Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Ноя. 1, 2023

The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy use tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome stromal barrier for management triple-negative breast cancer (TNBC). SnSNPs possess narrow bandgap (1.18 eV), allowing efficient electron (e-)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, display mild photothermal properties in situ denature collagen facilitate deep into mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by boosts immunity. In mouse models malignant TNBC hepatocellular carcinoma (HCC), combination robust SDT enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. study presents an innovative enhance immunity using strategy, offering potential combined sono-immunotherapy nanomedicine field.

Язык: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Год журнала: 2024, Номер 124(13), С. 8307 - 8472

Опубликована: Июнь 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Язык: Английский

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Biointerface‐Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment

Advanced Materials, Год журнала: 2024, Номер 36(41)

Опубликована: Июнь 9, 2024

Abstract The tumor microenvironment (TME) of typical types such as triple‐negative breast cancer is featured by hypoxia and immunosuppression with abundant tumor‐associated macrophages (TAMs), which also emerge potential therapeutic targets for antitumor therapy. M1‐like macrophage‐derived exosomes (M1‐Exos) have emerged a promising candidate their tumor‐targeting macrophage‐polarization capabilities. However, the limited drug‐loading efficiency stability M1‐Exos hindered effectiveness in applications. Here, hybrid nanovesicle developed integrating AS1411 aptamer‐conjugated liposomes (AApt‐Lips), termed M1E/AALs. obtained M1E/AALs are loaded perfluorotributylamine (PFTBA) IR780, P‐I, to construct P‐I@M1E/AALs reprogramming TME alleviating engineering TAMs. P‐I@M1E/AAL‐mediated therapy enhances situ generation reactive oxygen species, repolarizes TAMs toward an phenotype, promotes infiltration T lymphocytes. synergistic based on significantly suppresses growth prolongs survival 4T1‐tumor‐bearing mice. By multiple treatment modalities, P‐I@M1E/AAL nanoplatform demonstrates approach overcoming hypoxic immunosuppressive targeted TAM enhanced photodynamic immunotherapy. This study highlights innovative TAM‐engineering platform tumors characterized TME.

Язык: Английский

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Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities

Frontiers in Chemistry, Год журнала: 2025, Номер 12

Опубликована: Янв. 15, 2025

Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections resulting in alarmingly increasing rates of morbidity mortality. Plant derived compounds hold numerous antimicrobial properties, them very capable source counteract microbial strains. Syzygium aromaticum (Clove) extract has been proven by studies contain active ingredients that demonstrate antibacterial, antifungal, antioxidant, insecticidal properties. It also used historically for its pain relief especially tooth ache. Clove nanoparticle synthesis is promising method combining therapeutics with metals at nanoscale. Such nanostructured systems combination the heterocyclic antibiotic clarithromycin could potentiate action plant extracts, decrease drug side effects improve activity. In this study, clove (C) was successfully synthesize silver nanoparticles (AgNP) create AgNPC AgNPCA (A = clarithromycin). The two underwent different analytical methods consisting SEM, EDS, DLS, UV-vis, FTIR XRD. These were against variety 10 pathogens exhibited good intermediate antibacterial resulted better properties smaller size. This study demonstrates potential mediated AgNP without clarithromycin.

Язык: Английский

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Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 1, 2025

Язык: Английский

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Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

Background In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits ability of immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able reprogram TAMs towards M1-like antitumor effector cells. The objective our work has been develop and evaluate polymeric nanocapsules (NCs) loaded with poly(I:C)+R848, improve drug stability systemic toxicity, their targeting therapeutic activity in TME solid tumors. Methods NCs were developed by solvent displacement layer-by-layer methodologies characterized dynamic light scattering nanoparticle tracking analysis. Hyaluronic acid (HA) was chemically functionalized mannose for coating target TAMs. TLR ligands evaluated vitro toxicity immunostimulatory Alamar Blue, ELISA flow cytometry, using primary human monocyte-derived macrophages. For vivo experiments, CMT167 lung cancer model MN/MCA1 fibrosarcoma metastasizing lungs used; tumor-infiltrating leukocytes cytometry multispectral immunophenotyping. Results We have poly(I:C)+R848. Among series 5 lead prototypes, protamine-NCs selected based on physicochemical properties (size, charge, stability) characterization, showing good biocompatibility stimulate production T-cell attracting chemokines (CXCL10, CCL5) induce cytotoxicity mouse models, intratumoral injection poly(I:C)+R848-protamine-NCs significantly prevented growth metastasis. an orthotopic murine model, intravenous administration poly(I:C)+R848-prot-NCs, coated additional layer HA-mannose TAM-targeting, resulted antitumoral efficacy no apparent toxicity. While significant alterations observed T cell numbers (CD8, CD4 Treg), TAM-reprogramming treated mice confirmed relative decrease interstitial versus alveolar macrophages, having higher CD86 expression but lower CD206 Arg1 same cells, mice. Conclusion Mannose-HA-protamine-NCs poly(I:C)+R848 successfully , reduce progression metastasis spread

Язык: Английский

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A Ferroptosis‐Inducing Arsenene‐Iridium Nanoplatform for Synergistic Immunotherapy in Pancreatic Cancer

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(15)

Опубликована: Фев. 13, 2024

Due to multidrug resistance and the high risk of recurrence, effective less toxic alternative pancreatic cancer treatments are urgently needed. Pancreatic cells highly resistant apoptosis but sensitive ferroptosis. In this study, an innovative nanoplatform (AsIr@PDA) was developed by electrostatic adsorption a cationic iridium complex (IrFN) onto two-dimensional (2D) arsenene nanosheets. This exhibits superior ferroptosis-inducing effects with drug loading capacity and, importantly, excellent anti-cancer immune activation function, leading efficient elimination tumors no observable side effects. Interestingly, AsIr@PDA significantly prevents recurrence in vivo when compared cisplatin-loaded nanoplatform. designed demonstrated therapeutic efficacy synergistic ferroptosis-induced chemotherapy immunotherapy via all-in-one strategy, providing new insights for future therapy.

Язык: Английский

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Periodic Table of Immunomodulatory Elements and Derived Two‐Dimensional Biomaterials

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Abstract Periodic table of chemical elements serves as the foundation material chemistry, impacting human health in many different ways. It contributes to creation, growth, and manipulation functional metallic, ceramic, metalloid, polymeric, carbon‐based materials on near an atomic scale. Recent nanotechnology advancements have revolutionized field biomedical engineering tackle longstanding clinical challenges. The use nano‐biomaterials has gained traction medicine, specifically areas nano‐immunoengineering treat inflammatory infectious diseases. Two‐dimensional (2D) nanomaterials been found possess high bioactive surface area compatibility with mammalian cells at controlled doses. Furthermore, these biomaterials intrinsic immunomodulatory properties, which is crucial for their application immuno‐nanomedicine. While significant progress made understanding bioactivity biocompatibility, exact responses mechanisms are still being explored. Current work outlines innovative “immunomodulatory periodic elements” beyond life, microbial genomics comprehensively reviews role each element designing immunoengineered 2D a group‐wise manner. recapitulates most recent advances nanomaterials, paving way development new mono, hybrid, composite, hetero‐structured biomaterials.

Язык: Английский

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Nanotechnology-based biomedical devices in the cancer diagnostics and therapy

Medical Oncology, Год журнала: 2025, Номер 42(2)

Опубликована: Янв. 20, 2025

Язык: Английский

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Harnessing nanotechnology for cancer treatment

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12

Опубликована: Янв. 20, 2025

Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at nanoscale, researchers have developed nanocarriers capable targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, polymeric nanomaterials shown significant promise delivering chemotherapeutic agents directly tumor sites, enhancing bioavailability minimizing damage healthy tissues. In addition with utilization tools quantum dots nanosensors that enables more precise identification biomarkers, nanotechnology is also playing pivotal role early detection diagnosis. Furthermore, nanotechnology-based strategies, including photothermal gene therapy immunotherapy are novel ways combat by selectively targeting cells immune response. Nevertheless, despite these progressions, obstacles still persist, particularly clinical translation technologies. Issues nanoparticle toxicity, biocompatibility, complexity regulatory approval hinder widespread adoption nanomedicine oncology. This review discusses different applications highlighting its potential hurdles implementation. Future research needs concentrate on addressing unlock full providing personalized, effective, minimally invasive treatments.

Язык: Английский

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