Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 29, 2024
Abstract
Viscous
biofluids
on
wounds
challenge
conventional
“water‐absorbing”
wound
dressings
in
efficient
drainage
due
to
their
poor
fluidity,
generally
causing
prolonged
inflammation,
anti‐angiogenesis,
and
delayed
closure.
Herein,
it
is
reported
that
a
self‐pumping
organohydrogel
dressing
(SPD)
with
aligned
hydrated
hydrogel
channels,
prepared
by
three‐dimensional‐templated
wetting‐enabled‐transfer
(3D‐WET)
polymerization
process,
can
efficiently
drain
viscous
fluids
accelerate
diabetic
healing.
The
asymmetric
wettability
of
the
hydrophobic–hydrophilic
layers
channels
enable
unidirectional
away
from
wounds,
preventing
overhydration
inflammatory
stimulation.
organogel
layer
adhere
onto
skin
around
but
be
easily
detached
wet
area,
avoiding
secondary
trauma
newly
formed
tissues.
Taking
rat
model
as
an
example,
SPD
significantly
downregulate
inflammation
response
≈70.8%,
enhance
dermal
remodeling
≈14.3%,
shorten
closure
time
about
1/3
compared
commercial
(3M,
Tegaderm
hydrocolloid
thin
dressing).
This
study
sheds
light
development
next
generation
functional
for
chronic
involving
biofluids.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6610 - 6610
Published: June 15, 2024
Skin
is
the
largest
organ
in
human
body
and
requires
proper
dressing
to
facilitate
healing
after
an
injury.
Wounds
on
movable
parts,
such
as
elbow,
knee,
wrist,
neck,
usually
undergo
delayed
inefficient
due
frequent
movements.
To
better
accommodate
wounds,
a
variety
of
functional
hydrogels
have
been
successfully
developed
used
flexible
wound
dressings.
On
one
hand,
mechanical
properties,
adhesion,
stretchability,
self-healing,
make
these
suitable
for
mobile
wounds
promote
process;
other
bioactivities,
antibacterial
antioxidant
performance,
could
further
accelerate
process.
In
this
review,
we
focus
recent
advances
hydrogel-based
dressings
propose
challenges
perspectives
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(3)
Published: May 1, 2024
Abstract
The
misuse
of
antibiotics
has
led
to
increased
bacterial
resistance,
posing
a
global
public
health
crisis
and
seriously
endangering
lives.
Currently,
antibiotic
therapy
remains
the
most
common
approach
for
treating
infections,
but
its
effectiveness
against
multidrug‐resistant
bacteria
is
diminishing
due
slow
development
new
increase
drug
resistance.
Consequently,
developing
a\ntimicrobial
strategies
improving
efficacy
combat
infection
become
an
urgent
priority.
emergence
nanotechnology
revolutionized
traditional
treatment,
presenting
opportunities
refractory
infection.
Here
we
comprehensively
review
research
progress
in
nanotechnology‐based
antimicrobial
delivery
highlight
diverse
platforms
designed
target
different
resistance
mechanisms.
We
also
outline
use
combining
with
other
therapeutic
modalities
enhance
drug‐resistant
infections.
These
innovative
have
potential
susceptibility
overcome
Finally,
challenges
prospects
application
nanomaterial‐based
combating
are
discussed.
This
article
categorized
under:
Biology‐Inspired
Nanomaterials
>
Nucleic
Acid‐Based
Structures
Therapeutic
Approaches
Drug
Discovery
Nanomedicine
Infectious
Disease
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 8, 2024
Abstract
Acute
lung
injury
(ALI)
is
a
life
threatening
disease
in
critically
ill
patients,
and
characterized
by
excessive
reactive
oxygen
species
(ROS)
inflammatory
factors
levels
the
lung.
Multiple
evidences
suggest
that
nanozyme
with
diversified
catalytic
capabilities
plays
vital
role
this
fatal
injury.
At
present,
we
developed
novel
class
of
polydopamine
(PDA)
coated
cerium
dioxide
(CeO
2
)
(Ce@P)
acts
as
potent
ROS
scavenger
for
scavenging
intracellular
suppressing
responses
against
ALI.
Herein,
aimed
to
identify
Ce@P
combining
NIR
irradiation
could
further
strengthen
its
capacity.
Specifically,
triggered
exhibited
most
antioxidant
anti-inflammatory
behaviors
lipopolysaccharide
(LPS)
induced
macrophages
through
decreasing
levels,
down-regulating
TNF-α,
IL-1β
IL-6,
up-regulating
level
cytokine
(SOD-2),
inducing
M2
directional
polarization
(CD206
up-regulation),
increasing
expression
HSP70.
Besides,
performed
intravenous
(IV)
injection
LPS
ALI
rat
model,
found
it
significantly
accumulated
tissue
6
h
after
injection.
It
was
also
observed
+
presented
superior
inflammation,
alleviating
diffuse
alveolar
damage,
well
promoting
repair.
All
all,
has
strategy
using
synergistic
enhanced
treatment
ALI,
which
can
serve
promising
therapeutic
clinical
derived
diseases
well.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Diabetic
foot
ulcer
typically
undergoes
a
delayed
wound‐healing
process
owing
to
the
disordered
microenvironment,
including
persistent
inflammation,
long‐term
hypoxia,
and
excessive
fibrosis,
eventually
leading
severe
disabilities
other
poor
outcomes.
However,
current
strategies
cannot
meet
dynamic
demands
during
process.
Herein,
reactive
oxygen
species
(ROS)–responsive
oxygen‐generating
microneedle
platform,
consisting
of
sericin‐based
glucose‐responsive
hydrogel
loaded
with
verteporfin,
for
effective
diabetic
wound
healing
is
proposed.
Under
highly
oxidative
functionalized
sericin
protein
depletes
overproduced
ROS
generate
oxygen,
which
can
not
only
alleviate
hypoxic
microenvironment
promote
angiogenesis
by
activating
extracellular
signal‐regulated
kinase
Heme
Oxygenase‐1
pathways
but
also
decrease
expression
proinflammatory
cytokines.
Moreover,
hyperglycaemic
condition
triggers
gradual
dissociation
this
platform
promotes
release
verteporfin
enhance
scarless
re‐epithelization
via
inhibiting
yes‐associated
signal.
This
versatile
system
integrates
advantageous
features
inflammation
alleviation,
promotion,
scar
inhibition
capabilities,
accelerates
repair
in
vivo,
offers
novel
approach
self‐supply
remodeling.
