Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(28)
Опубликована: Авг. 12, 2023
The
special
redox
homeostasis
of
tumor
cells
makes
reactive
oxygen
species
(ROS)-based
approaches
a
promising
cancer
therapeutic
strategy.
Among
these
approaches,
photodynamic
therapy
is
the
most
widely
studied
ROS-based
treatment
due
to
its
ability
achieve
targeted
by
local
light
irradiation.
However,
achieving
efficient
and
continuous
ROS
generation
without
prolonged
laser
exposure
still
challenging.
In
this
work,
photo-activated
nanoamplifier
proposed
for
photodynamic-chemodynamic
cascade
therapy.
Upon
irradiation,
can
continuously
amplify
cellular
oxidative
stress
through
positive
feedback
loop
"light-triggered
generation,
ROS-responsive
prodrug
activation,
Fenton
reaction-mediated
cyclic
regenerative
amplification",
avoiding
tissue
damage
caused
excessive
exposure.
This
strategy
provides
potential
pathway
overcome
limitations
approaches.
Abstract
Chemodynamic
therapy
(CDT)
shows
immense
potential
in
cancer
treatment
as
it
not
only
directly
kills
tumor
cells
but
also
induces
anti‐tumor
immune
responses.
However,
the
efficacy
of
CDT
is
hampered
by
challenges
targeting
catalysts
specifically
to
tumors
using
nanomaterials,
along
with
limitations
low
H
2
O
levels
and
short
catalyst
duration
within
microenvironment.
In
this
study,
DNA
adjuvant
hydrogel
arrange
a
glucose
oxidase‐ferrocene
cascade
for
continuously
generating
reactive
oxygen
species
(ROS)
from
situ
combined
immunotherapy
employed.
By
precisely
tuning
spacing
double
helix,
ROS
production
efficiency
elevated
up
nine
times
compared
free
catalysts,
resulting
stronger
immunogenetic
cell
death.
Upon
intratumoral
injection,
system
elicited
potent
responses,
thereby
effectively
inhibiting
established
rejecting
re‐challenged
tumors.
This
work
offers
novel
platform
integrated
treatment.
Abstract
Chemodynamic
therapy
(CDT)
has
shown
promising
antitumor
effects
in
various
malignant
tumors.
However,
its
application
for
glioblastoma
(GBM)
is
significantly
hindered
by
the
challenge
of
delivering
CDT
agents
across
blood‐brain
barrier
(BBB)
and
achieving
efficient
tumor
targeting.
To
overcome
these
obstacles,
this
study
presents
a
novel
DNA
nanomachine
(Cu@tFNAs‐G‐A
NM)
loading
copper
ions
(Cu
2+
)
onto
tetrahedral
framework
nucleic
acids
(tFNAs)
functionalized
with
dual
aptamers.
The
aptamers
(GS24
BBB
penetration
AS1411
targeting)
empowered
Cu@tFNAs‐G‐A
NM
ability
to
effectively
penetrate
selectively
accumulate
cells.
Upon
internalization,
loaded
Cu
reacted
tumor‐overexpressed
reductive
glutathione
(GSH)
hydrogen
peroxide
(H
2
O
),
generating
hydroxyl
radicals
(·OH)
inducing
cell
death.
Additionally,
was
found
be
rapidly
cleared
from
brain
normal
tissues
within
24
h,
minimizing
potential
systemic
toxic
side
effects.
These
findings
demonstrate
effective
against
GBM
open
up
new
avenues
development
targeted
therapies
GBM.
Nano Letters,
Год журнала:
2024,
Номер
24(26), С. 8008 - 8016
Опубликована: Июнь 24, 2024
Piezoelectric
dynamic
therapy
(PzDT)
is
an
effective
method
of
tumor
treatment
by
using
piezoelectric
polarization
to
generate
reactive
oxygen
species.
In
this
paper,
two-dimensional
Cu-doped
BiOCl
nanosheets
with
surface
vacancies
are
produced
the
photoetching
strategy.
Under
ultrasound,
a
built-in
electric
field
generated
promote
electron
and
hole
separation.
The
separated
carriers
achieve
O
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
We
have
developed
an
innovative
Cu-doped
and
DTX-loaded
Cu-MnO2@DTX@FA
(MCDF)
nanodrug
designed
to
strategically
alter
tumor
microenvironment
(TME)
by
harnessing
the
synergistic
effects
of
chemodynamic
therapy
(CDT),
chemotherapeutic
agents,
induction
ferroptosis
cuproptosis.
The
MCDF
efficiently
degrades,
releasing
abundant
Mn4+,
Cu2+,
DTX.
conversion
Cu2+
Cu+
facilitated
FDX1
initiates
cuproptosis,
while,
similar
Mn2+,
reacts
with
hydrogen
peroxide
(H2O2)
generate
hydroxyl
radicals
(·OH).
Mn4+
oxidize
glutathione
(GSH),
significantly
depleting
GSH
levels
in
cells
inactivating
GPX4,
which
further
promotes
ferroptosis.
release
intensifies
DTX
effectively
disrupts
cell
division
cycle,
thereby
inhibiting
proliferation
spread
cells.
FA-modified
is
evade
immune
detection
while
selectively
targeting
tissues,
ensuring
precision
treatment
delivery.
This
cutting-edge
material
not
only
provides
a
multifunctional
therapeutic
strategy
but
also
sets
stage
for
next
generation
tumor-targeting
nanomedicines.
Infection
is
the
most
common
complication
after
orthopedic
surgery
and
can
result
in
prolonged
ailments
such
as
chronic
wounds,
enlarged
bone
defects,
osteomyelitis.
Iron,
which
essential
for
bacterial
metabolism
immune
cell
functions,
extremely
important.
Bacteria
harness
iron
from
nearby
cells
to
promote
biofilm
formation,
ensuring
their
survival.
Iron
deficiency
within
infection
microenvironment
(IME)
consequently
hampers
macrophage
function,
enabling
further
dissemination
of
hindering
polarization
M2
phenotype.
Therefore,
a
novel
approach
proposed
regulate
polarization,
aiming
restore
inflammatory
environment.
A
composite
hydrogel
derived
natural
polymers
developed
address
infections
manage
macrophages.
This
IME-responsive
hydrogel,
named
FCL-ECMH,
synthesized
by
encapsulating
vermiculite
functional
core
layers
decellularized
extracellular
matrix
hydrogel.
It
noteworthy
that
FCL-ECMH
produce
reactive
oxygen
species
IME.
Supplementary
photothermal
treatment
enhances
uptake,
leading
ferroptosis-like
death.
process
also
rejuvenates
iron-enriched
macrophages
around
IME,
thereby
enhancing
antibacterial
tissue
repair
functions.
In
vivo
experiments
confirmed
repair-promoting
capabilities
indicating
its
potential
clinical
applications.
