Genetics in the diagnosis and treatment of cardiovascular diseases DOI Open Access

Kevin P. Bliden,

Sahib Singh,

Roni Shanoada

et al.

Journal of Translational Genetics and Genomics, Journal Year: 2024, Volume and Issue: 8(2), P. 186 - 206

Published: April 15, 2024

Cardiovascular diseases (CVDs) remain one of the leading causes morbidity and mortality worldwide, with genetics being a major risk factor. Genetic cardiovascular disease can occur either because single variant (Mendelian) or polygenic influences has been linked to inherited conditions (ICC) such as arrhythmias, cardiomyopathies, dyslipidemias, aortopathies which are significant factors sudden cardiac death in young adults. Timely screening, diagnosis, management ICC not only provide life-saving treatment patient, but also identify at-risk family members. The field pharmacogenomics (PGx) helped understand variable action medications clopidogrel, aspirin, warfarin, statin according genotype. Newer technologies multi-omics combine data from multiple sources genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome. These advancements contribute development prediction scores precision medicine tailored individual genotypes. Substantial strides have made genetic-based therapeutics, gene editing technologies, drug delivery systems, significantly expanded options for patients acquired CVDs. Although variable, country- society-specific guidelines on genetic testing PGx continuously updated keep up ongoing research field. Along appropriate knowledge, other including cost availability play vital role usage by both physicians patients. With advent newer CVDs, key factor is counselors (GCs) who specifically trained genomics. current review provides concise summary diagnosis

Language: Английский

Importance of long non-coding RNAs in the pathogenesis, diagnosis, and treatment of myocardial infarction DOI Creative Commons
Maryam Zolfaghari Dehkharghani, Safa Mousavi,

Nazanin Kianifard

et al.

IJC Heart & Vasculature, Journal Year: 2024, Volume and Issue: 55, P. 101529 - 101529

Published: Oct. 17, 2024

Language: Английский

Citations

5
Cardioprotective Effects of hUCMSCs-Exosi-EGR1 MN Patch in MI/RI by Modulating Oxidative Stress and Mitophagy DOI Creative Commons
Chenyang Huang, Xun Zhang,

Shi-Xiong Wu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101500 - 101500

Published: Jan. 19, 2025

In an effort to address the detrimental effects of myocardial ischemia/reperfusion injury (MI/RI), this study introduces a novel therapeutic strategy that involves microneedle (MN) patch loaded with exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) and carrying small interfering RNA (siRNA) targeting early growth response-1 (EGR1). By delivering hUCMSCs-derived containing EGR1 siRNA (hUCMSCs-Exosi-EGR1), MN demonstrated promising cardioprotective in both vitro vivo models MI/RI. The results highlighted efficacy Exosi-EGR1 enhancing cardiomyocyte viability, attenuating oxidative stress levels, fostering mitophagy regulation. Moreover, exhibited excellent mechanical properties sustained drug release characteristics when embedded Gelatin methacryloyl (GelMA) matrix. Noteworthy outcomes experiments included significant improvements cardiac function, reduced fibrosis, decreased apoptosis rates MI/RI mice, emphasizing potential value mitigating through modulation mechanisms.

Language: Английский

Citations

0
miRNA, lncRNA and circRNA: targeted molecules with therapeutic promises in Mycoplasma pneumoniae infection DOI
Tian Gan,

Jianwei Yu,

Jun He

et al.

Archives of Microbiology, Journal Year: 2023, Volume and Issue: 205(8)

Published: July 21, 2023

Language: Английский

Citations

8
Roles of extracellular vesicles derived from healthy and obese adipose tissue in inter-organ crosstalk and potential clinical implication DOI Creative Commons
Yue Han, Sheng Ye, Bowen Liu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 29, 2024

Extracellular vesicles (EVs) are nanovesicles containing bioactive molecules including proteins, nucleic acids and lipids that mediate intercellular inter-organ communications, holding promise as potential therapeutics for multiple diseases. Adipose tissue (AT) serves a dynamically distributed energy storage organ throughout the body, whose accumulation leads to obesity, condition characterized by infiltration with abundant immune cells. Emerging evidence has illustrated EVs secreted AT novel class of adipokines regulate homeostasis between peripheral organs. However, most studies focused on investigations derived from adipocytes or adipose-derived stem cells (ADSCs), summarization functions in cellular crosstalk directly adipose (AT-EVs) still limited. Here, we provide systemic summary key components healthy tissue, showing their significance recovery metabolic regulation. Also, discuss harmful influences obese distal Furthermore, elucidate applications constraints patients lipoaspirates therapeutic agents, highlighting AT-EVs valuable biological material broad prospects future clinical use.

Language: Английский

Citations

1
Genetics in the diagnosis and treatment of cardiovascular diseases DOI Open Access

Kevin P. Bliden,

Sahib Singh,

Roni Shanoada

et al.

Journal of Translational Genetics and Genomics, Journal Year: 2024, Volume and Issue: 8(2), P. 186 - 206

Published: April 15, 2024

Cardiovascular diseases (CVDs) remain one of the leading causes morbidity and mortality worldwide, with genetics being a major risk factor. Genetic cardiovascular disease can occur either because single variant (Mendelian) or polygenic influences has been linked to inherited conditions (ICC) such as arrhythmias, cardiomyopathies, dyslipidemias, aortopathies which are significant factors sudden cardiac death in young adults. Timely screening, diagnosis, management ICC not only provide life-saving treatment patient, but also identify at-risk family members. The field pharmacogenomics (PGx) helped understand variable action medications clopidogrel, aspirin, warfarin, statin according genotype. Newer technologies multi-omics combine data from multiple sources genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome. These advancements contribute development prediction scores precision medicine tailored individual genotypes. Substantial strides have made genetic-based therapeutics, gene editing technologies, drug delivery systems, significantly expanded options for patients acquired CVDs. Although variable, country- society-specific guidelines on genetic testing PGx continuously updated keep up ongoing research field. Along appropriate knowledge, other including cost availability play vital role usage by both physicians patients. With advent newer CVDs, key factor is counselors (GCs) who specifically trained genomics. current review provides concise summary diagnosis

Language: Английский

Citations

0