Bioresponsive fluorescent probes active in the second near‐infrared window DOI Creative Commons
Yuqin Chen, Jie Chen, Baisong Chang

и другие.

iRadiology, Год журнала: 2023, Номер 1(1), С. 36 - 60

Опубликована: Март 1, 2023

Abstract Emerging stimuli‐responsive composite probes active in the second near‐infrared window (NIR‐II, 1000–1700 nm) hold vast potential for improving vivo imaging performance with minimized noise interference. The interactions among external irradiation, shell species, and emissive core are key factors design of smart structures. irradiation provides energy species to generate intense NIR‐II fluorescence signals, while transfer process hinders emission inner structure probes. However, if pathophysiological stimuli interrupt above processes, then signals recovered. This review covers based on diverse fluorescent responding various biological stimuli, including ONOO − , overexpressed reactive sulfur abnormally expressed enzymes, abnormal levels physiological metabolites. Finally, appreciate these advances, challenges perspectives highlighted.

Язык: Английский

An Activatable Phototheranostic Probe for Anti‐hypoxic Type I Photodynamic‐ and Immuno‐Therapy of Cancer DOI Open Access
Min Zhao, Yuyang Zhang,

Jia Miao

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(4)

Опубликована: Авг. 29, 2023

Photodynamic therapy (PDT), which utilizes type I photoreactions, has great potential as an effective cancer treatment because of its hypoxia-tolerant superiority over the commonly used II pathway. A few photosensitizers are exploited; however, they majorly induce cytotoxicity and possess poor tumor specificity low-efficient theranostics. To resolve this issue, herein aminopeptidase N (APN)-activated phototheranostic probe (CyA) is reported for anti-hypoxic PDT in conjunction with immunotherapy treatment. CyA can specifically activate near-infrared fluorescence, photoacoustic signals, phototoxicity following APN-induced substrate cleavage subsequent generation active molecules (such CyBr). endows specific imaging capabilities toward cells overexpressing APN under both normoxia hypoxia. In addition, locally activatable induces systemic antitumor immune responses. More importantly, integration localized activated evokes enhanced therapeutic effects improved inhibition efficiency live mice compared individual treatments. This study aims to present combination therapy.

Язык: Английский

Процитировано

65
Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications DOI Creative Commons
Lawrence Cho‐Cheung Lee, Kenneth Kam‐Wing Lo

Chemical Reviews, Год журнала: 2024, Номер 124(15), С. 8825 - 9014

Опубликована: Июль 25, 2024

Luminescence imaging is a powerful and versatile technique for investigating cell physiology pathology in living systems, making significant contributions to life science research clinical diagnosis. In recent years, luminescent transition metal complexes have gained attention diagnostic therapeutic applications due their unique photophysical photochemical properties. this Review, we provide comprehensive overview of the development bioimaging biosensing applications, with focus on centers d

Язык: Английский

Процитировано

52
Nanoprobe-based molecular imaging for tumor stratification DOI

Xianbin Ma,

Mingchuan Mao,

Jiaqi He

и другие.

Chemical Society Reviews, Год журнала: 2023, Номер 52(18), С. 6447 - 6496

Опубликована: Янв. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Язык: Английский

Процитировано

51
Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium(II) Metallacycle DOI
Le Tu,

Chonglu Li,

Qihang Ding

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(13), С. 8991 - 9003

Опубликована: Март 21, 2024

Though immunogenic cell death (ICD) has garnered significant attention in the realm of anticancer therapies, effectively stimulating strong immune responses with minimal side effects deep-seated tumors remains challenging. Herein, we introduce a novel self-assembled near-infrared-light-activated ruthenium(II) metallacycle, Ru1105 (λem = 1105 nm), as first example Ru(II) supramolecular ICD inducer. synergistically potentiates immunomodulatory and reduces adverse through multiple regulated approaches, including NIR-light excitation, increased reactive oxygen species (ROS) generation, selective targeting tumor cells, precision organelle localization, improved penetration/retention capabilities. Specifically, demonstrates excellent depth-activated ROS production (∼1 cm), resistance to diffusion, anti-ROS quenching. Moreover, exhibits promising results cellular uptake generation cancer cells multicellular spheroids. Importantly, induces more efficient an ultralow dose (10 μM) compared conventional agent, oxaliplatin (300 μM). In vivo experiments further confirm Ru1105's potency inducer, eliciting CD8+ T depleting Foxp3+ effects. Our research lays foundation for design secure exceptionally potent metal-based agents immunotherapy.

Язык: Английский

Процитировано

48
Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes DOI
Wei Pan, Muhammad Rafiq,

Waqas Haider

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 514, С. 215907 - 215907

Опубликована: Май 12, 2024

Язык: Английский

Процитировано

33
Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries DOI
Yang Shen, Wei Li, Zhixuan Zhou

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(32)

Опубликована: Май 23, 2024

Clear delineation of tumor margins is essential for accurate resection and decreased recurrence rate in the clinic. Fluorescence imaging emerging as a promising alternative to traditional visual inspection by surgeons intraoperative imaging. However, probes lack accuracy diagnosis, making it difficult depict boundaries accurately. Herein, we proposed an offensive defensive integration (ODI) strategy based on "attack systems (invasive peptidase) defense (reductive microenvironment)" multi-dimensional characteristics design activatable fluorescent precisely. Screened out from series ODI strategy-based probes, ANQ performed better than unilateral correlation distinguishing between cells normal minimizing false-positive signals living metabolic organs. To further improve signal-to-background ratio vivo, derivatized FANQ, was prepared successfully applied distinguish orthotopic hepatocellular carcinoma tissues adjacent mice models clinical samples. This work highlights innovative develop rapid diagnosis tumors high-precision boundaries, providing more efficient tools future applications assisted resection.

Язык: Английский

Процитировано

22
Advances in small-molecule fluorescent probes for the study of apoptosis DOI

Ya‐Xi Ye,

Jian-Cheng Pan, Haichao Wang

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(18), С. 9133 - 9189

Опубликована: Янв. 1, 2024

Small-molecule fluorescent probes for studying apoptosis.

Язык: Английский

Процитировано

20
Tandem-controlled lysosomal assembly of nanofibres induces pyroptosis for cancer immunotherapy DOI

Junya Zhang,

Yuxuan Hu,

Xidan Wen

и другие.

Nature Nanotechnology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

3
A Tumor‐Microenvironment‐Activatable Molecular Pro‐Theranostic Agent for Photodynamic and Immunotherapy of Cancer DOI
Hui Zhou, Yuan Zhang, Ruru Zhang

и другие.

Advanced Materials, Год журнала: 2023, Номер 35(30)

Опубликована: Апрель 22, 2023

Cancer-associated fibroblasts (CAFs) are the major components of tumor-associated matrix and play an important role in tumor progression immunosuppression. Therefore, precise theranostics CAFs beneficial for CAFs-targeted therapies. However, imaging agents enabling have been rarely exploited. To tackle this issue, a molecular pro-theranostic probe (FMP) with activatable fluorescence, photoacoustic (PA) imaging, photodynamic therapy (PDT) is developed response to fibroblast activation protein α (FAPα) overexpressed >90% types some cells. Attributed efficient phototoxicity toward cells, together activated immunogenic cell death (ICD), complete regression primary tumors abscopal effect distant observed 4T1-tumor-bearing mice model. By integration PD-L1 checkpoint blockade immunotherapy, enhanced systemic immune responses evoked obtain long-lasting suppression both as well arrest cancer metastasis living mice.

Язык: Английский

Процитировано

39
A DNA Logic Circuit Equipped with a Biological Amplifier Loaded into Biomimetic ZIF‐8 Nanoparticles Enables Accurate Identification of Specific Cancers In Vivo DOI
Kaiji Wei,

Mengyun He,

Juan Zhang

и другие.

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(41)

Опубликована: Авг. 24, 2023

DNA logic circuits (DLC) enable the accurate identification of specific cell types, such as cancer cells, but they face challenges weak output signals and a lack competent platforms that can efficiently deliver DLC components to target site in living body. To address these issues, we rationally introduced cascaded biological amplifier module based on Primer Exchange Reaction inspired by electronic circuit devices. As paradigm, three abnormally expressed Hela microRNAs (-30a, -17, -21) were chosen "AND" gate inputs. response inputs was boosted markedly enhancing signal. More importantly, encapsulation into ZIF-8 nanoparticles resulted their efficient delivery site, successfully distinguishing tumor subtype from other tumors vivo. Thus, envision this strategy has great potential for clinical diagnosis.

Язык: Английский

Процитировано

32