Multifunctional carboxymethyl chitosan/oxidized carboxymethyl cellulose hydrogel loaded with ginsenoside Rg1 and polydopamine nanoparticles for infected diabetic wound healing DOI
Sihui Li, Xiaofeng Ren, Youbo Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136686 - 136686

Published: Oct. 1, 2024

Language: Английский

A Viscous‐Biofluid Self‐Pumping Organohydrogel Dressing to Accelerate Diabetic Wound Healing DOI

Wuyi Xiao,

Xizi Wan,

Lianxin Shi

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 29, 2024

Abstract Viscous biofluids on wounds challenge conventional “water‐absorbing” wound dressings in efficient drainage due to their poor fluidity, generally causing prolonged inflammation, anti‐angiogenesis, and delayed closure. Herein, it is reported that a self‐pumping organohydrogel dressing (SPD) with aligned hydrated hydrogel channels, prepared by three‐dimensional‐templated wetting‐enabled‐transfer (3D‐WET) polymerization process, can efficiently drain viscous fluids accelerate diabetic healing. The asymmetric wettability of the hydrophobic–hydrophilic layers channels enable unidirectional away from wounds, preventing overhydration inflammatory stimulation. organogel layer adhere onto skin around but be easily detached wet area, avoiding secondary trauma newly formed tissues. Taking rat model as an example, SPD significantly downregulate inflammation response ≈70.8%, enhance dermal remodeling ≈14.3%, shorten closure time about 1/3 compared commercial (3M, Tegaderm hydrocolloid thin dressing). This study sheds light development next generation functional for chronic involving biofluids.

Language: Английский

Citations

44

Hydrogel Wound Dressings Accelerating Healing Process of Wounds in Movable Parts DOI Open Access
Pengcheng Yu, Liqi Wei, Zhiqi Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6610 - 6610

Published: June 15, 2024

Skin is the largest organ in human body and requires proper dressing to facilitate healing after an injury. Wounds on movable parts, such as elbow, knee, wrist, neck, usually undergo delayed inefficient due frequent movements. To better accommodate wounds, a variety of functional hydrogels have been successfully developed used flexible wound dressings. On one hand, mechanical properties, adhesion, stretchability, self-healing, make these suitable for mobile wounds promote process; other bioactivities, antibacterial antioxidant performance, could further accelerate process. In this review, we focus recent advances hydrogel-based dressings propose challenges perspectives

Language: Английский

Citations

21

Cell Membrane-derived Nanovesicles as Extracellular Vesicle-mimetics in Wound Healing DOI Creative Commons
Wen Li, Huihui Zhang, Lianglong Chen

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101595 - 101595

Published: Feb. 19, 2025

Language: Английский

Citations

6

Hyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers DOI
Xiaoliang Qi, Ying Li,

Yajing Xiang

et al.

Published: March 1, 2025

Language: Английский

Citations

3

Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections DOI
Junjie Zhang,

Ming Liu,

Haiyang Guo

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease

Language: Английский

Citations

14

NIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging DOI Creative Commons
Mingjing Yin,

Doudou Lei,

Yalan Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 8, 2024

Abstract Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) inflammatory factors levels the lung. Multiple evidences suggest that nanozyme with diversified catalytic capabilities plays vital role this fatal injury. At present, we developed novel class of polydopamine (PDA) coated cerium dioxide (CeO 2 ) (Ce@P) acts as potent ROS scavenger for scavenging intracellular suppressing responses against ALI. Herein, aimed to identify Ce@P combining NIR irradiation could further strengthen its capacity. Specifically, triggered exhibited most antioxidant anti-inflammatory behaviors lipopolysaccharide (LPS) induced macrophages through decreasing levels, down-regulating TNF-α, IL-1β IL-6, up-regulating level cytokine (SOD-2), inducing M2 directional polarization (CD206 up-regulation), increasing expression HSP70. Besides, performed intravenous (IV) injection LPS ALI rat model, found it significantly accumulated tissue 6 h after injection. It was also observed + presented superior inflammation, alleviating diffuse alveolar damage, well promoting repair. All all, has strategy using synergistic enhanced treatment ALI, which can serve promising therapeutic clinical derived diseases well.

Language: Английский

Citations

12

二氧化铈纳米颗粒: 生物医学应用和毒性 DOI

Xiaoxuan Fu,

Peng Li, Xi Chen

et al.

Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: 25(5), P. 361 - 388

Published: May 1, 2024

Language: Английский

Citations

11

Silk Sericin‐based ROS‐Responsive Oxygen Generating Microneedle Platform Promotes Angiogenesis and Decreases Inflammation for Scarless Diabetic Wound Healing DOI
Huan Liu,

Sumei Qin,

Hongyan Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Abstract Diabetic foot ulcer typically undergoes a delayed wound‐healing process owing to the disordered microenvironment, including persistent inflammation, long‐term hypoxia, and excessive fibrosis, eventually leading severe disabilities other poor outcomes. However, current strategies cannot meet dynamic demands during process. Herein, reactive oxygen species (ROS)–responsive oxygen‐generating microneedle platform, consisting of sericin‐based glucose‐responsive hydrogel loaded with verteporfin, for effective diabetic wound healing is proposed. Under highly oxidative functionalized sericin protein depletes overproduced ROS generate oxygen, which can not only alleviate hypoxic microenvironment promote angiogenesis by activating extracellular signal‐regulated kinase Heme Oxygenase‐1 pathways but also decrease expression proinflammatory cytokines. Moreover, hyperglycaemic condition triggers gradual dissociation this platform promotes release verteporfin enhance scarless re‐epithelization via inhibiting yes‐associated signal. This versatile system integrates advantageous features inflammation alleviation, promotion, scar inhibition capabilities, accelerates repair in vivo, offers novel approach self‐supply remodeling.

Language: Английский

Citations

10

Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing DOI
Chenguang Liu,

Ronger Ai,

Bi-zhi Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140797 - 140797

Published: Feb. 7, 2025

Language: Английский

Citations

2

Double‐Edged Dissolving Microneedle Patches Loaded with Zn/Ce Composites and Vancomycin for Treatment of Drug‐Resistant Bacterial Infected Skin Abscess DOI Open Access

Yu Jin,

Zhaoyou Chu, Pengfei Zhu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

The management of abscess wounds induced by antibiotic-resistant bacterial infections has become increasingly formidable due to the widespread overutilization and misuse antimicrobial agents. This study presents an innovative dissolvable microneedle (MN) patch incorporating Au@ZnO/Ce nanocomposites vancomycin (AZC/Van@MN), exhibiting robust anti-inflammatory properties, meticulously engineered for therapeutic intervention wounds. developed AZC/Van@MN demonstrates exceptional biocompatibility as evidenced comprehensive histopathological hematological assessments. It effectively eradicates colonies through synergistic action Van mild photothermal therapy (PTT, ≤42 °C). Transcriptomic analysis elucidates that antibacterial mechanism involves upregulation riboflavin biosynthesis suppression arginine pathways. Furthermore, significantly reduces dimensions, load, inflammatory response, while simultaneously enhancing wound healing via accelerated re-epithelialization angiogenesis. double-edged MN represents a promising strategy combating skin abscesses instigated bacteria.

Language: Английский

Citations

2