RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
14(12), P. 2438 - 2458
Published: Jan. 1, 2023
One
of
the
world's
serious
health
challenges
is
cancer.
Anti-cancer
agents
delivered
to
normal
cells
and
tissues
pose
several
problems
challenges.
In
this
connection,
photodynamic
therapy
(PDT)
a
minimally
invasive
therapeutic
technique
used
for
selectively
destroying
malignant
while
sparing
tissues.
Development
in
photosensitisers
(PSs)
light
sources
have
be
made
PDT
as
first
option
treatment
patients.
pursuit
developing
new
attractive
molecules
their
formulations
PDT,
researchers
are
working
on
such
type
PSs
that
perform
better
than
those
being
currently
used.
For
widespread
clinical
utilization
effective
particular
importance.
Host-guest
interactions
based
nanographene
assemblies
functionalized
hexa-cata-hexabenzocoronenes,
hexa-peri-hexabenzocoronenes
coronene
attracted
increasing
attention
owing
less
complicated
synthetic
steps
purification
processes
(gel
permeation
chromatography)
during
fabrication.
Noncovalent
provide
easy
facile
approaches
building
supramolecular
enable
them
sensitive
controllable
photoactivities,
which
important
maximizing
effects
minimizing
side
effects.
Various
versatile
cyclodextrins,
cucurbiturils,
calixarenes,
porphyrins
pillararenes
been
designed
order
make
an
curing
cancer
tumours.
The
display
efficient
electron
transfer
fluorescence
use
bioimaging
PDT.
multifunctionalization
designing
biomedically
active
PSs,
helpful
It
anticipated
development
these
will
more
fascinating
advances
dramatically
expand
potential
possibilities
treatments.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(21)
Published: July 21, 2023
Abstract
Chemotherapy
is
widely
recognized
as
an
effective
approach
for
treating
cancer
due
to
its
ability
eliminate
cells
using
chemotherapeutic
drugs.
However,
traditional
chemotherapy
suffers
from
various
drawbacks,
including
limited
solubility
and
stability
of
drugs,
severe
side
effects,
low
bioavailability,
drug
resistance,
challenges
in
tracking
treatment
efficacy.
These
limitations
greatly
hinder
widespread
clinical
application.
In
contrast,
supramolecular
chemotherapy,
which
relies
on
host–guest
interactions,
presents
a
promising
alternative
by
offering
highly
efficient
minimally
toxic
anticancer
delivery.
this
review,
overview
recent
advancements
based
interactions
provided.
The
significant
role
it
plays
guiding
therapy
emphasized.
Drawing
wealth
cutting‐edge
research,
herein,
timely
valuable
resource
individuals
interested
the
field
or
therapy,
presented.
Furthermore,
review
contributes
progression
toward
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(16)
Published: Jan. 11, 2024
Cancer
poses
a
significant
challenge
to
global
public
health,
seriously
threatening
human
health
and
life.
Although
various
therapeutic
strategies,
such
as
chemotherapy
(CT),
radiotherapy,
phototherapy,
starvation
therapy,
are
applied
cancer
treatment,
their
limited
effect,
severe
side
effects,
unsatisfactory
drug
release
behavior
need
be
carefully
considered.
Thus,
there
is
an
urgent
develop
efficient
delivery
strategies
for
improving
treatment
efficacy
realizing
on-demand
delivery.
Notably,
pillararenes,
emerging
class
of
supramolecular
macrocycles,
possess
unique
properties
highly
tunable
structures,
superior
host-guest
chemistry,
facile
modification,
good
biocompatibility,
which
widely
used
in
therapy
achieve
controllable
reduce
the
toxic
effects
on
normal
tissues
under
internal/external
stimuli
conditions.
This
review
summarizes
recent
advance
stimuli-responsive
systems
(SDSs)
based
pillararenes
tumor
from
perspectives
different
assembly
methods
hybrid
materials,
including
molecular-scale
SDSs,
nano
self-assembly
systems,
nanohybrid
SDSs.
Moreover,
prospects
critical
challenges
SDSs
also
discussed.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(19), P. 6644 - 6663
Published: Jan. 1, 2023
A
succinct
and
illustrative
summary
of
the
recent
progress
supramolecular
smart
organic
materials
based
on
macrocycle
hosts
is
provided
spanning
aspects
design
principles,
functioning
mechanisms,
relative
applications.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(20)
Published: March 17, 2024
Abstract
Insufficient
tumor
immunogenicity
and
immune
escape
from
tumors
remain
common
problems
in
all
immunotherapies.
Recent
studies
have
shown
that
pyroptosis,
a
form
of
programmed
cell
death
is
accompanied
by
checkpoint
inhibitors,
can
induce
effective
immunogenic
long‐term
activation.
Therapeutic
strategies
to
jointly
pyroptosis
reverse
immunosuppressive
microenvironments
are
promising
for
cancer
immunotherapy.
In
this
regard,
dual‐responsive
supramolecular
polymeric
nanomedicine
(NCSNPs)
self‐cascade
amplify
the
benefits
immunotherapy
designed.
The
NCSNPs
formulated
β‐cyclodextrin
coupling
nitric
oxide
(NO)
donor,
activator,
NLG919,
an
indoleamine
2,3‐dioxygenase
(IDO)
inhibitor,
self‐assembled
through
host–guest
molecular
recognition
hydrophobic
interaction
obtain
nanoparticles.
possess
excellent
accumulation
bioavailability
attributed
ingenious
engineering.
study
not
only
confirms
occurrence
NO‐triggered
first
time
but
also
reverses
microenvironment
sites
via
IDO
inhibitor
enhancing
infiltration
cytotoxic
T
lymphocytes,
achieve
remarkable
inhibition
proliferation.
Thus,
provides
novel
strategy
iScience,
Journal Year:
2023,
Volume and Issue:
26(3), P. 106279 - 106279
Published: Feb. 27, 2023
Stimuli-responsive
nanomaterials
have
attracted
substantial
interest
in
cancer
therapy,
as
they
hold
promise
to
deliver
anticancer
agents
tumor
sites
a
precise
and
on-demand
manner.
Interestingly,
supramolecular
chemistry
is
burgeoning
discipline
that
entails
the
reversible
bonding
between
components
at
molecular
nanoscale
levels,
recent
advances
this
area
offer
possibility
design
nanotherapeutics
with
improved
controllability
functionality
for
therapy.
Herein,
we
provide
comprehensive
summary
of
typical
non-covalent
interaction
modes,
which
primarily
include
hydrophobic
interaction,
hydrogel
bonding,
host-guest
π-π
stacking,
electrostatic
interaction.
Special
emphasis
placed
on
implications
these
modes
novel
stimuli-responsive
drug
delivery
principles
concepts,
aiming
enhance
spatial,
temporal,
dosage
precision
cells.
Finally,
future
perspectives
are
discussed
highlight
current
challenges
opportunities
self-assembly-based
nanotechnologies
Accounts of Materials Research,
Journal Year:
2023,
Volume and Issue:
4(11), P. 925 - 938
Published: Oct. 9, 2023
ConspectusA
host–guest
drug
delivery
system
(HGDDS)
refers
to
a
complex
of
an
artificial
receptor
and
therapeutic
agent
which
can
dissociate
at
the
lesion
site
release
loaded
cargo.
Macrocyclic
receptors
are
promising
carriers
because
their
superior
properties,
including
ease
preparation,
precise
molecular
weight,
well-defined
structure,
excellent
chemical
stability.
The
loading
process
is
mild,
simple,
repeatable.
formulations
quantitatively
load
exact
cavity-loading
pattern
quantifiable
binding
constant.
Host–guest
typically
modular,
may
be
appealing
in
context
personalized
medicine
macrocyclic
act
as
platform
diverse
drugs.
These
lead
good
batch
reproductivity
application
prospects
both
scientific
research
industry.
However,
order
make
HGDDS
more
suitable
for
practical
application,
several
demands
such
high
affinity,
universal
multiple
drugs,
targeting,
stimuli-responsiveness
still
need
considered.The
hypoxia
linked
diseases
biological
processes,
cancer,
acute
chronic
diseases,
pathogenic
microbe
infection,
other
stress
responses.
As
part
our
ongoing
on
supramolecular
biomaterials
based
macrocycles
by
taking
advantage
recognition
assembly
we
have
developed
hypoxia-responsive
azocalixarenes.
azocalixarenes
possess
deepened
cavity,
resulting
affinities
encapsulation
efficiencies
toward
agents.
azo
group
one
most
frequently
employed
moieties
it
reduced
under
hypoxic
microenvironments.
This
property
confers
with
hypoxia-triggered
due
remarkable
decrease
following
reduction.
fast
kinetics
further
facilitates
efficient
accumulation
drugs
site.
azocalixarene-based
HGDDSs
been
applied
preclinical
studies
diagnosis
treatment
tumor,
bacterial
kidney
injury,
rheumatoid
arthritis.In
this
Account,
outline
recent
efforts
designing
formulating
We
first
provide
brief
introduction
HGDDSs,
features,
quantitative
ratiometric
models.
Then
design
principles
synthesis
methods,
strong
loading,
hypoxia-response
described.
applications
treating
different
followed.
Finally,
despite
rapid
development
there
problems
that
solved
scientifically
terms
clinical
translation.
Therefore,
propose
perspectives
conducted
HGDDSs.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(3), P. 1470 - 1470
Published: Feb. 3, 2023
Supramolecular
polymers
have
attracted
considerable
interest
due
to
their
intriguing
features
and
functions.
The
dynamic
reversibility
of
noncovalent
interactions
endows
supramolecular
with
tunable
physicochemical
properties,
self-healing,
externally
stimulated
responses.
Among
them,
pillararene-based
show
great
potential
for
biomedical
applications
fascinating
host–guest
easy
modification.
Herein,
we
summarize
the
state
art
cancer
therapy
illustrate
its
developmental
trend
future
perspective.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(26), P. 16967 - 16981
Published: June 18, 2024
Selective
generation
of
sufficient
pyroptosis
inducers
at
the
tumor
site
without
external
stimulation
holds
immense
significance
for
a
longer
duration
immunotherapy.
Here,
we
report
cascade-amplified
inducer
CSCCPT/SNAP
that
utilizes
reactive
nitrogen
species
(RNS),
self-supplied
from
diffusion-controlled
reaction
between
oxygen
(ROS)
and
nitric
oxide
(NO)
to
potentiate
immunotherapy,
while
both
endogenous
mitochondrial
ROS
stimulated
by
released
camptothecin
NO
initiate
pyroptosis.
Mechanistically,
cascade
amplification
antitumor
immune
response
is
prompted
cooperation
enhanced
RNS
with
long
lifetime,
which
could
be
used
as
trigger
effectively
compensate
inherent
drawbacks
ROS,
resulting
in
long-lasting
favoring
Tumor
growth
efficiently
inhibited
mouse
melanoma
tumors
through
facilitation
oxygen/nitrogen
(RONS)-NO
synergy.
In
summary,
our
therapeutic
approach
supramolecular
engineering
nanotechnology
integrate
producers
donors
tumor-specific
stimulus
responses
into
system
guarantees
synchronous
these
two
elicit
pyroptosis-evoked
response,
using
amplifier.
RONS-NO
synergy
achieves
sustained
robust
cancer
