Glutathione‐Scavenging Celastrol‐Cu Nanoparticles Induce Self‐Amplified Cuproptosis for Augmented Cancer Immunotherapy

Advanced Materials, Год журнала: 2024, Номер 36(35)

Опубликована: Июнь 27, 2024

Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis highly dependent on intracellular copper accumulation and counteracted by high level glutathione (GSH) in tumor cells. Here, this work develops self-amplified nanoparticles (Cel-Cu NP) using celastrol (Cel), natural product isolated from medical plant. In Cel-Cu NP, Cel serves as versatile ionophore, exhibiting an ideal coordination capacity toward ions without compromising the induction. Notably, can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, further activates immunogenic death (ICD) elicit robust immune response. Combining with checkpoint blockade, NP effectively eradicates metastatic tumors mouse lung metastasis model. This study provides efficient nanomedicine inducing for immunotherapy.

Язык: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Год журнала: 2024, Номер 124(13), С. 8307 - 8472

Опубликована: Июнь 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Язык: Английский

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Enhancing Fractionated Cancer Therapy: A Triple-Anthracene Photosensitizer Unleashes Long-Persistent Photodynamic and Luminous Efficacy

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(9), С. 6252 - 6265

Опубликована: Фев. 20, 2024

Conventional photodynamic therapy (PDT) is often limited in treating solid tumors due to hypoxic conditions that impede the generation of reactive oxygen species (ROS), which are critical for therapeutic efficacy. To address this issue, a fractionated PDT protocol has been suggested, wherein light irradiation administered stages separated by dark intervals permit recovery during these breaks. However, current photosensitizers used incapable sustaining ROS production intervals, leading suboptimal outcomes (Table S1). circumvent drawback, we have synthesized novel photosensitizer based on triple-anthracene derivative designed prolonged generation, even after cessation exposure. Our study reveals unique action derivatives, facilitating direct and effective disruption biomolecules significantly improving efficacy S2). Moreover, existing lack imaging capabilities monitoring, constraints fine-tuning parameters also serves as an afterglow agent, emitting sustained luminescence postirradiation. This function allows precise optimization between sessions aids determining timing subsequent irradiation, thus enabling meticulous control over parameters. Utilizing our photosensitizer, formulated regimen effectively eliminates orthotopic pancreatic tumors. investigation highlights promise employing long-persistent activity advanced approaches overcome limitations tumor treatment.

Язык: Английский

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Biointerface‐Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment

Advanced Materials, Год журнала: 2024, Номер 36(41)

Опубликована: Июнь 9, 2024

Abstract The tumor microenvironment (TME) of typical types such as triple‐negative breast cancer is featured by hypoxia and immunosuppression with abundant tumor‐associated macrophages (TAMs), which also emerge potential therapeutic targets for antitumor therapy. M1‐like macrophage‐derived exosomes (M1‐Exos) have emerged a promising candidate their tumor‐targeting macrophage‐polarization capabilities. However, the limited drug‐loading efficiency stability M1‐Exos hindered effectiveness in applications. Here, hybrid nanovesicle developed integrating AS1411 aptamer‐conjugated liposomes (AApt‐Lips), termed M1E/AALs. obtained M1E/AALs are loaded perfluorotributylamine (PFTBA) IR780, P‐I, to construct P‐I@M1E/AALs reprogramming TME alleviating engineering TAMs. P‐I@M1E/AAL‐mediated therapy enhances situ generation reactive oxygen species, repolarizes TAMs toward an phenotype, promotes infiltration T lymphocytes. synergistic based on significantly suppresses growth prolongs survival 4T1‐tumor‐bearing mice. By multiple treatment modalities, P‐I@M1E/AAL nanoplatform demonstrates approach overcoming hypoxic immunosuppressive targeted TAM enhanced photodynamic immunotherapy. This study highlights innovative TAM‐engineering platform tumors characterized TME.

Язык: Английский

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Defect‐Repaired g‐C₃N₄ Nanosheets: Elevating the Efficacy of Sonodynamic Cancer Therapy Through Enhanced Charge Carrier Migration

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(18)

Опубликована: Фев. 7, 2024

Sonodynamic therapy (SDT) has garnered growing interest owing to its high tissue penetration depth and minimal side effects. However, the lack of efficient sonosensitizers remains primary limiting factor for clinical application this treatment method. Here, defect-repaired graphene phase carbon nitride (g-C

Язык: Английский

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Chemoimmunotherapeutic Nanogel for Pre- and Postsurgical Treatment of Malignant Melanoma by Reprogramming Tumor-Associated Macrophages

Nano Letters, Год журнала: 2024, Номер 24(5), С. 1717 - 1728

Опубликована: Янв. 25, 2024

Surgery is the primary method to treat malignant melanoma; however, residual microtumors that cannot be resected completely often trigger tumor recurrence, causing tumor-related mortality following melanoma resection. Herein, we developed a feasible strategy based on combinational chemoimmunotherapy by cross-linking carboxymethyl chitosan (CMCS)-originated polymetformin (PolyMetCMCS) with cystamine prepare stimuli-responsive nanogel (PMNG) owing disulfide bond in can cleaved massive glutathione (GSH) sites. Then, chemotherapeutic agent doxorubicin (DOX) was loaded PMNG, which followed hyaluronic acid coating improve overall biocompatibility and targeting ability of prepared (D@HPMNG). Notably, PMNG effectively reshaped immune microenvironment reprogramming tumor-associated macrophage phenotypes recruiting intratumoral CD8+ T cells inherited immunomodulatory capability metformin. Consequently, D@HPMNG treatment remarkably suppressed growth inhibited its recurrence after surgical resection, proposing promising solution for overcoming lethal recurrence.

Язык: Английский

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Carrier-free nanoparticles for cancer theranostics with dual-mode magnetic resonance imaging/fluorescence imaging and combination photothermal and chemodynamic therapy

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125285 - 125285

Опубликована: Янв. 1, 2025

Язык: Английский

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Advances in covalent organic frameworks for cancer phototherapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215720 - 215720

Опубликована: Фев. 16, 2024

Язык: Английский

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Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics

BMEMat, Год журнала: 2024, Номер unknown

Опубликована: Март 4, 2024

Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.

Язык: Английский

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Sulfur-Vacancy-Engineered Two-Dimensional Cu@SnS_2–x Nanosheets Constructed via Heterovalent Substitution for High-Efficiency Piezocatalytic Tumor Therapy

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(31), С. 21496 - 21508

Опубликована: Июль 29, 2024

Ultrasound (US)-mediated piezocatalytic tumor therapy has attracted much attention due to its notable tissue-penetration capabilities, noninvasiveness, and low oxygen dependency. Nevertheless, the efficiency of is limited an inadequate piezoelectric response, separation electron–hole (e––h+) pairs, complex microenvironment (TME). Herein, ultrathin two-dimensional (2D) sulfur-vacancy-engineered (Sv-engineered) Cu@SnS2–x nanosheet (NS) with enhanced effect was constructed via heterovalent substitution strategy Sn4+ by Cu2+. The introduction Cu2+ ion not only causes changes in crystal structure increase polarization but also generates rich Sv decrease band gap from 2.16 1.62 eV inhibit e––h+ pairs recombination, collectively leading highly efficient generation reactive species under US irradiation. Moreover, shows US-enhanced TME-responsive Fenton-like catalytic activity glutathione depletion ability, further aggravating oxidative stress. Both vitro vivo results prove that Sv-engineered NSs can significantly kill cells achieve high-efficiency a biocompatible manner. Overall, this study provides new avenue for sonocatalytic broadens application 2D materials.

Язык: Английский

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