Synthesis of Chitosan-Based Gold Nanoparticles: Antimicrobial and Wound-Healing Activities

Polymers, Год журнала: 2022, Номер 14(11), С. 2293 - 2293

Опубликована: Июнь 5, 2022

The global spread of multidrug-resistant bacteria has become a significant hazard to public health, and more effective antibacterial agents are required. Therefore, this study describes the preparation, characterization, evaluation gold nanoparticles modified with chitosan (Chi/AuNPs) as reducing stabilizing agent efficient antimicrobial effects. In recent years, development an ecofriendly method for synthesizing metal attracted lot interest in field nanotechnology. Colloidal (AuNPs) were prepared by chemical reduction ions presence (Chi), giving Chi/AuNPs. characterization Chi/AuNPs was carried out transmission electron microscopy (TEM), scanning (SEM), Fourier-transform infrared (FTIR), X-ray diffraction (XRD). appeared spherical monodispersed, diameter ranging between 20 120 nm. synergistic effects AuNPs Chi led disruption bacterial membranes. maximum inhibitory impact seen against P. aeruginosa at 500 µg/mL, zone inhibition 26 ± 1.8 mm, whereas least effect reported S. aureus, 16 2.1 mm highest dose tested. Moreover, exhibited antifungal activity toward Candida albicans when MIC 62.5 µg/mL. Cell viability proliferation developed nanocomposite evaluated using sulphorhodamine B (SRB) assay half concentration (IC50) 111.1 vitro wound-healing model revealed that Chi/AuNP dressing provides relatively rapid efficacious ability, making obtained promising candidate improved bandage materials.

Язык: Английский

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Nanoparticles incorporated in nanofibers using electrospinning: A novel nano-in-nano delivery system

Journal of Controlled Release, Год журнала: 2022, Номер 350, С. 421 - 434

Опубликована: Авг. 30, 2022

Язык: Английский

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Enhancing wound healing and minimizing scarring: A comprehensive review of nanofiber technology in wound dressings

Progress in Materials Science, Год журнала: 2024, Номер 147, С. 101350 - 101350

Опубликована: Авг. 6, 2024

Wound healing is a complex biological process that, when impaired, can lead to the formation of scars. Electrospun nanofibrous wound dressings have emerged as promising option for promoting scar-free healing. This paper explores role physical, compositional, and chemical cues, each contributing remarkable potential these dressings. The physical properties dressings, such porosity mechanical characteristics, guide cellular behaviors promote vascularization, fostering conducive environment reduced scarring. Furthermore, integration natural polymers that mimic skin's extracellular matrix, known compositional adds another layer complexity As therapeutic agents demonstrated their combat chronic scenarios leading scar formation. However, achieving desired effect hinges on nature controlled release. Therefore, also delves into various loading techniques tailoring release profiles bioactive agents. Although electrospun are viable commercial product remains elusive. gap be attributed lack comprehensive in vivo studies, particularly animal models human

Язык: Английский

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Fabrication of Bilayer Nanofibrous-Hydrogel Scaffold from Bacterial Cellulose, PVA, and Gelatin as Advanced Dressing for Wound Healing and Soft Tissue Engineering

ACS Omega, Год журнала: 2024, Номер 9(6), С. 6527 - 6536

Опубликована: Фев. 1, 2024

Tissue engineering is currently one of the fastest-growing areas engineering, requiring fabrication advanced and multifunctional materials that can be used as scaffolds or dressings for tissue regeneration. In this work, we report a bilayer material prepared by electrospinning hybrid poly(vinyl alcohol) (PVA) bacterial cellulose (BC NFs) (top layer) over highly interconnected porous 3D gelatin-PVA hydrogel obtained freeze-drying process (bottom layer). The techniques were combined to produce an with synergistic effects on physical biological properties two materials. was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), water contact measurement system (WCMS). Studies swelling, degradability, porosity, drug release, cellular antibacterial activities performed standardized procedures assays. FTIR confirmed cross-linking both top bottom layers, SEM showed structure layer, random deposition NFs surface, aligned in cross section. angle (WCA) hydrophilic surface material. Swelling analysis high degradation good stability. released Ag-sulfadiazine sustained controlled manner against severe disease-causing gram + ive −ive (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa) strains. vitro studies fibroblasts (3T3) human embryonic kidneys (HEK-293), which desirable cell viability, proliferation, adhesion bilayer. Thus, effect resulted potential wound dressing healing soft engineering.

Язык: Английский

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Electrospun hybrid nanofibers: Fabrication, characterization, and biomedical applications

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Дек. 1, 2022

Nanotechnology is one of the most promising technologies available today, holding tremendous potential for biomedical and healthcare applications. In this field, there an increasing interest in use polymeric micro/nanofibers construction structures. Due to its applications various fields like pharmaceutics biomedicine, electrospinning process has gained considerable attention producing nano-sized fibers. Electrospun nanofiber membranes have been used drug delivery, controlled release, regenerative medicine, tissue engineering, biosensing, stent coating, implants, cosmetics, facial masks, theranostics. Various natural synthetic polymers successfully electrospun into ultrafine Although biopolymers demonstrate exciting properties such as good biocompatibility, non-toxicity, biodegradability, they possess poor mechanical properties. Hybrid nanofibers from bio combine characteristics with those polymers, high strength stability. addition, a variety functional agents, nanoparticles biomolecules, can be incorporated create multifunctional hybrid nanofibers. remarkable nanofibers, latest research on unique highlighted study. Moreover, established fabrication techniques, especially electrospinning-based methods, well emerging strategies characterization are summarized. Finally, development application discussed.

Язык: Английский

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Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(2), С. 115 - 115

Опубликована: Фев. 18, 2023

Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of function affected regions structures, resulting in dehydration wound infections. Many nanocarriers, such as lipid-based systems or biobased biodegradable polymers their associated platforms, favorable healing due to ability promote cell adhesion migration, thus improving reducing scarring. Hence, many researchers focused developing new dressings based compounds with desirable effects. However, when applied healing, some problems occur, high cost public health, novel emphasizing reduced costs, increasing quality treatment outcomes. The integrated hybrid nanocarriers (LNCs) polymer-based can be promising solution for above process. Furthermore, drug delivery showed effective release therapeutic agents, suitable mimicking physiological environment, improvement single system. This review highlights recent advances role carriers healing.

Язык: Английский

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An Overview of the Electrospinning of Polymeric Nanofibers for Biomedical Applications Related to Drug Delivery

Advanced Engineering Materials, Год журнала: 2023, Номер 26(1)

Опубликована: Ноя. 14, 2023

Electrospinning is a prominent technique for micro/nanofiber production and has received significant attention in the 21 st century. It enables of ultrafine fibers using variety polymers, including synthetic, natural, hybrid materials. Electrospun nanofibers (NFs) possess unique properties such as high surface‐to‐volume ratio, tunable pore structures, customizable composition, making them highly desirable various fields biomedical science, textiles, sensors, filters, energy, packaging. Herein, particular will be given to application NFs fields. The use delivery drugs, growth factors, proteins, nanoparticles, etc., holds promise field science. To combine these compounds with NFs, electrospinning techniques have been developed outstanding improvements, based on requirements type, different processes are favored. In this review, most common drug loading methods into generally used synthetic/natural polymers NF production, their systems, tissue engineering, wound dressing mentioned. Finally, challenges future perspectives above mentioned applications discussed.

Язык: Английский

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Wound Dressing with Electrospun Core-Shell Nanofibers: From Material Selection to Synthesis

Polymers, Год журнала: 2024, Номер 16(17), С. 2526 - 2526

Опубликована: Сен. 5, 2024

Skin, the largest organ of human body, accounts for protecting against external injuries and pathogens. Despite possessing inherent self-regeneration capabilities, repair skin lesions is a complex time-consuming process yet vital to preserving its critical physiological functions. The dominant treatment involves application dressing protect wound, mitigate risk infection, decrease likelihood secondary injuries. Pursuing solutions accelerating wound healing has resulted in groundbreaking advancements materials science, from hydrogels hydrocolloids foams micro-/nanofibers. Noting convenience flexibility design, nanofibers merit high surface-area-to-volume ratio, controlled release therapeutics, mimicking extracellular matrix, excellent mechanical properties. Core-shell bring even further prospects realm dressings upon separate compartments with independent functionality, adapted profiles bioactive agents, better moisture management. In this review, we highlight core-shell applications featuring survey on common synthesis methods. Our discussion embodies process, optimal characteristics, current organic inorganic material repertoire multifunctional nanofibers, techniques fabricate proper coaxial structures. We also provide an overview antibacterial nanomaterials emphasis their crystalline structures, properties, conclude outlook potential offered by toward more advanced design effective healing.

Язык: Английский

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Multifunctional silk fibroin and cellulose acetate composite nanofibers incorporated with palladium and platinum nanoparticles for enhanced wound healing: Comprehensive characterization and in vivo assessment

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 684, С. 133153 - 133153

Опубликована: Янв. 15, 2024

Язык: Английский

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Antibacterial polylysine-containing hydrogels for hemostatic and wound healing applications: preparation methods, current advances and future perspectives

Biomaterials Science, Год журнала: 2024, Номер 12(13), С. 3293 - 3320

Опубликована: Янв. 1, 2024

Polylysine, renowned for its outstanding antibacterial efficacy, has shown significant promise in the biomedical field. This review presents various preparation methods and recent advances polylysine-containing hydrogels to promote wound healing.

Язык: Английский

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