Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Cell Biochemistry and Function, Год журнала: 2024, Номер 42(1)

Опубликована: Янв. 1, 2024

Abstract Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness limited due to poor absorption rapid elimination the body. Various curcumin derivatives have also shown anticancer potential in‐vitro in‐vivo models. multiple signaling pathways development/progression or induce cell death through apoptosis. In addition, could enhance of conventional chemotherapy, radiation therapy reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored overcome challenges with curcumin's delivery, increasing overall efficacy. The use an imaging system track these formulations give beneficial information about bioavailability distribution nano‐curcumin complex. conclusion, holds significant promise fight against cancer, especially nanoform, provide precise cells without affecting normal healthy cells.

Язык: Английский

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Synergistic therapeutic strategies and engineered nanoparticles for anti-vascular endothelial growth factor therapy in cancer

Life Sciences, Год журнала: 2024, Номер 341, С. 122499 - 122499

Опубликована: Фев. 10, 2024

Язык: Английский

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In vitro cytotoxicity assessment of biosynthesized nanoceria against MCF-7 breast cancer cell lines

Applied Surface Science Advances, Год журнала: 2024, Номер 21, С. 100603 - 100603

Опубликована: Апрель 17, 2024

Breast cancer poses a significant health concern due to its increasing prevalence and mortality rates. Hence, prompt action is needed develop innovative therapeutic interventions, as conventional treatments exhibit severe adverse effects have limited efficacy. This study aims an intervention for breast using biosynthesized nanoceria. Nanoceria has gained importance in the medicinal field biocompatibility, dual capabilities both antioxidant prooxidant, specific cytotoxicity towards cells. Herein, nanoceria was Echinochloa frumentaceae grain extract (EFNC) eco-friendly cost-efficient nature, it systematically investigated standard characterization techniques. Furthermore, their anticancer efficacy against MCF-7 cell lines studied 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) viability assay, occurrence of apoptosis determined acridine orange/ethidium (AO/EtBr) staining. Significantly, EFNC exhibited superior even at lower concentrations (10 µg/mL), IC50 value found 47.32 µg/mL. In addition, observed bright green orange-red fluorescence, along with fragmented/condensed chromatin features AO/EtBr staining clearly indicated that caused death through apoptotic route. One potential factor contributing effectiveness could be prooxidant properties within These ultimately enhanced oxidative stress, induced accumulation reactive oxygen species (ROS), led apoptosis. vitro analysis substantiated EFNC, suggesting utility promising agent treatment. findings pave way further exploration development valuable candidate addressing cancer-related challenges.

Язык: Английский

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Green biosynthesis of bimetallic selenium–gold nanoparticles using Pluchea indica leaves and their biological applications

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 11

Опубликована: Янв. 11, 2024

Increasing bacterial resistance and the negative impact of currently used antibacterial agents have produced need for novel anticancer drugs. In this regard, nanotechnology could provide safer more efficient therapeutic agents. The main methods nanoparticle production are chemical physical approaches that often costly environmentally unsafe. current study, Pluchea indica leaf extract was biosynthesis bimetallic selenium–gold nanoparticles (Se-Au BNPs) first time. Phytochemical examinations revealed P. includes 90.25 mg/g dry weight (DW) phenolics, 275.53 DW flavonoids, 26.45 tannins. X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), scanning (SEM), energy-dispersive spectroscopy (EDX) techniques were employed to characterize Se-Au BNPs. Based on UV-vis spectra, absorbance BNPs peaked at 238 374 nm. SEM imaging, emerged as bright particles, both Au Se uniformly distributed throughout extract. XRD analysis average size 45.97 showed properties against Escherichia coli , Pseudomonas aeruginosa Staphylococcus aureus Bacillus subtilis with minimum inhibitory concentrations (MICs) 31.25, 15.62, 3.9 μg/mL, respectively. Surprisingly, a cytotoxicity assay IC 50 value toward Wi 38 normal cell line 116.8 implying all MICs described above be safely. More importantly, shown higher efficacy human breast cancer cells (MCF7), an 13.77 μg/mL. conclusion, paper is data effective utilization in biologically active

Язык: Английский

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Green synthesis of CuO nanoparticle using Cyperus rotundus and evaluation of their anticancer potentials against lung cancer cells invitro

Biocatalysis and Agricultural Biotechnology, Год журнала: 2024, Номер 57, С. 103119 - 103119

Опубликована: Март 20, 2024

Язык: Английский

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Copper homeostasis and cuproptosis in gynecological disorders: Pathogenic insights and therapeutic implications

Journal of Trace Elements in Medicine and Biology, Год журнала: 2024, Номер 84, С. 127436 - 127436

Опубликована: Март 18, 2024

Язык: Английский

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Preparation, characterization, and in vitro evaluation of the anticancer activity of Ce3+ doped CuFe2O4 spinel nanoparticles in MCF-7 cell lines

Chemical Physics Impact, Год журнала: 2023, Номер 8, С. 100423 - 100423

Опубликована: Дек. 10, 2023

In the present study, we successfully prepared nanoparticles of Ce-doped Copper ferrite, CuCexFe2-xO4(x=0.00, 0.03, and 0.05), in nanoscale using chemical co-precipitation technique. The structure, composition, optical properties, morphological information obtained ferrite (NPs) were analyzed by making use powder X-ray diffraction (PXRD) pattern, Field Emission Scanning Electron Microscopic (FE-SEM) studies, Fourier Transform Infrared Spectroscopic (FT-IR) analysis, Energy-dispersive X-Ray Spectroscopy (EDS), UV-Vis-NIR Spectroscopy. cytotoxicity CuCexFe2-xO4 on MCF-7 breast cancer cell line was evaluated MTT assay. NPs exhibited dose-dependent cytotoxicity, with lower concentrations (<25 µg/mL) being safe biocompatible, while higher reduced viability disrupted L929 fibroblast lines. Double staining flow cytometry experiments revealed that apoptosis is one mechanisms which induce cells. An increase reactive oxygen species (ROS) found presence NPs. To harness full potential this nanoparticle formulation, it recommended future investigations encompass a wide range vitro vivo models. These subsequent studies will significantly contribute to expanding body knowledge concerning synthesis composite formulations for as anticancer agents.

Язык: Английский

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Novel Drug Delivery Systems in Colorectal Cancer: Advances and Future Prospects

Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155546 - 155546

Опубликована: Авг. 22, 2024

Язык: Английский

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Insights into the apoptosis induction in colon cancer cells by Ag-Cu bimetallic nanocomposite: 2D tissue culture model and insilico study

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114019 - 114019

Опубликована: Янв. 1, 2025

Язык: Английский

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Nano‐Encapsulated Coumarin Derivative, CS‐QM2 Inhibits Neoplasm Growth: Experimented in Zebrafish Model

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(4)

Опубликована: Март 27, 2025

Cancer remains a significant global health challenge with limited therapeutic success, prompting the need for innovative treatment strategies. This study investigates anticancer potential of nano-encapsulated metal derivatives (CS-QM2) using zebrafish model chemically induced cellular neoplasia. Characterization CS-QM2 nanoparticles revealed successful synthesis high entrapment efficiency and enhanced drug release under acidic conditions. Zebrafish embryos exposed to 7,12-Dimethylbenz[a]anthracene (DMBA) exhibited malformations, macrophage accumulation, abnormal tissue growth, which were markedly reduced by treatment. significantly increases intracellular ROS, resulting in higher LPO induces apoptosis neoplasm tissues. Furthermore, alters tumor microenvironment, reducing accumulation decreasing neutral lipid droplets, disrupting TAM metabolic support limiting their protumorigenic activities. Biochemical assays demonstrated restored activities antioxidant enzymes SOD, CAT, GSH. Gene expression analysis showed upregulation suppressor genes (cas3, p53) downregulation inflammatory (cox-2, nf-kb). Histological assessment SEM confirmed occurrence abnormalities. These findings suggest that effectively inhibit growth modulate microenvironment through oxidative stress induction gene regulation.

Язык: Английский

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