Pharmacological Research, Год журнала: 2022, Номер 185, С. 106492 - 106492
Опубликована: Окт. 10, 2022
Язык: Английский
BioMed Research International, Год журнала: 2021, Номер 2021, С. 1 - 15
Опубликована: Сен. 17, 2021
Diabetes mellitus termed as metabolic disorder is a collection of interlinked diseases and mainly body’s inability to manage glucose level which leads cardiovascular diseases, renal failure, neurological disorders, many others. The drugs contemporarily used for diabetes have inevitable side effects, them become less responsive this multifactorial disorder. Momordica charantia commonly known bitter gourd has bioactive compounds with antidiabetic properties. current study was designed use computational methods discover the best peptides devised from hypoglycemic polypeptide-P M. charantia. binding affinity interaction patterns were evaluated against four receptor proteins (i.e., agonists insulin inhibitors sodium-glucose cotransporter 1, dipeptidyl peptidase-IV, transporter 2) using molecular docking approach. A total thirty-seven docked these receptors. Out which, top five each shortlisted based on their S-scores affinities. Finally, eight ligands LIVA, TSEP, EKAI, LKHA, EALF, VAEK, DFGAS, EPGGGG) selected strictly followed Lipinski’s rule exhibited good ADMET profiling. One peptide EPGGGG showed activity towards SGLT1 proteins. complex both targets subjected 50 ns dynamics simulations MM-GBSA energy test that concluded complexes highly stable, intermolecular interactions dominated by van der Waals electrostatic energies. Overall, strongly fulfilled drug-like evaluation criterion proved
Язык: Английский
Процитировано
54
Neuron, Год журнала: 2021, Номер 109(9), С. 1513 - 1526.e11
Опубликована: Март 25, 2021
Язык: Английский
Процитировано
46
Harm Reduction Journal, Год журнала: 2021, Номер 18(1)
Опубликована: Июль 10, 2021
Abstract Background The use of cannabis as medicine (CaM) both prescribed and non-prescribed has increased markedly in the last decade, mirrored a global shift policy towards more permissive stance. There is some evidence that functions substitute for prescription drugs, particularly opioids; however, knowledge needed on motives substitution users, their patterns use, perceived effects use. Aims To explore who substitutes drugs with cannabis, type substituted used, impact drug well terms experienced side effects. Methods A self-selected convenience sample was recruited through social media, public patient organizations to take part an anonymous online survey. Inclusion criteria were 18 years or older (prescribed non-prescribed) medical purpose. Results final included 2.841 respondents which majority (91%) used than half (54.6%) had CaM purpose replacing drug. Compared non-substitution users likely be women treatment chronic pain other somatic conditions. Pain medication (67.2%), antidepressants (24.5%), arthritis (20.7%) most common types replaced CaM. Among 38.1% reported termination 45.9% substantial decrease frequent CBD-oil (65.2%), followed by ‘hash, pot skunk’ (36.6%). More (65.8%) found much effective compared 85.5% associated worse Conclusion frequently opioids. research long-term consequences CaM, including from low high THC products specific mental health
Язык: Английский
Процитировано
43
Molecules, Год журнала: 2023, Номер 28(6), С. 2791 - 2791
Опубликована: Март 20, 2023
Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids are key bioactive compounds with health benefits. The oral consumption of cannabis transports much less hazardous chemicals than smoking. Nevertheless, the response to is biphasically dose-dependent (hormesis; low-dose stimulation high-dose inhibition) wide individuality responses. Thus, exact same dose preparation may be beneficial for some but toxic others. purpose this review highlight concept individual variations cannabinoids, which leads challenge establishing standard safe doses products general population. mechanisms actions, acute chronic toxicities, factors affecting responses updated. Based on literature review, we found that depends exposure (delivery route, duration, frequency, interactions food drugs), (age, sex), susceptibility (genetic polymorphisms cannabinoid receptor gene, N-acylethanolamine-hydrolyzing enzymes, THC-metabolizing epigenetic regulations). Owing responses, safest way use cannabis-containing start low, go slow, stay low.
Язык: Английский
Процитировано
22
Molecules, Год журнала: 2023, Номер 28(9), С. 3849 - 3849
Опубликована: Май 1, 2023
Supercritical carbon dioxide (CO2) extraction techniques meet all-new consumer market demands for health-promoting phytochemical compound-rich extracts produced from green and sustainable technology. In this regard, review is dedicated to discussing the promise of integrating high-pressure CO2 technologies into Cannabis sativa L. processing chain valorize its valuable pharmaceutical properties food biomass. To do this, cannabis plant, cannabinoids, endocannabinoid system were reviewed understand their therapeutic side effects. The supercritical fluid (SFE) technique was presented as a smart alternative producing bioproducts. impact SFE operating conditions on compound examined aerial parts (inflorescences, stems, leaves), seeds, byproducts. Furthermore, opportunities using non-thermal biomass addressed industrial hemp valorization, focusing biorefinery simultaneously produce cannabidiol new ingredients applications plant-based products.
Язык: Английский
Процитировано
20
Journal of Medical Internet Research, Год журнала: 2024, Номер 26, С. e55031 - e55031
Опубликована: Март 9, 2024
The high prevalence of cannabis use among young adults poses substantial global health concerns due to the associated acute and long-term psychosocial risks. Digital modalities, including websites, digital platforms, mobile apps, have emerged as promising tools enhance accessibility availability evidence-based interventions for use. However, existing reviews do not consider specifically, combine cannabis-related outcomes with those many other substances in their meta-analytical results, solely target
Язык: Английский
Процитировано
9
Animal Production Science, Год журнала: 2024, Номер 64(2)
Опубликована: Янв. 12, 2024
Global food insecurity is mostly the result of human-animal competition for food, as well recent population growth, erratic weather patterns and environmental shocks. Therefore, maximising production animal proteins can reduce between demand consumption. Hence, current review aimed at outlining use hemp on production, health reproductive performances farm animals. The data used in this were accessed using Google Scholar, Science Direct, ResearchGate directory open-access journals. It was found that industrial hemp, particularly its derivatives such hemp-seed meal oil, has gained attention potential benefits nutrition health. impact animals, their productivity, performance, an area ongoing research. Our findings assessment nutritional to livestock have shown be a great source because, cake, byproduct oil extraction, rich essential non-essential amino acids, fibre, healthy fats, including omega-3 omega-6 fatty acids. When incorporated into feed, it contribute balanced diet, potentially improving overall productivity. Furthermore, may due acid profile known positive effects reproduction (optimal fertility gestation) health, anti-inflammatory properties, which could benefit conditions related inflammation. Additionally, contains compounds cannabinoids terpenes might offer therapeutic effects, although these animals are still being studied. In conclusion, there limited direct research hemp’s effect performance more necessitated.
Язык: Английский
Процитировано
8
Frontiers in Toxicology, Год журнала: 2025, Номер 6
Опубликована: Янв. 28, 2025
Cannabinoids are part of the most popular group illicit substances in Western world. The word “cannabinoid” refers to any chemical substance, regardless structure or origin, that binds body’s cannabinoid receptors and has effects similar those produced by Cannabis plant. Regarding their cannabinoids can be classified into endocannabinoids, phytocannabinoids synthetic cannabinoids. behavioral physiological have received particular attention over last few decades, including sensations euphoria, relaxation loss concentration, with repeated use being associated short long-term side effects, respiratory cardiovascular disorders, cognitive changes, psychoses, schizophrenia mood disorders. On other hand, recent investigations proposed a promising therapeutic potential cannabinoid-based drugs for wide range medical situations, neurological psychiatric among indications. growing popularity compounds, both recreational purposes, been accompanied an equally continuous evolution knowledge regarding harmful beneficial effects. However, there several open questions challenges answered, which require more better investigations. This article’s main objectives are: i) understand importance action humans; ii) identify different types exist differences action; iii) distinguish legislative framework consumption; iv) possible adverse consumption, as well benefits; v) know existing medical-scientific evidence terms potential, particularly relation aspects safety efficacy; vi) encourage critical thinking about consumption cannabinoids, based on currently available gaps knowledge.
Язык: Английский
Процитировано
1
American Journal of Men s Health, Год журнала: 2019, Номер 13(6)
Опубликована: Дек. 1, 2019
Globally, there is increasing usage and legalization of cannabis. In addition to its reported therapeutic effects, cannabis has several health risks which are not clearly defined. Erectile dysfunction (ED) the most common male sexual disorder plausible mechanisms linking use ED. No attempt been made collate literature on this topic. The aim review was summarize prevalence risk ED in users compared controls. A systematic major databases from inception January 1, 2019, without language restriction, undertaken identify studies investigating presence analysis versus Consequently, odds ratio (OR) with 95% confidence intervals (CI) calculated, applying a random-effect model. Five case–control were included data 3,395 healthy men, 1,035 using (smoking) 2,360 nonusers. overall 69.1% (95% CI: 38.0–89.1), whilst correspondent figure controls 34.7% 20.3–52.7). OR almost four times that (OR = 3.83; 1.30–11.28; p .02), even if characterized by high heterogeneity ( I 2 90%) prediction overlapped 1.00 0.35–7.26). Data suggest twice as Future longitudinal research needed confirm/refute explore dose–response relationship between may be evident.
Язык: Английский
Процитировано
51
Current Opinion in Psychology, Год журнала: 2020, Номер 38, С. 11 - 18
Опубликована: Июнь 20, 2020
Язык: Английский
Процитировано
50