ChemistrySelect, Год журнала: 2023, Номер 8(31)
Опубликована: Авг. 16, 2023
Abstract The C=C double bond cleavage of enaminones has been accomplished in the presence methyl sulfonyl azide (MSA) to provide α‐hydroxyl ketones via reaction with water. major process reactions consists formation a key α‐diazoketone intermediate resulting from enaminone‐azide annulation, and successive decomposition. Totally 22 have synthesized yield range 43 %–83 %.
Язык: Английский
Chemical Science, Год журнала: 2023, Номер 14(25), С. 6841 - 6859
Опубликована: Янв. 1, 2023
The selective functionalization of alkanes has long been recognized as a prominent challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) processes enable the direct generation reactive alkyl radicals from feedstock have successfully employed industrial applications such methane chlorination process,
Язык: Английский
Процитировано
72
Organic Letters, Год журнала: 2023, Номер 25(47), С. 8451 - 8456
Опубликована: Ноя. 16, 2023
The three-component reactions of enaminones, disulfides, and alcohols for the synthesis polyfunctionalized alkenes have been realized via C-H C-N bond transformation on enaminones. proceed in a novel "alkene-to-alkene" difunctionalization mode without using any transition metal. application alkene products divergent sulfenyl heteroaryls, including sulfenylated pyrazoles, pyrimidines, isoxazoles, simple annulation has also verified.
Язык: Английский
Процитировано
29
Chinese Journal of Chemistry, Год журнала: 2023, Номер 41(17), С. 2179 - 2196
Опубликована: Апрель 25, 2023
Comprehensive Summary The trifluoromethoxy functional group has received increasing attention in recent years due to its distinctive properties such as good metabolic stability, appropriate lipophilicity and special electrical properties. Thus, the development of new reagents strategies direct trifluoromethoxylation are attracting enthusiasm many fluorine chemical workers. At present, nucleophilic radical trifluoromethoxylating have made major breakthroughs, greatly promoting chemistry. This review is mainly divided into two parts: types, focusing on history, characteristics applications various reagents.
Язык: Английский
Процитировано
25
Chinese Chemical Letters, Год журнала: 2024, Номер 35(11), С. 109683 - 109683
Опубликована: Март 2, 2024
Язык: Английский
Процитировано
16
Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(15), С. 1679 - 1685
Опубликована: Март 15, 2024
Comprehensive Summary A novel and eco‐friendly electrochemical activation of trifluoromethyl thianthrenium triflate (TT–CF 3 + OTf − ) for trifluoromethylation imidazole‐fused heteroaromatic compounds was established. This method involves the direct electrolysis TT–CF without requirement external oxidants or catalysts, aligning with principles green chemistry. wide range including imidazo[1,2‐ a ]pyridines benzo[ d ]imidazo[2,1‐ b ]thiazoles have been successfully trifluoromethylated using this technique, exhibiting excellent compatibility various functional groups broad substrate scope. Moreover, method's applicability one‐pot sequential reactions enables reduction waste resource consumption by eliminating need intermediate purification steps.
Язык: Английский
Процитировано
11
Synthesis, Год журнала: 2023, Номер 55(18), С. 2911 - 2925
Опубликована: Фев. 20, 2023
Abstract This review highlights recent progress in electrochemical cascade cyclization reactions for the synthesis of carbon rings and heterocycles, such as pyridines, quinolines, phenanthridines, cinnolines, 1,4-dihydroquinolines, oxindoles, imidazo[1,5-α]pyridines, imidazoles, etc. The works included herein are introduced two major sections heterocycle construction carbocycle reactions, covering reported from 2012 to 2022. 1 Introduction 2 Electrochemical Cascade Cyclization Synthesis Heterocycles 2.1 Pyridines, Quinolines, Phenanthridines, Cinnolines 2.2 1,4-Dihydroquinolines, Hexacyclic Sulfonamides, Thiazines 2.3 Hydroisoquinolinones Hydroquinolinones 2.4 Quinazolin-4(3H)-ones 2.5 4H-3,1-Benzoxazines 2.6 Oxindoles 2.7 Indolines Indoles 2.8 Imidazo[1,5-α]pyridines Imidazoles 2.9 Imidazolones, Imidazolidinones, Oxazolones, Oxazolidinones 2.10 Benzoxazoles, Oxazolines, Isoxazolines 2.11 Furans Dihydrofurans 2.12 Indolizines, Pyrazoles, Triazolium Inner Salts 2.13 Sulfonated Benzothiophenes, Thiazoles, Dihydrothiazoles, 1,3,4-Thiadiazoles 2.14 Lactones 3 Construction Carbocycles 3.1 Carbon Polycycles Spiroindenes 3.2 Difluoroacyl (Hetero)arenes Indenones 4 Conclusion
Язык: Английский
Процитировано
23
Chemical Communications, Год журнала: 2023, Номер 59(45), С. 6885 - 6888
Опубликована: Янв. 1, 2023
The annulation reactions of enaminones with quinonediimides/quinoneimides for the selective synthesis indoles and 2-aminobenzofurans have been realized. With Zn(II) catalysis, quinonediimides reacted to give via HNMe2-elimination-based aromatization. Fe(III) quinoneimides provided a key dehydrogenative
Язык: Английский
Процитировано
19
Chemical Communications, Год журнала: 2023, Номер 59(30), С. 4467 - 4470
Опубликована: Янв. 1, 2023
The developed methodology describes an environmentally benign protocol for electro-oxidative CF3-radical generation, followed by cascade cyclization fabricating isoxazoline scaffold from a β,γ-unsaturated oxime. Consecutive C-O and C-C bond formations were achieved through this method featuring mild, robust, scalable reaction conditions broad substrate scope. Mechanistic studies revealed the necessity of anodic oxidation process. Further conversion afforded other valuable derivatives.
Язык: Английский
Процитировано
18
Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(3), С. 728 - 728
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
8
Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(15), С. 1727 - 1733
Опубликована: Март 26, 2024
Comprehensive Summary Chemodivergent synthesis of benzofurans and 2,3‐dihydrobenzofurans has been realized. Under a reaction system consisting DBDMH K 2 CO 3 as promotors, controlled conditions enabled the formation two sets valuable heterocycles from tandem transformation enaminones salicylaldehydes. The key to success was identification parameters, in which imine intermediate formed by transient halogenation coupling substitution processes underwent either aldol condensation/annulation or hydrolysis/aldol condensation. additives NH 4 Cl Fe (SO ) unique selectivity this reaction. A broad substrate scope salicylaldehydes employed reaction, demonstrating excellent functional group tolerance versatility.
Язык: Английский
Процитировано
7