ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(32), P. 41916 - 41926
Published: July 31, 2024
Photosensitizer-based
phototherapies,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
offer
safe
treatment
modalities
for
tumor
ablation
with
spatiotemporal
precision.
After
photons
are
absorbed,
PDT
creates
localized
chemical
damage
by
generating
reactive
oxygen
species
(ROS),
while
PTT
induces
thermal
damage.
However,
still
faces
hypoxic
challenges,
encounters
issues
related
to
heat
resistance
potential
overheating.
The
combination
of
shows
great
as
an
effective
anticancer
strategy.
By
targeting
lysosomes
carefully
designed
phototherapeutic
reagents
combined
phototherapy,
rapid
dysfunction
cell
death
in
cancer
cells
can
be
induced,
showing
promise
treatment.
Herein,
two
α–α-linked
bisBODIPYs
tetraphenylethene
(TPE)
moieties
synthesized.
These
TPE-substituted
expand
the
absorption
into
NIR
range
(λmaxabs/λmaxem
∼
740/810
nm)
confer
aggregation-induced
emission
(AIE)
activity
(λmaxem
912
nm).
Moreover,
these
self-assemble
surfactant
F-127
nanoparticles
(NPs),
which
efficiently
generate
ROS
(1O2
•OH)
both
solution
cellular
environments
demonstrate
superior
conversion
efficiencies
(η
68.3%)
along
exceptional
stability.
More
importantly,
NPs
showed
lysosomal
remarkable
murine
models,
indicating
their
precision
therapy.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(1)
Published: Aug. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(35)
Published: April 20, 2023
Photothermal
therapy
(PTT)
has
received
increasing
interest
in
cancer
therapeutics
owing
to
its
excellent
efficacy
and
controllability.
However,
there
are
two
major
limitations
PTT
applications,
which
the
tissue
penetration
depth
of
lasers
within
absorption
range
photothermal
agents
unavoidable
empyrosis
induced
by
high-energy
lasers.
Herein,
a
gas/phototheranostic
nanocomposite
(NA1020-NO@PLX)
is
engineered
that
integrates
second
near-infrared-peak
(NIR-II-peak)
absorbing
aza-boron-dipyrromethenes
(aza-BODIPY,NA1020)
with
thermal-sensitive
nitric
oxide
(NO)
donor
(S-nitroso-N-acetylpenicillamine,
SNAP).
An
enhanced
intramolecular
charge
transfer
mechanism
proposed
achieve
NIR-II-peak
absorbance
(λmax
=
1020
nm)
on
NA1020,
thereby
obtaining
deep
depth.
The
NA1020
exhibits
remarkable
conversion,
making
it
feasible
for
deep-tissue
orthotopic
osteosarcoma
providing
favorable
NIR-II
emission
precisely
pinpoint
tumor
visible
process.
simultaneously
investigated
atraumatic
therapeutic
process
an
cell
apoptosis
indicates
feasibility
synergistic
NO/low-temperature
osteosarcoma.
this
strategy
optimizes
existing
present
repeatable
tumors,
validating
potential
clinical
applications.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(11)
Published: Jan. 16, 2024
Abstract
Achieving
photothermal
therapy
(PTT)
at
ultralow
laser
power
density
is
crucial
for
minimizing
photo‐damage
and
allowing
higher
maximum
permissible
skin
exposure.
However,
this
requires
agents
to
possess
not
just
superior
conversion
efficiency
(PCE),
but
also
exceptional
near‐infrared
(NIR)
absorptivity.
J
‐aggregates,
exhibit
a
significant
redshift
narrower
absorption
peak
with
extinction
coefficient.
Nevertheless,
achieving
predictable
‐aggregates
through
molecular
design
remains
challenge.
In
study,
we
successfully
induced
desirable
J‐
aggregation
(λ
abs
max
:
968
nm,
ϵ:
2.96×10
5
M
−1
cm
,
λ
em
972
Φ
FL
6.2
%)
by
tuning
electrostatic
interactions
between
π‐conjugated
planes
manipulating
surface
potential
of
aromatic
ring‐fused
aza‐BODIPY
dyes.
Notably,
controlling
the
preparation
method
encapsulating
dyes
into
F‐127
polymer,
were
able
selectively
generate
H
‐/
respectively.
Furthermore,
exhibited
two
controllable
morphologies:
nanospheres
nanowires.
Importantly,
shortwave‐infrared
‐aggregated
nanoparticles
impressive
PCE
72.9
%
effectively
destroyed
cancer
cells
mice‐tumors
an
0.27
W
−2
(915
nm).
This
phototherapeutic
nano‐platform,
which
generates
behavior,
can
controllably
form
/
H‐
aggregates
selectable
aggregate
morphology,
valuable
paradigm
developing
tumor‐treatment
density.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(36)
Published: March 29, 2024
Abstract
Fluorescence
imaging
in
the
second
near‐infrared
window
(NIR‐II,
1000–1700
nm)
has
aroused
immense
attention
for
biomedical
applications,
offering
exceptional
advantages
such
as
ultra‐low
photon
scattering
and
increased
tissue
penetration.
Among
NIR‐II‐emitted
organic
dyes,
Boron
dipyrromethene
(BODIPY),
emerged
a
noteworthy
candidate.
BODIPY,
distinguished
by
its
controllable
molecular
structure
optical
properties,
outstanding
fluorescence
quantum
yields,
high
molar
absorption
coefficients,
remarkable
chemical
stability,
undergone
comprehensive
investigation
extensive
exploration
within
realm
of
biological
theranostics.
This
work
aims
to
provide
summary
advancements
development
design
strategies
NIR‐II
BODIPY
fluorophores
tailored
advanced
phototheranostics.
Initially,
elucidates
several
representative
strategies,
concluding
electron‐programming
strategy,
extension
conjugated
backbone,
J‐aggregation
strategic
establishment
activatable
fluorophores,
which
enhance
skeletons.
Subsequently,
developments
fluorescent
BODIPY‐based
nanoplatforms
applications
are
intricately
elaborated.
In
conclusion,
this
outlines
future
efforts
directions
refining
meet
evolving
clinical
demands.
It
is
anticipated
that
contribution
may
feasible
reference
thereby
advancing
their
potential
practices.
