Food Chemistry, Год журнала: 2023, Номер 429, С. 136900 - 136900
Опубликована: Июль 17, 2023
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(15), С. 2550 - 2550
Опубликована: Авг. 3, 2024
Polyphenols are natural compounds which plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols mostly found fruits vegetables. Currently, many diseases waiting for a cure or solution to reduce their symptoms. However, drug other chemical strategies limitations using treatment agent still detection tool diseases, thus researchers need investigate preventive improving treatment. Therefore, it is elucidate polyphenols, bioactivity effects, supplementation, consumption. The disadvantage that they limited bioavailability, although beneficial outcomes with roles. In this context, several different developed improve particularly liposomal nanoparticles. As nutrition one most important factors health, inclusion molecules daily diet significant continues be enthusiastically researched. Nutrition, individuals all ages, key polyphenols.
Язык: Английский
Процитировано
21
Nutrients, Год журнала: 2025, Номер 17(2), С. 275 - 275
Опубликована: Янв. 13, 2025
Type 2 diabetes mellitus (T2DM), a serious metabolic disorder, is worldwide health problem due to the alarming rise in prevalence and elevated morbidity mortality. Chronic hyperglycemia, insulin resistance, ineffective effect secretion are hallmarks of T2DM, leading many secondary complications. These include, particular, cardiovascular disorders, diabetic neuropathy, nephropathy retinopathy, foot, osteoporosis, liver damage, susceptibility infections some cancers. Polyphenols such as flavonoids, phenolic acids, stilbenes, tannins, lignans constitute an extensive heterogeneous group phytochemicals fresh fruits, vegetables their products. Various vitro studies, animal model studies available clinical trials revealed that flavonoids (e.g., quercetin, kaempferol, rutin, epicatechin, genistein, daidzein, anthocyanins), acids chlorogenic, caffeic, ellagic, gallic curcumin), stilbenes resveratrol), tannins procyanidin B2, seaweed phlorotannins), pinoresinol) have ability lower enhance sensitivity improve secretion, scavenge reactive oxygen species, reduce chronic inflammation, modulate gut microbiota, alleviate complications T2DM. The interaction between polyphenols conventional antidiabetic drugs offers promising strategy management treatment especially advanced disease stages. Synergistic effects with been documented, but also antagonistic interactions may impair drug efficacy. Therefore, additional research required clarify mutual order use knowledge applications. Nevertheless, dietary can be successfully applied part supportive for they both obvious symptoms
Язык: Английский
Процитировано
4
Journal of Agriculture and Food Research, Год журнала: 2025, Номер unknown, С. 101641 - 101641
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
4
Antioxidants, Год журнала: 2025, Номер 14(2), С. 200 - 200
Опубликована: Фев. 10, 2025
Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, extending shelf life. The effectiveness of PPs has different molecular biological reasons, predominantly linked to their hydroxyl groups electron delocalization, which interact with microbial cell membranes, proteins, organelles. These interactions may reduce the efficiency metabolic pathways, cause destructive damage membrane, or they harm proteins nucleic acids foodborne bacteria. Moreover, exhibit distinctive ability form complexes metal ions, further amplifying activity. This narrative review explores complex multifaceted between pathogens, underlying correlation chemical structures mechanisms action. Such insights shed light on potential innovative natural preservatives within systems, presenting an eco-friendly sustainable alternative synthetic additives.
Язык: Английский
Процитировано
3
Phytochemistry Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
2
Trends in Food Science & Technology, Год журнала: 2021, Номер 111, С. 114 - 127
Опубликована: Март 5, 2021
Procyanidins, commonly found in plant natural sources, are polymerized forms of flavanols, which a subclass flavonoids. They have been reported to exhibit broad benefits human health and used the prevention cancers, cardiovascular diseases, diabetes, etc. Bioactivities procyanidins depend on many factors including structures procyanidins. Differences composition monomers degree polymerization (DP) contribute variation The basic sources summarized detail. Importantly, structure-activity relationships procyanidins, especially relationship between degrees their antioxidant, anticancer, antidiabetic, anti-obesity, cardioprotective effects as well potential mechanisms reviewed Additionally, current challenges studies discussed. Procyanidins structurally diverse compounds can be classified monomeric, oligomeric, or polymeric variants depending DP, plays role manifesting various that associated with health. diversity complexity these chemical difficulties encountered isolation continue major challenges. A better understanding this information may promote use improving
Язык: Английский
Процитировано
86
Food Chemistry, Год журнала: 2021, Номер 371, С. 131106 - 131106
Опубликована: Сен. 9, 2021
Язык: Английский
Процитировано
73
Molecules, Год журнала: 2021, Номер 26(14), С. 4333 - 4333
Опубликована: Июль 17, 2021
Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous challenging. Over past decades, there has an increasing body of literature related to effects secondary metabolites from botanical sources on diabetes. Plants-derived including alkaloids, phenols, anthocyanins, flavonoids, stilbenoids, saponins, tannins, polysaccharides, coumarins, terpenes can target cellular molecular mechanisms involved carbohydrate metabolism. In addition, they grant protection pancreatic beta cells damage, repairing abnormal insulin signaling, minimizing oxidative stress inflammation, activating AMP-activated protein kinase (AMPK), inhibiting digestion absorption. Studies highlighted many bioactive naturally occurring plants’ as candidates against This review summarizes current knowledge compiled latest studies published during decade mechanism-based action plants-derived that various metabolic pathways humans It worth mentioning data this will provide a guide researchers field, develop into environment-friendly effective, yet safe antidiabetics.
Язык: Английский
Процитировано
70
Trends in Food Science & Technology, Год журнала: 2021, Номер 111, С. 12 - 26
Опубликована: Фев. 21, 2021
Язык: Английский
Процитировано
68
Heliyon, Год журнала: 2022, Номер 9(1), С. e12698 - e12698
Опубликована: Дек. 31, 2022
Healthy diet is vital to cellular health. The human body succumbs numerous diseases which afflict severe economic and psychological burdens on the patient family. Oxidative stress a possible crucial regulator of various pathologies, including type 2 diabetes neurodegenerative diseases. It generates reactive oxygen species (ROS) that trigger dysregulation essential functions, ultimately affecting health homeostasis. However, lower levels ROS can be advantageous are implicated in variety signaling pathways. Due this dichotomy, terms oxidative "eustress," refers good event, "distress," hazardous, have developed. affects multiple pathways, leading compromised insulin secretion, resistance, β-cell dysfunction diabetes. also associated with increased mitochondrial neuroinflammation, aggravating conditions body, particularly age. Treatment includes drugs/therapies often dependence, side effects non-selectivity, toxicity, long run. imperative explore alternative medicines as an adjunct therapy, utilizing natural remedies/resources avoid all harms. Antioxidants components our fight disease by reducing or nullifying excess toxic free radicals produced under pathological conditions. In review, we focus antioxidant dietary foods such tea, coffee, wine, oils, honey role mechanism action these antioxidants alleviating disorders. We aim provide information about alternatives drug treatments used alone combined reduce intake encourage consumption ingredients at doses adequate promote combat pathologies while unwanted risks effects.
Язык: Английский
Процитировано
44