A mini review on green nanotechnology and its development in biological effects

Archives of Microbiology, Год журнала: 2023, Номер 205(4)

Опубликована: Март 22, 2023

The utilization of living organisms for the creation inorganic nanoscale particles is a potential new development in realm biotechnology. An essential milestone nanotechnology process creating dependable and environmentally acceptable metallic nanoparticles. Due to its increasing popularity ease, use ambient biological resources quickly becoming more significant this field study. phrase "green nanotechnology" has gained lot attention refers variety procedures that eliminate or do away with hazardous compounds repair environment. Green nanomaterials can be used biotechnological sectors such as medicine biology, well food textile industries, wastewater treatment agriculture field. construction an updated level knowledge study systems might support revolutionize nanoparticles (NPs) are presented article.

Язык: Английский

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Potential Antimicrobial and Antibiofilm Properties of Copper Oxide Nanoparticles: Time-Kill Kinetic Essay and Ultrastructure of Pathogenic Bacterial Cells

Applied Biochemistry and Biotechnology, Год журнала: 2022, Номер 195(1), С. 467 - 485

Опубликована: Сен. 10, 2022

Abstract Mycosynthesis of nanoparticle (NP) production is a potential ecofriendly technology for large scale production. In the present study, copper oxide nanoparticles (CuONPs) have been synthesized from live cell filtrate fungus Penicillium chrysogenum . The created CuONPs were characterized via several techniques, namely Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscope (TEM), scanning (SEM), and energy-dispersive spectroscopy (EDX). Furthermore, biosynthesized performed against biofilm forming Klebsiella oxytoca ATCC 51,983, Escherichia coli 35,218, Staphylococcus aureus 25,923, Bacillus cereus 11,778. anti-bacterial activity result was shown with zone inhibition determined to be 14 ± 0.31 mm, 16 0.53 11 0.57 10 mm respectively. more susceptible minimal inhibitory concentration (MIC) values 6.25 3.12 µg/mL, respectively, while , MIC value 12.5 25 μg/mL, minimum (MBIC) evident, that excellent anti-biofilm at sub-MIC levels reducing formation by 49% 59% results indicated MBIC on higher than 200 μg/mL 256 suggesting these could not inhibit mature formatted in vitro. Overall, all clearly confirmed ability prepared offer smart approach biomedical therapy resistant microorganisms because its promoted antimicrobial action, but only specified purposes.

Язык: Английский

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Synthesis of Silver Nanocomposite Based on Carboxymethyl Cellulose: Antibacterial, Antifungal and Anticancer Activities

Polymers, Год журнала: 2022, Номер 14(16), С. 3352 - 3352

Опубликована: Авг. 17, 2022

Traditional cancer treatments include surgery, radiation, and chemotherapy. According to medical sources, chemotherapy is still the primary method for curing or treating today has been a major contributor recent decline in mortality. Nanocomposites based on polymers metal nanoparticles have recently received attention of researchers. In current study, nanocomposite was fabricated carboxymethyl cellulose silver (CMC-AgNPs) their antibacterial, antifungal, anticancer activities were evaluated. The antibacterial results revealed that CMC-AgNPs promising activity against Gram-negative (Klebsiella oxytoca Escherichia coli) Gram-positive bacteria (Bacillus cereus Staphylococcus aureus). Moreover, exhibited antifungal filamentous fungi such as Aspergillus fumigatus, A. niger, terreus. Concerning HepG2 hepatocellular cell line, lowest IC50 values (7.9 ± 0.41 µg/mL) recorded CMC-AgNPs, suggesting strong cytotoxic effect liver cells. As result, our findings suggest antitumor these CMC-Ag due induction apoptosis necrosis hepatic cells via increased caspase-8 -9 diminished levels VEGFR-2. conclusion, activities, which can be used pharmaceutical fields.

Язык: Английский

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Biosynthesis of Silver and Gold Nanoparticles and Their Efficacy Towards Antibacterial, Antibiofilm, Cytotoxicity, and Antioxidant Activities

Applied Biochemistry and Biotechnology, Год журнала: 2022, Номер 195(2), С. 1158 - 1183

Опубликована: Ноя. 7, 2022

The World Health Organization (WHO) reports that the emergence of multidrug-resistant and slow advent novel more potent antitumor antimicrobial chemotherapeutics continue to be highest concern for human health. Additionally, stability, low solubility, negative effects existing drugs make them ineffective. Studies into alternative tactics tackle such tenacious diseases was sparked by anticancer antibacterial. Silver (Ag) gold (Au) nanoparticles (NPs) were created from Trichoderma saturnisporum, much productive fungal strain. Functional extracellular enzymes proteins carried out activities synthesis capping generated nano-metals. Characterization done on obtained Ag-NPs Au-NPs through UV-vis, FTIR, XRD, TEM, SEM. versus methicillin-sensitive Staphylococcus aureus (MSSA) methicillin-resistant (MRSA), Pseudomonas aeruginosa, Klebsiella pneumoniae, antibacterial assessed. In particular, effective against pathogenic bacteria than Au-NPs. Furthermore, antibiofilm study shown had activity Ag-NPs. Interestingly, applying DPPH procedure, these noble metallic NPs antioxidant activity, in which IC50 73.5 μg/mL 190.0 μg/mL, respectively. According cytotoxicity evaluation results, alteration cells as loss their typical shape, partial or complete monolayer, granulation, shrinking, cell rounding with normal Vero 693.68 661.24 Au-NPs, While cancer (Mcf7) 370.56 394.79 produced via green have potential employed medical industry beneficial nanocompounds.

Язык: Английский

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Green Biosynthesis of Selenium Nanoparticles Using Orange Peel Waste: Characterization, Antibacterial and Antibiofilm Activities against Multidrug-Resistant Bacteria

Life, Год журнала: 2022, Номер 12(6), С. 893 - 893

Опубликована: Июнь 15, 2022

There is an increase of pathogenic multidrug-resistant bacteria globally due to the misuse antibiotics. Recently, more scientists used metal nanoparticles counteract antibacterial resistance. In this study, orange peel waste (OPW) was for selenium nanoparticles' (Se-NPs) biosynthesis through green and ecofriendly method, their applications as antibiofilm agents. Green biosynthesized Se-NPs were characterized using FTIR, XRD, SEM, EDAX, TEM. Characterization results revealed that highly crystalline, spherical, polydisperse, had sizes in range 16-95 nm. The evaluated activities against bacteria. Results illustrated exhibited potential activity Gram-positive (S. aureus ATCC 29213 biofilm-producing clinical isolates S. aureus) Gram-negative (Pseudomonas aeruginosa PAO1, MDR, biofilm, quorum-sensing producing MDR P. aeruginosa, E. coli, K. pneumonia). Moreover, most sensitive at 1000 µg/mL, where inhibition zone 35 mm MIC 25 µg/mL. Furthermore, 0.25 0.5 decreased biofilm significantly. largest noticed pneumonia, which 62% 92% MIC, respectively. conclusion, successfully OPW method promising bacteria, can be later fighting resistant

Язык: Английский

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Phytofabrication of zinc oxide nanoparticles with advanced characterization and its antioxidant, anticancer, and antimicrobial activity against pathogenic microorganisms

Biomass Conversion and Biorefinery, Год журнала: 2022, Номер 13(1), С. 417 - 430

Опубликована: Окт. 28, 2022

Язык: Английский

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Nanocomposite based on gold nanoparticles and carboxymethyl cellulose: Synthesis, characterization, antimicrobial, and anticancer activities

Journal of Drug Delivery Science and Technology, Год журнала: 2022, Номер 77, С. 103874 - 103874

Опубликована: Окт. 7, 2022

Язык: Английский

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Nanomaterials for wound healing: Current status and futuristic frontier

Biomedical Technology, Год журнала: 2023, Номер 6, С. 26 - 45

Опубликована: Ноя. 8, 2023

Wound healing is a complex process that involves variety of physical, chemical, and biological processes. Because their remarkable characteristics capabilities, nanomaterials have recently emerged as potential therapeutic agents for wound healing. Many different nanomaterial-based wound-healing treatments been created put into widespread use. In this review, we compile the most recent research on cutting-edge healing, including both organic inorganic nanomaterials. We highlight prospective approaches developing therapy procedures talk about benefits limitations these treatments. Future prospects therapies based are discussed, need to address toxicity concerns, scalability production, long-term stability The safety effectiveness depend further investigation design, interactions with systems, results rigorous preclinical clinical trials. There great dramatic improvement in patient outcomes introduction therapies.

Язык: Английский

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Baker’s Yeast-Mediated Silver Nanoparticles: Characterisation and Antimicrobial Biogenic Tool for Suppressing Pathogenic Microbes

BioNanoScience, Год журнала: 2022, Номер 12(4), С. 1220 - 1229

Опубликована: Авг. 18, 2022

Язык: Английский

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Unveiling Antimicrobial and Insecticidal Activities of Biosynthesized Selenium Nanoparticles Using Prickly Pear Peel Waste

Journal of Functional Biomaterials, Год журнала: 2022, Номер 13(3), С. 112 - 112

Опубликована: Авг. 2, 2022

In the current study, prickly pear peel waste (PPPW) extract was used for biosynthesis of selenium nanoparticles through a green and eco-friendly method first time. The biosynthesized SeNPs were characterized using UV-Vis, XRD, FTIR, TEM, SEM, EDX, mapping. Characterization results revealed that spherical, polydisperse, highly crystalline, had sizes in range 10-87.4 nm. Antibacterial, antifungal, insecticidal activities evaluated. Results exhibited promising antibacterial against Gram negative (E. coli P. aeruginosa) positive (B. subtilis S. aureus) bacteria where MICs 125, 62.5, 15.62 µg/mL, respectively. Moreover, showed potential antifungal activity toward Candida albicans Cryptococcus neoformans 3.9 7.81 Furthermore, tested crud severely induced larvicidal mosquitoes with LC50 LC90 219.841, 950.087 mg/L 75.411, 208.289 mg/L, fecundity hatchability C. pipiens mosquito significantly decreased as applied concentrations increased either crude or fabricated extracts. conclusion, have antibacterial, activities, which can be biomedical environmental applications.

Язык: Английский

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