strategy
effective
