Sex differences in biological aging and the association with clinical measures in older adults

GeroScience, Год журнала: 2023, Номер 46(2), С. 1775 - 1788

Опубликована: Сен. 25, 2023

Abstract Females live longer than males, and there are sex disparities in physical health disease incidence. However, differences biological aging have not been consistently reported may differ depending on the measure used. This study aimed to determine correlations between epigenetic age acceleration (AA), other markers of aging, separately males females. We additionally explored extent which these AA measures differed according socioeconomic characteristics, clinical markers, diseases. Epigenetic clocks (HorvathAge, HannumAge, PhenoAge, GrimAge, GrimAge2, DunedinPACE) were estimated blood from 560 relatively healthy Australians aged ≥ 70 years (females, 50.7%) enrolled ASPREE study. A system-wide deficit accumulation frailty index (FI) composed 67 health-related was generated. Brain subsequently brain-predicted difference (brain-PAD) neuroimaging. had significantly reduced but higher FI, no brain-PAD. FI strongest correlation with DunedinPACE (range r : 0.21 0.24 both sexes). Brain-PAD correlated any measures. Significant sociodemographic characteristics more commonly found females (e.g., for systolic pressure = 0.2, p < 0.001) males. GrimAA Grim2AA associated obesity depression females, while hypertension, diabetes, chronic kidney clocks, as well DunedinPACE. Our findings highlight importance considering when investigating link

Язык: Английский

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Late-Life Metabolic Dysfunction-Associated Steatotic Liver Disease and its Association With Physical Disability and Dementia

The Journals of Gerontology Series A, Год журнала: 2024, Номер 79(4)

Опубликована: Янв. 16, 2024

Abstract Background The burden of metabolic dysfunction-associated steatotic liver disease (MASLD) is growing rapidly, including among older adults. number adults also rising with concomitantly increasing rates age-related physical and cognitive dysfunction. However, data on whether MASLD affects function in limited. As such, we aimed to identify prevalent influences the risk incident disability or dementia initially healthy Methods A post-hoc analysis participants from ASPREE-XT cohort study, which recruited community-dwelling without a history cardiovascular disease, dementia, independence-limiting functional impairment. Fatty Liver Index (to MASLD) was calculated those complete data. Cox proportional-hazards models were used investigate outcomes persistent vs without. Results Of 9 097 individuals included (mean age 75.1 ± 4.2 years; 45.0% men), 341 (3.7%) developed 370 (4.1%) over median follow-up 6.4 years (IQR 5.3–7.5 years). When adjusting for known contributors age, gender, education, comorbidity, measures, associated an increased (HR 1.41 [95% CI: 1.07–1.87]) reduced 0.63 0.48–0.83]). Conclusions Prevalent but relatively Understanding mechanisms underlying these divergent results allow appropriate stratification counseling important.

Язык: Английский

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Neural correlates of frailty in cognitively healthy adults: A multimodal imaging study

PLoS ONE, Год журнала: 2025, Номер 20(3), С. e0320492 - e0320492

Опубликована: Март 26, 2025

Objective Frailty has emerged as prevalent condition in ageing. While frailty been assessed through physical and functional criteria, recent studies have explored the link between cognitive decline frailty, which remains complex warrants further investigation. Our aims were to compare differences at brain level robust frail older people without dementia explore possible associations measures performance with neuropsychological tests. Methods Using data from “CAM-Cam” project that recruited a community dwelling population, we identified participants based on Rockwood index. Magnetic Resonance Imaging was performed probe interplay health. The main were: (i) identify using Cattell Culture Fair test Tip of Tongue (ii) assess voxel-wise group-related effects, general linear model design investigate potential our two study groups (“frail” “robust”). Results findings revealed significantly smaller grey matter volume individuals, primarily localized cerebellar areas right supramarginal gyrus. Diffusion magnetic resonance imaging scans showed diminished axial diffusivity values participants, particularly corticospinal tract. Resting-state MRI increased connectivity within Default Mode Network (DMN) relative group parietal portions DMN. Moreover, observed significant correlations score for groups. Conclusions scores anatomical patterns highlight interconnections aspects frailty. This brings novel insights into early neurobiological markers associated cognitively healthy population.

Язык: Английский

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Contribution of Gait Speed, Grip Strength, and Depression on the Risk of Serious Falls Among Older Adults

Archives of Gerontology and Geriatrics Plus, Год журнала: 2025, Номер unknown, С. 100155 - 100155

Опубликована: Март 1, 2025

Язык: Английский

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Establishing normative pinch and grip strengths across adult age groups in Singapore

BMC Sports Science Medicine and Rehabilitation, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 14, 2025

Pinch and grip strengths are vital indicators of upper limb function, musculoskeletal health, general health. While most research has focused on older individuals, it is crucial to build normative data for younger populations. This cross-sectional study was conducted determine the values lateral pinch strength (LPS) hand (HGS) in healthy adult Singaporeans. The recruited 500 individuals without any serious illnesses pain, aged 21-80 years. LPS HGS were measured using a standardized JAMAR dynamometer. Age, gender, dominance, participant demographics recorded. Normative then established different age groups dominance. A machine learning approach employed relevant variables dominant our data, respectively. Our showed that peaked between 40-44 years women. In men, average 35-39 50-54 Compared non-dominant side, 6.86% 6.23% higher women difference men 6.96% 9.18%, Age strongly associated with participants, but not ones. Height, weight, important predicting LPS, gait speed only. align past results, comparatively lower than consolidated Western norms. hand, significantly higher. No statistical right- left-handed participants terms LPS. results can be valuable researchers healthcare providers working young adults.

Язык: Английский

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Physical function is associated with cognitive status, brain amyloid‐beta deposition, and blood biomarkers in Chinese Han population

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(8)

Опубликована: Авг. 1, 2024

Abstract Background The physical function of elderly individuals reflects whether they have had a history regular activity over the long term. Such indicators been found to certain connection with cognitive these years. However, there is limited research that associates it mechanisms such as cerebral Aβ deposition. We aim investigate this relationship and unveil underlying mechanisms. Method Physical cognition data 4189 participants were obtained from Chinese preclinical Alzheimer's disease study. Participants divided into six groups according severity. Among them, 1048 underwent positron emission tomography‐computed tomography (PET‐CT) plasma biomarker test. Grip strength gait combined score indicating function. Multiple linear regression models logistic mainly used conduct analysis. Results There was significant positive correlation between ( R = 0.48, p < 0.001), independent sex, age, apolipoprotein E‐ε4 genotype, stages 0.001). effective in distinguishing impairment those without (AUC 0.835). negatively associated brain deposition 0.008) an intermediary effect 0.01) on association women. This evident lateral parietal, temporal, posterior cingulate, frontal, occipital, precuneus regions. neurofilament light‐chain (Nfl) level Conclusions strongly elderly, partly mediates linkage Plasma Nfl can be potential target for exercise intervention Improving will contribute alleviation decline.

Язык: Английский

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Validation of newly derived polygenic risk scores for dementia in a prospective study of older individuals

Alzheimer s & Dementia, Год журнала: 2023, Номер 19(12), С. 5333 - 5342

Опубликована: Май 12, 2023

Abstract INTRODUCTION Recent genome‐wide association studies identified new dementia‐associated variants. We assessed the performance of updated polygenic risk scores (PRSs) using these variants in an independent cohort. METHODS used Cox models and area under curve (AUC) to validate PRSs (PRS‐83SNP, PRS‐SBayesR, PRS‐CS) compared with older PRS‐23SNP 12,031 initially‐healthy participants ≥70 years age. Dementia was rigorously adjudicated according Diagnostic Statistical Manual Mental Disorders, Fourth Edition (DSM‐IV) criteria. RESULTS PRS‐83SNP, PRS‐CS were associated incident dementia, fully adjusted (including apolipoprotein E [ APOE ] ε4) hazard ratios per standard deviation (SD) 1.35 (1.23–1.47), 1.37 (1.25–1.50), 1.42 (1.30–1.56), respectively. The AUC a model containing conventional/non‐genetic factors 74.7%. This improved 75.7% ( p = 0.007), 76% 0.004), 76.1% 0.003) addition PRS‐CS, did not improve (74.7%, 0.95). CONCLUSION New for dementia significantly risk‐prediction performance, but still account less than genotype overall.

Язык: Английский

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Gait speed, handgrip strength, and their combination, and risk of depression in later life: Evidence from a prospective study of community-dwelling older adults

Journal of Affective Disorders, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Relative handgrip strength as a vitality measure in US stroke survivors

Disability and Rehabilitation, Год журнала: 2024, Номер unknown, С. 1 - 7

Опубликована: Март 12, 2024

Purpose Stroke is a leading cause of long-term disability in the US, yet feasible assessment measure with predictive value for components International Classification Functioning, Disability, and Health (ICF) Core Set lacking. The purpose present study was to explore potential measures on factors within each ICF component stroke survivors.

Язык: Английский

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Associations of body habitus and its changes with incident dementia in older adults

Journal of the American Geriatrics Society, Год журнала: 2024, Номер 72(4), С. 1023 - 1034

Опубликована: Янв. 19, 2024

Abstract Background This study examined the associations of body mass index (BMI) and waist circumference (WC), as well their short‐ long‐term changes over time, with incident dementia in older individuals. Methods Data came from 18,837 community‐dwelling individuals aged 65+ years Australia United States, who were relatively healthy without major cognitive impairment at enrolment. Anthropometric measures prospectively assessed baseline, change variability baseline to year two (three time‐points). In a subgroup ( n = 11,176), self‐reported weight age 18 70+ was investigated. Dementia cases satisfied DSM‐IV criteria. Cox regression used examine between anthropometric risk dementia. Results Compared normal weight, an overweight (HR: 0.67, 95%CI: 0.57–0.79, p < 0.001) or obese BMI 0.73, 0.60–0.89, 0.002), larger WC (elevated, HR: 0.71, 0.58–0.86, 0.001; highly elevated, 0.65, 0.55–0.78, relative low) associated lower risk. contrast, substantial increases (>5%) 2 after higher 1.49, 95% CI: 1.17–1.91, 0.001). Increased also seen underweight 2‐year decrease (>5%), but these appeared only first 4 follow‐up. both years, being times increased 2.27, 1.22–4.24, 0.01), while obesity decreased 0.70, 0.51–0.95, 0.02). Conclusions Our findings suggest that gain later life may be factors for Being having loss old early markers pre‐clinical

Язык: Английский

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