Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 6891 - 6952

Опубликована: Май 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Язык: Английский

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Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

Advanced Materials, Год журнала: 2023, Номер 36(21)

Опубликована: Июль 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Язык: Английский

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Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Advanced Materials, Год журнала: 2024, Номер 36(16)

Опубликована: Янв. 11, 2024

Cancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, starvation therapy, are applied cancer treatment, their limited effect, severe side effects, unsatisfactory drug release behavior need be carefully considered. Thus, there is an urgent develop efficient delivery strategies for improving treatment efficacy realizing on-demand delivery. Notably, pillararenes, emerging class of supramolecular macrocycles, possess unique properties highly tunable structures, superior host-guest chemistry, facile modification, good biocompatibility, which widely used in therapy achieve controllable reduce the toxic effects on normal tissues under internal/external stimuli conditions. This review summarizes recent advance stimuli-responsive systems (SDSs) based pillararenes tumor from perspectives different assembly methods hybrid materials, including molecular-scale SDSs, nano self-assembly systems, nanohybrid SDSs. Moreover, prospects critical challenges SDSs also discussed.

Язык: Английский

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Smart organic materials based on macrocycle hosts

Chemical Society Reviews, Год журнала: 2023, Номер 52(19), С. 6644 - 6663

Опубликована: Янв. 1, 2023

A succinct and illustrative summary of the recent progress supramolecular smart organic materials based on macrocycle hosts is provided spanning aspects design principles, functioning mechanisms, relative applications.

Язык: Английский

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Surface modification strategies in translocating nano-vesicles across different barriers and the role of bio-vesicles in improving anticancer therapy

Journal of Controlled Release, Год журнала: 2023, Номер 363, С. 290 - 348

Опубликована: Сен. 28, 2023

Язык: Английский

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Dual‐Responsive Supramolecular Polymeric Nanomedicine for Self‐Cascade Amplified Cancer Immunotherapy

Advanced Science, Год журнала: 2024, Номер 11(20)

Опубликована: Март 17, 2024

Abstract Insufficient tumor immunogenicity and immune escape from tumors remain common problems in all immunotherapies. Recent studies have shown that pyroptosis, a form of programmed cell death is accompanied by checkpoint inhibitors, can induce effective immunogenic long‐term activation. Therapeutic strategies to jointly pyroptosis reverse immunosuppressive microenvironments are promising for cancer immunotherapy. In this regard, dual‐responsive supramolecular polymeric nanomedicine (NCSNPs) self‐cascade amplify the benefits immunotherapy designed. The NCSNPs formulated β‐cyclodextrin coupling nitric oxide (NO) donor, activator, NLG919, an indoleamine 2,3‐dioxygenase (IDO) inhibitor, self‐assembled through host–guest molecular recognition hydrophobic interaction obtain nanoparticles. possess excellent accumulation bioavailability attributed ingenious engineering. study not only confirms occurrence NO‐triggered first time but also reverses microenvironment sites via IDO inhibitor enhancing infiltration cytotoxic T lymphocytes, achieve remarkable inhibition proliferation. Thus, provides novel strategy

Язык: Английский

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Hypoxia-Responsive Host–Guest Drug Delivery System

Accounts of Materials Research, Год журнала: 2023, Номер 4(11), С. 925 - 938

Опубликована: Окт. 9, 2023

ConspectusA host–guest drug delivery system (HGDDS) refers to a complex of an artificial receptor and therapeutic agent which can dissociate at the lesion site release loaded cargo. Macrocyclic receptors are promising carriers because their superior properties, including ease preparation, precise molecular weight, well-defined structure, excellent chemical stability. The loading process is mild, simple, repeatable. formulations quantitatively load exact cavity-loading pattern quantifiable binding constant. Host–guest typically modular, may be appealing in context personalized medicine macrocyclic act as platform diverse drugs. These lead good batch reproductivity application prospects both scientific research industry. However, order make HGDDS more suitable for practical application, several demands such high affinity, universal multiple drugs, targeting, stimuli-responsiveness still need considered.The hypoxia linked diseases biological processes, cancer, acute chronic diseases, pathogenic microbe infection, other stress responses. As part our ongoing on supramolecular biomaterials based macrocycles by taking advantage recognition assembly we have developed hypoxia-responsive azocalixarenes. azocalixarenes possess deepened cavity, resulting affinities encapsulation efficiencies toward agents. azo group one most frequently employed moieties it reduced under hypoxic microenvironments. This property confers with hypoxia-triggered due remarkable decrease following reduction. fast kinetics further facilitates efficient accumulation drugs site. azocalixarene-based HGDDSs been applied preclinical studies diagnosis treatment tumor, bacterial kidney injury, rheumatoid arthritis.In this Account, outline recent efforts designing formulating We first provide brief introduction HGDDSs, features, quantitative ratiometric models. Then design principles synthesis methods, strong loading, hypoxia-response described. applications treating different followed. Finally, despite rapid development there problems that solved scientifically terms clinical translation. Therefore, propose perspectives conducted HGDDSs.

Язык: Английский

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Designing supramolecular self-assembly nanomaterials as stimuli-responsive drug delivery platforms for cancer therapy

iScience, Год журнала: 2023, Номер 26(3), С. 106279 - 106279

Опубликована: Фев. 27, 2023

Stimuli-responsive nanomaterials have attracted substantial interest in cancer therapy, as they hold promise to deliver anticancer agents tumor sites a precise and on-demand manner. Interestingly, supramolecular chemistry is burgeoning discipline that entails the reversible bonding between components at molecular nanoscale levels, recent advances this area offer possibility design nanotherapeutics with improved controllability functionality for therapy. Herein, we provide comprehensive summary of typical non-covalent interaction modes, which primarily include hydrophobic interaction, hydrogel bonding, host-guest π-π stacking, electrostatic interaction. Special emphasis placed on implications these modes novel stimuli-responsive drug delivery principles concepts, aiming enhance spatial, temporal, dosage precision cells. Finally, future perspectives are discussed highlight current challenges opportunities self-assembly-based nanotechnologies

Язык: Английский

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Pillararene-Based Supramolecular Polymers for Cancer Therapy

Molecules, Год журнала: 2023, Номер 28(3), С. 1470 - 1470

Опубликована: Фев. 3, 2023

Supramolecular polymers have attracted considerable interest due to their intriguing features and functions. The dynamic reversibility of noncovalent interactions endows supramolecular with tunable physicochemical properties, self-healing, externally stimulated responses. Among them, pillararene-based show great potential for biomedical applications fascinating host–guest easy modification. Herein, we summarize the state art cancer therapy illustrate its developmental trend future perspective.

Язык: Английский

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A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy

ACS Nano, Год журнала: 2024, Номер 18(26), С. 16967 - 16981

Опубликована: Июнь 18, 2024

Selective generation of sufficient pyroptosis inducers at the tumor site without external stimulation holds immense significance for a longer duration immunotherapy. Here, we report cascade-amplified inducer CSCCPT/SNAP that utilizes reactive nitrogen species (RNS), self-supplied from diffusion-controlled reaction between oxygen (ROS) and nitric oxide (NO) to potentiate immunotherapy, while both endogenous mitochondrial ROS stimulated by released camptothecin NO initiate pyroptosis. Mechanistically, cascade amplification antitumor immune response is prompted cooperation enhanced RNS with long lifetime, which could be used as trigger effectively compensate inherent drawbacks ROS, resulting in long-lasting favoring Tumor growth efficiently inhibited mouse melanoma tumors through facilitation oxygen/nitrogen (RONS)-NO synergy. In summary, our therapeutic approach supramolecular engineering nanotechnology integrate producers donors tumor-specific stimulus responses into system guarantees synchronous these two elicit pyroptosis-evoked response, using amplifier. RONS-NO synergy achieves sustained robust cancer

Язык: Английский

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