Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 519, С. 216122 - 216122

Опубликована: Авг. 6, 2024

Язык: Английский

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Interstitial Optical Fiber‐Mediated Multimodal Phototheranostics Based on an Aggregation‐Induced NIR‐II Emission Luminogen for Orthotopic Breast Cancer Treatment

Advanced Materials, Год журнала: 2024, Номер 36(38)

Опубликована: Июль 26, 2024

Abstract One‐for‐all phototheranostics based on a single molecule is recognized as convenient approach for cancer treatment, whose efficacy relies precise lesion localization through multimodal imaging, coupled with the efficient exertion of phototherapy. To unleash full potential phototheranostics, advancement in both phototheranostic agents and light delivery methods essential. Herein, an integrated strategy combining versatile featuring aggregation‐induced emission, namely tBuTTBD, modified optical fiber to realize comprehensive tumor diagnosis “inside‐out” irradiation orthotopic breast tumor, proposed first time. Attributed intense donor‐acceptor interaction, highly distorted conformation, abundant molecular rotors, loose intermolecular packing upon aggregation, tBuTTBD can synchronously undergo second near‐infrared (NIR‐II) fluorescence photothermal photodynamic generation under laser irradiation, contributing trimodal NIR‐II fluorescence‐photoacoustic (PA)‐photothermal imaging‐guided The treatment further carried out following insertion fiber, which fabricated by splicing flat‐end air‐core fiber. This configuration aims enable effective situ phototherapy maximizing energy utilization therapeutic benefits. work not only enriches palette but also provides valuable insight exploring protocol practical treatment.

Язык: Английский

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Biomarker-activatable photosensitizers with aggregation-induced emission characteristics for photodynamic therapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 518, С. 216056 - 216056

Опубликована: Июль 3, 2024

Язык: Английский

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NIR‐II Fluorescence Sensor Based on Steric Hindrance Regulated Molecular Packing for In Vivo Epilepsy Visualization

Angewandte Chemie, Год журнала: 2024, Номер 136(26)

Опубликована: Апрель 19, 2024

Abstract Fluorescence sensing is crucial to studying biological processes and diagnosing diseases, especially in the second near‐infrared (NIR‐II) window with reduced background signals. However, it's still a great challenge construct “off‐on” sensors when wavelength extends into NIR‐II region obtain higher imaging contrast, mainly due difficult synthesis of spectral overlapped quencher. Here, we present new fluorescence quenching strategy, which utilizes steric hindrance quencher (SHQ) tune molecular packing state fluorophores suppress emission signal. Density functional theory (DFT) calculations further reveal that large SHQs can competitively pack prevent their self‐aggregation. Based on this mechanism, novel activatable method achieved via bio‐analyte responsive invalidation SHQ, namely Steric Hindrance Invalidation geNerated Emission (SHINE) strategy. As proof concept, ClO − ‐sensitive SHQ lead bright signal release epileptic mouse hippocampus under skull high photon scattering brain tissue, providing real‐time visualization generation process living mice.

Язык: Английский

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Construction of Through‐Space Charge‐Transfer Nanoparticles for Facilely Realizing High‐Performance NIR‐II Cancer Phototheranostics

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

Abstract Phototheranostics with second near‐infrared (NIR‐II) emissions show great potential for disease diagnosis and imaging‐guided phototherapy owing to deep tissue penetration, high imaging resolution, excellent tumor eradication. Recently, molecular conjugation engineering J‐aggregation have been used construct organic NIR‐II materials. However, these molecules generally extensive large weight in the range of 700–1700 g mol −1 , requiring complicated design synthesis. Herein, a emissive through‐space charge‐transfer (TSCT) nanoparticle (NP) using short‐conjugated donor‐acceptor (D‐A) (TTP) is reported high‐performance bioimaging cancer phototheranostics. Owing short TTP molecule small only 518 monomer possesses visible absorption first (NIR‐I) emission. Upon forming NPs water, efficient TSCT between monomers leads significantly red‐shifted NIR‐I emission region tail that extends 1400 nm. are employed vivo blood‐vessel phototheranostics successfully. This work introduces facile strategy based on D‐A biomedical applications.

Язык: Английский

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NIR‐II Fluorescence Sensor Based on Steric Hindrance Regulated Molecular Packing for In Vivo Epilepsy Visualization

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(26)

Опубликована: Апрель 19, 2024

Fluorescence sensing is crucial to studying biological processes and diagnosing diseases, especially in the second near-infrared (NIR-II) window with reduced background signals. However, it's still a great challenge construct "off-on" sensors when wavelength extends into NIR-II region obtain higher imaging contrast, mainly due difficult synthesis of spectral overlapped quencher. Here, we present new fluorescence quenching strategy, which utilizes steric hindrance quencher (SHQ) tune molecular packing state fluorophores suppress emission signal. Density functional theory (DFT) calculations further reveal that large SHQs can competitively pack prevent their self-aggregation. Based on this mechanism, novel activatable method achieved via bio-analyte responsive invalidation SHQ, namely Steric Hindrance Invalidation geNerated Emission (SHINE) strategy. As proof concept, ClO

Язык: Английский

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Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

The development of phototherapeutics with high photothermal conversion efficiency (PCE) and strong ability to generate reactive oxygen species under single near-infrared (NIR) laser irradiation for immuno-phototherapy applications remains a significant challenge. Herein, we optimally selected the molecule IT-4F an acceptor-donor-acceptor (A-D-A) structure prepare water-dispersible nanoparticles (NPs) by assembly DSPE-PEG-NH₂. Such NPs have NIR absorption fluorescence peaks at 728 817 nm, respectively. They can singlet (¹O₂) superoxide anion (O₂^-·) irradiation, ¹O₂ generation quantum yield 31.5%. also effectively convert photon-energy into heat PCE 42.8%. outstanding properties enable them be used in imaging guided therapy (PTT), photodynamic (PDT). Moreover, PDT PTT triggered immunogenic cell death PANoptosis tumor cells, which not only inhibited growth metastasis mice model, but induced robust immune response, evidenced increased infiltration CD8⁺ T CD4⁺ dendritic decreased presence immunosuppressive cells such as myeloid-derived suppressor regulatory cells. efficacy organoid human breast cancer was verified.

Язык: Английский

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Dendritic donor engineering to optimize second near-infrared photothermal agents for in situ photothermal therapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 689, С. 137190 - 137190

Опубликована: Март 7, 2025

Язык: Английский

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AIE and ICT Synergistic Lysosome-Targeted Ratiometric Fluorescence Sensor for the Detection and Imaging of Th⁴⁺ in the Liver of Zebrafish and Mice

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

The sensitive detection of the radioactive thorium (Th) ion with an oxidation state +4 (Th4+) is great significance for environmental protection and life safety. In this study, five fluorescence sensors regulated donor-acceptor (D-A) interactions were constructed Th4+ based on intramolecular charge transfer aggregation-induced emission mechanisms. Among developed sensors, TPE-D bearing electron-deficient π-bridge weak D-A presented ratiometric behavior toward in aqueous solution due to its characteristics unique D-A-D structures. Moreover, showed excellent selectivity sensitivity detection, limit was as low 8.1 × 10-8 M. sensing mechanism observation revealed that could coordinate hydroxyl, imine, carbonyl groups accompanied by electron process. addition, selectively be enriched lysosome. Both lysosome liver mice zebrafish realized strategy, a mobile-assisted approach actual water samples also established high sensitivity. This first report organelles organs, which provides reliable strategy radionuclide toxicology analysis applications.

Язык: Английский

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Advances on fluorescence bioimaging and photo-mediated therapy of NIR-II small molecule dyes

Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216587 - 216587

Опубликована: Март 14, 2025

Язык: Английский

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