Synthesis of Chitosan-Based Gold Nanoparticles: Antimicrobial and Wound-Healing Activities

Polymers, Journal Year: 2022, Volume and Issue: 14(11), P. 2293 - 2293

Published: June 5, 2022

The global spread of multidrug-resistant bacteria has become a significant hazard to public health, and more effective antibacterial agents are required. Therefore, this study describes the preparation, characterization, evaluation gold nanoparticles modified with chitosan (Chi/AuNPs) as reducing stabilizing agent efficient antimicrobial effects. In recent years, development an ecofriendly method for synthesizing metal attracted lot interest in field nanotechnology. Colloidal (AuNPs) were prepared by chemical reduction ions presence (Chi), giving Chi/AuNPs. characterization Chi/AuNPs was carried out transmission electron microscopy (TEM), scanning (SEM), Fourier-transform infrared (FTIR), X-ray diffraction (XRD). appeared spherical monodispersed, diameter ranging between 20 120 nm. synergistic effects AuNPs Chi led disruption bacterial membranes. maximum inhibitory impact seen against P. aeruginosa at 500 µg/mL, zone inhibition 26 ± 1.8 mm, whereas least effect reported S. aureus, 16 2.1 mm highest dose tested. Moreover, exhibited antifungal activity toward Candida albicans when MIC 62.5 µg/mL. Cell viability proliferation developed nanocomposite evaluated using sulphorhodamine B (SRB) assay half concentration (IC50) 111.1 vitro wound-healing model revealed that Chi/AuNP dressing provides relatively rapid efficacious ability, making obtained promising candidate improved bandage materials.

Language: Английский

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Nanoparticles incorporated in nanofibers using electrospinning: A novel nano-in-nano delivery system

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 350, P. 421 - 434

Published: Aug. 30, 2022

Language: Английский

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Enhancing wound healing and minimizing scarring: A comprehensive review of nanofiber technology in wound dressings

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 147, P. 101350 - 101350

Published: Aug. 6, 2024

Wound healing is a complex biological process that, when impaired, can lead to the formation of scars. Electrospun nanofibrous wound dressings have emerged as promising option for promoting scar-free healing. This paper explores role physical, compositional, and chemical cues, each contributing remarkable potential these dressings. The physical properties dressings, such porosity mechanical characteristics, guide cellular behaviors promote vascularization, fostering conducive environment reduced scarring. Furthermore, integration natural polymers that mimic skin's extracellular matrix, known compositional adds another layer complexity As therapeutic agents demonstrated their combat chronic scenarios leading scar formation. However, achieving desired effect hinges on nature controlled release. Therefore, also delves into various loading techniques tailoring release profiles bioactive agents. Although electrospun are viable commercial product remains elusive. gap be attributed lack comprehensive in vivo studies, particularly animal models human

Language: Английский

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Fabrication of Bilayer Nanofibrous-Hydrogel Scaffold from Bacterial Cellulose, PVA, and Gelatin as Advanced Dressing for Wound Healing and Soft Tissue Engineering

ACS Omega, Journal Year: 2024, Volume and Issue: 9(6), P. 6527 - 6536

Published: Feb. 1, 2024

Tissue engineering is currently one of the fastest-growing areas engineering, requiring fabrication advanced and multifunctional materials that can be used as scaffolds or dressings for tissue regeneration. In this work, we report a bilayer material prepared by electrospinning hybrid poly(vinyl alcohol) (PVA) bacterial cellulose (BC NFs) (top layer) over highly interconnected porous 3D gelatin-PVA hydrogel obtained freeze-drying process (bottom layer). The techniques were combined to produce an with synergistic effects on physical biological properties two materials. was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), water contact measurement system (WCMS). Studies swelling, degradability, porosity, drug release, cellular antibacterial activities performed standardized procedures assays. FTIR confirmed cross-linking both top bottom layers, SEM showed structure layer, random deposition NFs surface, aligned in cross section. angle (WCA) hydrophilic surface material. Swelling analysis high degradation good stability. released Ag-sulfadiazine sustained controlled manner against severe disease-causing gram + ive −ive (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa) strains. vitro studies fibroblasts (3T3) human embryonic kidneys (HEK-293), which desirable cell viability, proliferation, adhesion bilayer. Thus, effect resulted potential wound dressing healing soft engineering.

Language: Английский

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Electrospun hybrid nanofibers: Fabrication, characterization, and biomedical applications

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 1, 2022

Nanotechnology is one of the most promising technologies available today, holding tremendous potential for biomedical and healthcare applications. In this field, there an increasing interest in use polymeric micro/nanofibers construction structures. Due to its applications various fields like pharmaceutics biomedicine, electrospinning process has gained considerable attention producing nano-sized fibers. Electrospun nanofiber membranes have been used drug delivery, controlled release, regenerative medicine, tissue engineering, biosensing, stent coating, implants, cosmetics, facial masks, theranostics. Various natural synthetic polymers successfully electrospun into ultrafine Although biopolymers demonstrate exciting properties such as good biocompatibility, non-toxicity, biodegradability, they possess poor mechanical properties. Hybrid nanofibers from bio combine characteristics with those polymers, high strength stability. addition, a variety functional agents, nanoparticles biomolecules, can be incorporated create multifunctional hybrid nanofibers. remarkable nanofibers, latest research on unique highlighted study. Moreover, established fabrication techniques, especially electrospinning-based methods, well emerging strategies characterization are summarized. Finally, development application discussed.

Language: Английский

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Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(2), P. 115 - 115

Published: Feb. 18, 2023

Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of function affected regions structures, resulting in dehydration wound infections. Many nanocarriers, such as lipid-based systems or biobased biodegradable polymers their associated platforms, favorable healing due to ability promote cell adhesion migration, thus improving reducing scarring. Hence, many researchers focused developing new dressings based compounds with desirable effects. However, when applied healing, some problems occur, high cost public health, novel emphasizing reduced costs, increasing quality treatment outcomes. The integrated hybrid nanocarriers (LNCs) polymer-based can be promising solution for above process. Furthermore, drug delivery showed effective release therapeutic agents, suitable mimicking physiological environment, improvement single system. This review highlights recent advances role carriers healing.

Language: Английский

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An Overview of the Electrospinning of Polymeric Nanofibers for Biomedical Applications Related to Drug Delivery

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 26(1)

Published: Nov. 14, 2023

Electrospinning is a prominent technique for micro/nanofiber production and has received significant attention in the 21 st century. It enables of ultrafine fibers using variety polymers, including synthetic, natural, hybrid materials. Electrospun nanofibers (NFs) possess unique properties such as high surface‐to‐volume ratio, tunable pore structures, customizable composition, making them highly desirable various fields biomedical science, textiles, sensors, filters, energy, packaging. Herein, particular will be given to application NFs fields. The use delivery drugs, growth factors, proteins, nanoparticles, etc., holds promise field science. To combine these compounds with NFs, electrospinning techniques have been developed outstanding improvements, based on requirements type, different processes are favored. In this review, most common drug loading methods into generally used synthetic/natural polymers NF production, their systems, tissue engineering, wound dressing mentioned. Finally, challenges future perspectives above mentioned applications discussed.

Language: Английский

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Multifunctional silk fibroin and cellulose acetate composite nanofibers incorporated with palladium and platinum nanoparticles for enhanced wound healing: Comprehensive characterization and in vivo assessment

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 684, P. 133153 - 133153

Published: Jan. 15, 2024

Language: Английский

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Antibacterial polylysine-containing hydrogels for hemostatic and wound healing applications: preparation methods, current advances and future perspectives

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(13), P. 3293 - 3320

Published: Jan. 1, 2024

Polylysine, renowned for its outstanding antibacterial efficacy, has shown significant promise in the biomedical field. This review presents various preparation methods and recent advances polylysine-containing hydrogels to promote wound healing.

Language: Английский

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Bilayer regenerated cellulose/quaternized chitosan-hyaluronic acid/collagen electrospun scaffold for potential wound healing applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129661 - 129661

Published: Jan. 23, 2024

Language: Английский

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