Photochromism into nanosystems: towards lighting up the future nanoworld

Chemical Society Reviews, Год журнала: 2017, Номер 47(3), С. 1044 - 1097

Опубликована: Дек. 18, 2017

This review provides a state-of-the-art account of photochromism into diverse functional nanosystems such as nanomachines, nanoparticles, nanoelectronics, nanoassemblies and biological nanosystems.

Язык: Английский

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Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Chemical Reviews, Год журнала: 2020, Номер 120(24), С. 13135 - 13272

Опубликована: Окт. 30, 2020

Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species interest. Recent years have seen development PPGs activatable by biologically and chemically benign visible near-infrared (NIR) light. These long-wavelength-absorbing moieties expand applicability this powerful method its accessibility non-specialist users. This review comprehensively covers organic transition metal-containing photoactivatable compounds (complexes) that absorb in visible- NIR-range various leaving gasotransmitters (carbon monoxide, nitric oxide, hydrogen sulfide). The text NIR-light-induced photosensitized using molecular sensitizers, quantum dots, upconversion second-harmonic nanoparticles, well via photodynamic (photooxygenation singlet oxygen) photothermal effects. Release from polymers, micelles, vesicles, photoswitches, along with related emerging field photopharmacology, is discussed at end review.

Язык: Английский

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PROTACs: An Emerging Therapeutic Modality in Precision Medicine

Cell chemical biology, Год журнала: 2020, Номер 27(8), С. 998 - 1014

Опубликована: Авг. 1, 2020

Язык: Английский

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A NIR Light Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of MicroRNA in Cells and Animals

Journal of the American Chemical Society, Год журнала: 2019, Номер 141(17), С. 7056 - 7062

Опубликована: Март 31, 2019

Nanodevices have potential as intelligent sensing systems for detection of microRNAs (miRNAs) in living cells. However, the resolution offered by "always active" nanodevices is often insufficient to manipulate miRNA with high spatiotemporal control. In this work, using DNA nanotechnology we constructed an activatable nanodevice programmed detect miRNAs vitro and vivo spatial temporal precision NIR light. Our functionalized on surface upconversion nanoparticles (UCNPs) a rationally designed beacon that displays UV light-activatable activity. The UCNPs absorb deep-tissue-penetrable light emit high-energy locally, which serve transducers operate window. can naturally enter cells enable remote regulation its fluorescent imaging activity illumination chosen place time. Furthermore, demonstrate be expanded intratumoral mice. This work illustrates resolution, could expand toolbox technologies precise biological medical analysis.

Язык: Английский

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Nanoarchitectonics beyond Self‐Assembly: Challenges to Create Bio‐Like Hierarchic Organization

Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(36), С. 15424 - 15446

Опубликована: Март 14, 2020

Abstract Incorporation of non‐equilibrium actions in the sequence self‐assembly processes would be an effective means to establish bio‐like high functionality hierarchical assemblies. As a novel methodology beyond self‐assembly, nanoarchitectonics, which has as its aim fabrication functional materials systems from nanoscopic units through methodological fusion nanotechnology with other scientific disciplines including organic synthesis, supramolecular chemistry, microfabrication, and bio‐process, been applied this strategy. The application factors conventional is discussed on basis examples directed assembly, Langmuir–Blodgett layer‐by‐layer assembly. In particular, structures using bio‐active components such proteins or by combination bio‐components two‐dimensional nanomaterials, are described. Methodologies described review article highlight possible approaches nanoarchitectonics concept for creation higher functionalities structural organization.

Язык: Английский

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Optical Control of Small Molecule-Induced Protein Degradation

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(5), С. 2193 - 2197

Опубликована: Янв. 13, 2020

As an emerging approach to protein perturbation, small molecule-induced degradation has gained significant attention as both a chemical tool and potential therapeutic. To enable discrete control over its function, we have developed broadly applicable for the optical activation of degradation. By installing two different photolabile protecting groups, so-called caging onto ligands recruiting Von Hippel–Lindau (VHL) cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-triggered any molecule warhead.

Язык: Английский

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Water-Soluble BODIPY Photocages with Tunable Cellular Localization

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(11), С. 4970 - 4974

Опубликована: Фев. 29, 2020

Photoactivation of bioactive molecules allows manipulation cellular processes with high spatiotemporal precision. The recent emergence visible-light excitable photoprotecting groups has the potential to further expand established utility photoactivation strategy in biological applications by offering higher tissue penetration, diminished phototoxicity, and compatibility other light-dependent techniques. Nevertheless, a critical barrier such remains significant hydrophobicity most photocaging groups. Here, we find that applying conventional 2,6-sulfonation meso-methyl BODIPY photocages is incompatible their photoreaction due an increase excited state for photorelease. We present simple, remote sulfonation solution imparts water solubility provides control over permeability while retaining favorable spectroscopic properties. Peripherally disulfonated are cell impermeable, making them useful modulation cell-surface receptors, monosulfonated retains ability cross membrane can modulate intracellular targets. This new approach generalizable controlling localization was validated sensitization mammalian cells neurons signaling molecules.

Язык: Английский

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Taking phototherapeutics from concept to clinical launch

Nature Reviews Chemistry, Год журнала: 2021, Номер 5(11), С. 816 - 834

Опубликована: Окт. 6, 2021

Язык: Английский

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Clip Chemistry: Diverse (Bio)(macro)molecular and Material Function through Breaking Covalent Bonds

Chemical Reviews, Год журнала: 2021, Номер 121(12), С. 7059 - 7121

Опубликована: Апрель 6, 2021

In the two decades since introduction of "click chemistry" concept, toolbox reactions" has continually expanded, enabling chemists, materials scientists, and biologists to rapidly selectively build complexity for their applications interest. Similarly, selective efficient covalent bond breaking reactions have provided will continue provide transformative advances. Here, we review key examples efficient, cleavage reactions, which refer herein as "clip reactions." The strategic application clip offers opportunities tailor compositions structures complex (bio)(macro)molecular systems with exquisite control. Working in concert, click chemistry offer scientists engineers powerful methods address next-generation challenges across chemical sciences.

Язык: Английский

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Stepping Out of the Blue: From Visible to Near‐IR Triggered Photoswitches

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(31)

Опубликована: Май 7, 2022

Abstract Light offers unique opportunities for controlling the activity of materials and biosystems with high spatiotemporal resolution. Molecular photoswitches are chromophores that undergo reversible isomerization between different states upon irradiation light, allowing a convenient means to control their influence over system interest. However, significant limitation classical is requirement initiate switching in one or both directions using deleterious UV light poor tissue penetration. Red‐shifted hence demand have attracted keen recent research In this Review, we highlight progress towards development visible‐ NIR‐activated characterized by distinct photochromic reaction mechanisms. We hope inspire further endeavors field, full potential these tools biotechnology chemistry applications be realized.

Язык: Английский

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