Tailoring p‐Orbital Electron Delocalization Induced by Sulfur Defect Engineering for Enhancing Photoelectrochemical Water Splitting Performance DOI Open Access
Yixuan Gao, Zhaoli Liu, Hua Lü

et al.

Advanced Energy Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Indium sulfide (In 2 S 3 ) as water splitting photocatalyst has been broadly investigated due to its narrow bandgap (2.0–2.3 eV) and optimized opto‐electronic properties. However, In still suffers from a rapid photogenerated charge carrier recombination rate. addition, the main group metals (such In) lack active d ‐orbital electrons for catalysis, thus limits activation of intermediates during catalytic reaction. Herein, overcome above limitations , /TiO heterojunction with sulfur defects are constructed by temperature control strategy. The vacancy (Sv) can induce electron density transformation 5 p localized states delocalized states, which efficiently enhances chemical affinity * OOH. Thus, interaction between O atoms greatly facilitates rate‐determining step ( OOH → +O ), realizing high yield rate 10.00 µmol cm −2 h −1 at 1.23 V versus RHE. Furthermore, heterogeneous structure also enhance interfacial electric field (IEF) stability promoting oxygen generation. This work provides an efficient pathway improve photoelectrochemical (PEC) activity manipulating delocalization through defect engineering.

Language: Английский

DNA Adjuvant Hydrogel‐Optimized Enzymatic Cascade Reaction for Tumor Chemodynamic‐Immunotherapy DOI Creative Commons
Yan Zhao,

Jiangnan Du,

Zihui Xu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(10)

Published: Jan. 15, 2024

Abstract Chemodynamic therapy (CDT) shows immense potential in cancer treatment as it not only directly kills tumor cells but also induces anti‐tumor immune responses. However, the efficacy of CDT is hampered by challenges targeting catalysts specifically to tumors using nanomaterials, along with limitations low H 2 O levels and short catalyst duration within microenvironment. In this study, DNA adjuvant hydrogel arrange a glucose oxidase‐ferrocene cascade for continuously generating reactive oxygen species (ROS) from situ combined immunotherapy employed. By precisely tuning spacing double helix, ROS production efficiency elevated up nine times compared free catalysts, resulting stronger immunogenetic cell death. Upon intratumoral injection, system elicited potent responses, thereby effectively inhibiting established rejecting re‐challenged tumors. This work offers novel platform integrated treatment.

Language: Английский

Citations

9
DNA nanomachine‐driven chemodynamic therapy against glioblastoma DOI Creative Commons

Xiaodie Li,

Yufei Lan, Xin Fu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Chemodynamic therapy (CDT) has shown promising antitumor effects in various malignant tumors. However, its application for glioblastoma (GBM) is significantly hindered by the challenge of delivering CDT agents across blood‐brain barrier (BBB) and achieving efficient tumor targeting. To overcome these obstacles, this study presents a novel DNA nanomachine (Cu@tFNAs‐G‐A NM) loading copper ions (Cu 2+ ) onto tetrahedral framework nucleic acids (tFNAs) functionalized with dual aptamers. The aptamers (GS24 BBB penetration AS1411 targeting) empowered Cu@tFNAs‐G‐A NM ability to effectively penetrate selectively accumulate cells. Upon internalization, loaded Cu reacted tumor‐overexpressed reductive glutathione (GSH) hydrogen peroxide (H 2 O ), generating hydroxyl radicals (·OH) inducing cell death. Additionally, was found be rapidly cleared from brain normal tissues within 24 h, minimizing potential systemic toxic side effects. These findings demonstrate effective against GBM open up new avenues development targeted therapies GBM.

Language: Английский

Citations

9
Cu-Doped MnO2 Nanoparticles Loaded with Docetaxel Synergistically Enhance Chemodynamic Therapy through Ferroptosis and Cuproptosis DOI

Lekang Liu,

Mingbo Shao,

Linna Guo

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We have developed an innovative Cu-doped and DTX-loaded Cu-MnO2@DTX@FA (MCDF) nanodrug designed to strategically alter tumor microenvironment (TME) by harnessing the synergistic effects of chemodynamic therapy (CDT), chemotherapeutic agents, induction ferroptosis cuproptosis. The MCDF efficiently degrades, releasing abundant Mn4+, Cu2+, DTX. conversion Cu2+ Cu+ facilitated FDX1 initiates cuproptosis, while, similar Mn2+, reacts with hydrogen peroxide (H2O2) generate hydroxyl radicals (·OH). Mn4+ oxidize glutathione (GSH), significantly depleting GSH levels in cells inactivating GPX4, which further promotes ferroptosis. release intensifies DTX effectively disrupts cell division cycle, thereby inhibiting proliferation spread cells. FA-modified is evade immune detection while selectively targeting tissues, ensuring precision treatment delivery. This cutting-edge material not only provides a multifunctional therapeutic strategy but also sets stage for next generation tumor-targeting nanomedicines.

Language: Английский

Citations

1
Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion DOI
Xinyang Li, Binbin Ding, Jing Li

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(7), P. 6342 - 6352

Published: March 22, 2024

Language: Английский

Citations

9
Sulfonated vitamin K3 mediated bimetallic metal-organic framework for multistage augmented cancer therapy DOI

Qiaomei Ke,

Peng Jing,

Yehong Wan

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 654, P. 224 - 234

Published: Oct. 11, 2023

Language: Английский

Citations

15
Enhancing lipid peroxidation via radical chain transfer reaction for MRI guided and effective cancer therapy in mice DOI
Juntao Xu, Guoqiang Guan, Zhifei Ye

et al.

Science Bulletin, Journal Year: 2023, Volume and Issue: 69(5), P. 636 - 647

Published: Dec. 19, 2023

Language: Английский

Citations

15
A Multifunctional Tissue‐Engineering Hydrogel Aimed to Regulate Bacterial Ferroptosis‐Like Death and Overcoming Infection Toward Bone Remodeling DOI Creative Commons
Renjie Lu,

Zhiyuan Luo,

Yuanyuan Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 19, 2024

Infection is the most common complication after orthopedic surgery and can result in prolonged ailments such as chronic wounds, enlarged bone defects, osteomyelitis. Iron, which essential for bacterial metabolism immune cell functions, extremely important. Bacteria harness iron from nearby cells to promote biofilm formation, ensuring their survival. Iron deficiency within infection microenvironment (IME) consequently hampers macrophage function, enabling further dissemination of hindering polarization M2 phenotype. Therefore, a novel approach proposed regulate polarization, aiming restore inflammatory environment. A composite hydrogel derived natural polymers developed address infections manage macrophages. This IME-responsive hydrogel, named FCL-ECMH, synthesized by encapsulating vermiculite functional core layers decellularized extracellular matrix hydrogel. It noteworthy that FCL-ECMH produce reactive oxygen species IME. Supplementary photothermal treatment enhances uptake, leading ferroptosis-like death. process also rejuvenates iron-enriched macrophages around IME, thereby enhancing antibacterial tissue repair functions. In vivo experiments confirmed repair-promoting capabilities indicating its potential clinical applications.

Language: Английский

Citations

6
Oxygen Vacancy Piezoelectric Nanosheets Constructed by a Photoetching Strategy for Ultrasound “Unlocked” Tumor Synergistic Therapy DOI

Chenghao Yu,

Yushan Dong, Xingyu Zhu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(26), P. 8008 - 8016

Published: June 24, 2024

Piezoelectric dynamic therapy (PzDT) is an effective method of tumor treatment by using piezoelectric polarization to generate reactive oxygen species. In this paper, two-dimensional Cu-doped BiOCl nanosheets with surface vacancies are produced the photoetching strategy. Under ultrasound, a built-in electric field generated promote electron and hole separation. The separated carriers achieve O

Language: Английский

Citations

6
Boosting the built-in electric field in heterojunctions of 2D and 3D systems to accelerate the separation and transfer of photogenerated carriers for efficient photocatalysis DOI
Li Song, Yanhong Lyu, Jianyun Zheng

et al.

FlatChem, Journal Year: 2024, Volume and Issue: 47, P. 100718 - 100718

Published: July 26, 2024

Language: Английский

Citations

5
Intraparticle Electron Transfer for Long‐Lasting Tumor Chemodynamic Therapy DOI Creative Commons
Jing Yu,

Hongmeng Yan,

Fan Zhao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Chemodynamic therapy (CDT) is a novel tumor treatment method by using hydroxyl radicals (

Language: Английский

Citations

5