Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Март 1, 2024

Non-alcoholic fatty liver disease (NAFLD) is a common chronic with an increasing incidence worldwide. Single drug therapy may have toxic side effects and disrupt gut microbiota balance. Polyphenols are widely used in intervention due to their distinctive nutritional properties medicinal value, which potential modulator. However, there lack of comprehensive review explore the efficacy mechanism combined drugs polyphenols for NAFLD. Based on this, this firstly discusses link between NAFLD microbiota, outlines microbiota. Secondly, it examined recent advances treatment therapeutic effect combination two. Finally, we highlight underlying mechanisms polyphenol This mainly terms signaling pathways (NF-κB, AMPK, Nrf2, JAK/STAT, PPAR, SREBP-1c, PI3K/Akt TLR) Furthermore, some emerging such as microRNA biomarker therapies provide avenues Drawing inspiration from strategies, use active substances holds transformative prospective potential, both improve restore balance while reducing required dosage. systematically bidirectional interactions NAFLD, summarizes synergistic by modulating Future researches should develop multi-omics technology identify patients who benefit devising individualized plans enhance its effect.

Язык: Английский

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Natural polyphenols-gut microbiota interactions and effects on glycolipid metabolism via polyphenols-gut-brain axis: A state-of-the-art review

Trends in Food Science & Technology, Год журнала: 2023, Номер 140, С. 104171 - 104171

Опубликована: Сен. 12, 2023

Язык: Английский

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Tea Polyphenols Reduced Obesity by Modulating Gut Microbiota‐SCFAs‐Barrier and Inflammation in High‐Fat Diet‐Induced Mice

Molecular Nutrition & Food Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Scope Obesity by high‐fat diets (HFDs) is a chronic metabolic disorder that poses significant threat to human health. Tea polyphenols (TPs) can prevent obesity caused HFD modulating gut microbiota. Methods and results To explore the function of TP in mitigating effects inflammation, mice are fed HFDs either with or without TP. supplementation effectively attenuates HFD‐induced weight gain, liver adipose tissue accumulation, while also improving fat content as well colon ileum morphology. leads downregulation lipid accumulation genes an upregulation lipid‐decomposition genes. Moreover, increases Blautia Faecalibaculum reducing Colidextribacter short‐chain fatty acids mice, significantly activates G protein‐coupled receptors, inhibits histone deacetylases, enhances intestinal tight junction expression levels, reduces permeability, thereby preserves barrier integrity. Additionally, markedly suppresses inflammatory cytokines activation TLR4 signaling pathways. Conclusion These findings suggest holds great promise for both management alleviating provides clue understanding antiobesity

Язык: Английский

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Simultaneous binding of quercetin and catechin to FOXO3 enhances IKKα transcription inhibition and suppression of oxidative stress-induced acute alcoholic liver injury in rats

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Oxidative stress is one of the major contributors to acute alcoholic liver injury (AALI), which a common disease. Quercetin and catechin are flavonoid antioxidants present in plant foods possess chemopreventive chemotherapeutic activities. often included same meal ingested together. While they show cooperative actions against oxidative damage, underlying mechanisms behind their counteracting effects stress-induced AALI remain poorly understood. The aim this study was understand mechanism enhanced antioxidant effect quercetin-catechin combination alleviate rats. ethanol (EtOH)-treated rats H2O2-treated cells were used demonstrate quercetin catechin. Then we RNA-sequencing compare alone, alone then identified critical role IKKα combining with gene silencing overexpression techniques. Its transcription factor, FOXO3 found through yeast one-hybrid assay, luciferase reporter EMSA ChIP assay. Finally, interaction between quercetin, verified molecular docking, UV–Vis absorption spectroscopy, fluorescence CD spectroscopy. demonstrated EtOH-treated cells. cooperatively inhibited IKKα/p53 pathway activated Nrf2 signaling pathway. negative regulator joint action. bound promoter regulate transcription. influenced FOXO3-IKKα binding attaching directly at different sites altering FOXO3′s secondary structures. Our revealed jointly interacting factor. This research opens new vistas for examining therapeutics towards functional proteins confirms multiple flavonoids via co-regulation.

Язык: Английский

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Research progress of electrospinning in food field: A review

Food Hydrocolloids, Год журнала: 2024, Номер 158, С. 110474 - 110474

Опубликована: Июль 29, 2024

Язык: Английский

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A comprehensive review on the promising purple leaf tea

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2025, Номер 24(2)

Опубликована: Март 1, 2025

Purple leaf tea products (PTPs) are processed from purple leaves (PTLs) and combine unique color, flavors, superior health benefits, holding promising market potential. However, PTLs contain chemical compositions, the lack of systematic generalization PTPs processing techniques has led to under-representation their qualities. Compared traditional green products, knowledge about is extremely limited lacks a framework linking composition, techniques, which largely exploitation PTPs. This review summarizes composition PTLs, highlights variations across effects on flavor qualities It also explores potential benefits examines challenges incorporating into food industry, offering insights applications. The characterized by its polyphenolic profile, rich in anthocyanins, catechins, O-methyl aroma components such as α/β-ionone linalool. requires suitable methods maximize health-promoting effects. offer notable including antioxidant, anti-inflammatory, anticancer, neuroprotective, anti-obesity effects, primarily due components. Additionally, show great natural colorants applications dietary supplements tea-flavored beverages. Based these overviews, key possible future research directions outlined, especially advancing production systematically evaluating expanding

Язык: Английский

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Research on the effects of intestinal FXR agonists and antibiotics on the regulation of red kidney bean polysaccharides in the liver metabolism in mice with type 2 diabetes

eFood, Год журнала: 2024, Номер 5(3)

Опубликована: Май 24, 2024

Abstract Our previous study revealed that red kidney bean polysaccharides (RKB) exhibit a pronounced hypoglycemic effect on type 2 diabetic rats, while simultaneously exerting significant ameliorative impact hepatic damage in these animals. However, the precise mechanism underlying effects of RKB diabetes and liver metabolism remains unproven. In this study, we utilized mouse model induced by high‐fat diet combined with streptozotocin to investigate RKB. We administered intervention involving antibiotics, fexaramine, elucidate RKB's effects. findings demonstrated significantly ameliorated function indices histopathological injuries. Nevertheless, when antibiotics fexaramine were introduced as interventions, they hindered beneficial mice. Furthermore, our nontargeted metabolomics analysis exerted their inhibitory actions efficacy through modulation distinct metabolites involved glycerophospholipid purine metabolic pathways.

Язык: Английский

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Microbiome-metabolomics-based insight into the protective effects of dietary fiber from sweetpotato residues on the high-fat diet-induced intestinal integrity damage

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133620 - 133620

Опубликована: Июль 2, 2024

Язык: Английский

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Insights into impact of chlorogenic acid on multi-scale structure and digestive properties of lotus seed starch under autoclaving treatment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134863 - 134863

Опубликована: Авг. 19, 2024

Язык: Английский

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Exploring the mechanism of flavonoids modification by dimerization strategies and their potential to enhance biological activity

Food Chemistry, Год журнала: 2024, Номер 467, С. 142266 - 142266

Опубликована: Ноя. 27, 2024

Язык: Английский

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