Environmental Research, Год журнала: 2024, Номер 264, С. 120351 - 120351
Опубликована: Ноя. 12, 2024
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(25)
Опубликована: Март 29, 2024
Abstract Viscous biofluids on wounds challenge conventional “water‐absorbing” wound dressings in efficient drainage due to their poor fluidity, generally causing prolonged inflammation, anti‐angiogenesis, and delayed closure. Herein, it is reported that a self‐pumping organohydrogel dressing (SPD) with aligned hydrated hydrogel channels, prepared by three‐dimensional‐templated wetting‐enabled‐transfer (3D‐WET) polymerization process, can efficiently drain viscous fluids accelerate diabetic healing. The asymmetric wettability of the hydrophobic–hydrophilic layers channels enable unidirectional away from wounds, preventing overhydration inflammatory stimulation. organogel layer adhere onto skin around but be easily detached wet area, avoiding secondary trauma newly formed tissues. Taking rat model as an example, SPD significantly downregulate inflammation response ≈70.8%, enhance dermal remodeling ≈14.3%, shorten closure time about 1/3 compared commercial (3M, Tegaderm hydrocolloid thin dressing). This study sheds light development next generation functional for chronic involving biofluids.
Язык: Английский
Процитировано
43
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6610 - 6610
Опубликована: Июнь 15, 2024
Skin is the largest organ in human body and requires proper dressing to facilitate healing after an injury. Wounds on movable parts, such as elbow, knee, wrist, neck, usually undergo delayed inefficient due frequent movements. To better accommodate wounds, a variety of functional hydrogels have been successfully developed used flexible wound dressings. On one hand, mechanical properties, adhesion, stretchability, self-healing, make these suitable for mobile wounds promote process; other bioactivities, antibacterial antioxidant performance, could further accelerate process. In this review, we focus recent advances hydrogel-based dressings propose challenges perspectives
Язык: Английский
Процитировано
19
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101595 - 101595
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
5
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
3
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(3)
Опубликована: Май 1, 2024
Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease
Язык: Английский
Процитировано
14
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 8, 2024
Abstract Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) inflammatory factors levels the lung. Multiple evidences suggest that nanozyme with diversified catalytic capabilities plays vital role this fatal injury. At present, we developed novel class of polydopamine (PDA) coated cerium dioxide (CeO 2 ) (Ce@P) acts as potent ROS scavenger for scavenging intracellular suppressing responses against ALI. Herein, aimed to identify Ce@P combining NIR irradiation could further strengthen its capacity. Specifically, triggered exhibited most antioxidant anti-inflammatory behaviors lipopolysaccharide (LPS) induced macrophages through decreasing levels, down-regulating TNF-α, IL-1β IL-6, up-regulating level cytokine (SOD-2), inducing M2 directional polarization (CD206 up-regulation), increasing expression HSP70. Besides, performed intravenous (IV) injection LPS ALI rat model, found it significantly accumulated tissue 6 h after injection. It was also observed + presented superior inflammation, alleviating diffuse alveolar damage, well promoting repair. All all, has strategy using synergistic enhanced treatment ALI, which can serve promising therapeutic clinical derived diseases well.
Язык: Английский
Процитировано
12
Journal of Zhejiang University SCIENCE B, Год журнала: 2024, Номер 25(5), С. 361 - 388
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
11
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
Abstract Diabetic foot ulcer typically undergoes a delayed wound‐healing process owing to the disordered microenvironment, including persistent inflammation, long‐term hypoxia, and excessive fibrosis, eventually leading severe disabilities other poor outcomes. However, current strategies cannot meet dynamic demands during process. Herein, reactive oxygen species (ROS)–responsive oxygen‐generating microneedle platform, consisting of sericin‐based glucose‐responsive hydrogel loaded with verteporfin, for effective diabetic wound healing is proposed. Under highly oxidative functionalized sericin protein depletes overproduced ROS generate oxygen, which can not only alleviate hypoxic microenvironment promote angiogenesis by activating extracellular signal‐regulated kinase Heme Oxygenase‐1 pathways but also decrease expression proinflammatory cytokines. Moreover, hyperglycaemic condition triggers gradual dissociation this platform promotes release verteporfin enhance scarless re‐epithelization via inhibiting yes‐associated signal. This versatile system integrates advantageous features inflammation alleviation, promotion, scar inhibition capabilities, accelerates repair in vivo, offers novel approach self‐supply remodeling.
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140797 - 140797
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
2
Small, Год журнала: 2025, Номер unknown
Опубликована: Фев. 16, 2025
The management of abscess wounds induced by antibiotic-resistant bacterial infections has become increasingly formidable due to the widespread overutilization and misuse antimicrobial agents. This study presents an innovative dissolvable microneedle (MN) patch incorporating Au@ZnO/Ce nanocomposites vancomycin (AZC/Van@MN), exhibiting robust anti-inflammatory properties, meticulously engineered for therapeutic intervention wounds. developed AZC/Van@MN demonstrates exceptional biocompatibility as evidenced comprehensive histopathological hematological assessments. It effectively eradicates colonies through synergistic action Van mild photothermal therapy (PTT, ≤42 °C). Transcriptomic analysis elucidates that antibacterial mechanism involves upregulation riboflavin biosynthesis suppression arginine pathways. Furthermore, significantly reduces dimensions, load, inflammatory response, while simultaneously enhancing wound healing via accelerated re-epithelialization angiogenesis. double-edged MN represents a promising strategy combating skin abscesses instigated bacteria.
Язык: Английский
Процитировано
1