Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(14)
Опубликована: Янв. 18, 2023
Abstract
Near‐infrared
(NIR)
fluorophores
with
characteristics
such
as
deep
tissue
penetration,
minimal
damage
to
the
biological
samples,
and
low
background
interference,
are
highly
sought‐after
materials
for
in
vivo
deep‐tissue
fluorescence
imaging.
Herein,
series
of
3‐pyrrolylBODIPY
derivatives
3,5‐dipyrrolylBODIPY
have
been
prepared
by
a
facile
regioselective
nucleophilic
aromatic
substitution
reaction
(S
N
Ar)
on
3,5‐halogenated
BODIPY
(3,5‐dibromo
or
2,3,5,6‐tetrachloroBODIPYs)
pyrroles.
The
installation
pyrrolic
unit
onto
3‐position
chromophore
leads
dramatic
red
shift
both
absorption
(up
160
nm)
emission
260
these
resultant
3‐pyrrolylBODIPYs
respect
that
chromophore.
Their
further
5‐positional
functionalization
provides
way
fine
tune
their
photophysical
properties,
resulting
dipyrrolylBODIPYs
functionalized
pyrrolylBODIPYs
show
strong
red‐to‐NIR
regions
(595–684
intense
NIR
(650–715
dichloromethane.
To
demonstrate
applicability
fluorescent
probes
cell
imaging,
pyrrolylBODIPY
6
containing
mitochondrion‐targeting
butyltriphenylphosphonium
cationic
species
was
also
prepared.
It
selectively
localized
mitochondria
HeLa
cells,
cytotoxicity
emission.
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 6891 - 6952
Опубликована: Май 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Advanced Materials,
Год журнала:
2023,
Номер
36(1)
Опубликована: Авг. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Advanced Materials,
Год журнала:
2023,
Номер
35(35)
Опубликована: Апрель 20, 2023
Photothermal
therapy
(PTT)
has
received
increasing
interest
in
cancer
therapeutics
owing
to
its
excellent
efficacy
and
controllability.
However,
there
are
two
major
limitations
PTT
applications,
which
the
tissue
penetration
depth
of
lasers
within
absorption
range
photothermal
agents
unavoidable
empyrosis
induced
by
high-energy
lasers.
Herein,
a
gas/phototheranostic
nanocomposite
(NA1020-NO@PLX)
is
engineered
that
integrates
second
near-infrared-peak
(NIR-II-peak)
absorbing
aza-boron-dipyrromethenes
(aza-BODIPY,NA1020)
with
thermal-sensitive
nitric
oxide
(NO)
donor
(S-nitroso-N-acetylpenicillamine,
SNAP).
An
enhanced
intramolecular
charge
transfer
mechanism
proposed
achieve
NIR-II-peak
absorbance
(λmax
=
1020
nm)
on
NA1020,
thereby
obtaining
deep
depth.
The
NA1020
exhibits
remarkable
conversion,
making
it
feasible
for
deep-tissue
orthotopic
osteosarcoma
providing
favorable
NIR-II
emission
precisely
pinpoint
tumor
visible
process.
simultaneously
investigated
atraumatic
therapeutic
process
an
cell
apoptosis
indicates
feasibility
synergistic
NO/low-temperature
osteosarcoma.
this
strategy
optimizes
existing
present
repeatable
tumors,
validating
potential
clinical
applications.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(11)
Опубликована: Янв. 16, 2024
Abstract
Achieving
photothermal
therapy
(PTT)
at
ultralow
laser
power
density
is
crucial
for
minimizing
photo‐damage
and
allowing
higher
maximum
permissible
skin
exposure.
However,
this
requires
agents
to
possess
not
just
superior
conversion
efficiency
(PCE),
but
also
exceptional
near‐infrared
(NIR)
absorptivity.
J
‐aggregates,
exhibit
a
significant
redshift
narrower
absorption
peak
with
extinction
coefficient.
Nevertheless,
achieving
predictable
‐aggregates
through
molecular
design
remains
challenge.
In
study,
we
successfully
induced
desirable
J‐
aggregation
(λ
abs
max
:
968
nm,
ϵ:
2.96×10
5
M
−1
cm
,
λ
em
972
Φ
FL
6.2
%)
by
tuning
electrostatic
interactions
between
π‐conjugated
planes
manipulating
surface
potential
of
aromatic
ring‐fused
aza‐BODIPY
dyes.
Notably,
controlling
the
preparation
method
encapsulating
dyes
into
F‐127
polymer,
were
able
selectively
generate
H
‐/
respectively.
Furthermore,
exhibited
two
controllable
morphologies:
nanospheres
nanowires.
Importantly,
shortwave‐infrared
‐aggregated
nanoparticles
impressive
PCE
72.9
%
effectively
destroyed
cancer
cells
mice‐tumors
an
0.27
W
−2
(915
nm).
This
phototherapeutic
nano‐platform,
which
generates
behavior,
can
controllably
form
/
H‐
aggregates
selectable
aggregate
morphology,
valuable
paradigm
developing
tumor‐treatment
density.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Март 29, 2024
Abstract
Fluorescence
imaging
in
the
second
near‐infrared
window
(NIR‐II,
1000–1700
nm)
has
aroused
immense
attention
for
biomedical
applications,
offering
exceptional
advantages
such
as
ultra‐low
photon
scattering
and
increased
tissue
penetration.
Among
NIR‐II‐emitted
organic
dyes,
Boron
dipyrromethene
(BODIPY),
emerged
a
noteworthy
candidate.
BODIPY,
distinguished
by
its
controllable
molecular
structure
optical
properties,
outstanding
fluorescence
quantum
yields,
high
molar
absorption
coefficients,
remarkable
chemical
stability,
undergone
comprehensive
investigation
extensive
exploration
within
realm
of
biological
theranostics.
This
work
aims
to
provide
summary
advancements
development
design
strategies
NIR‐II
BODIPY
fluorophores
tailored
advanced
phototheranostics.
Initially,
elucidates
several
representative
strategies,
concluding
electron‐programming
strategy,
extension
conjugated
backbone,
J‐aggregation
strategic
establishment
activatable
fluorophores,
which
enhance
skeletons.
Subsequently,
developments
fluorescent
BODIPY‐based
nanoplatforms
applications
are
intricately
elaborated.
In
conclusion,
this
outlines
future
efforts
directions
refining
meet
evolving
clinical
demands.
It
is
anticipated
that
contribution
may
feasible
reference
thereby
advancing
their
potential
practices.
