Post-traumatic stress disorder

Nature Reviews Disease Primers, Год журнала: 2015, Номер 1(1)

Опубликована: Окт. 7, 2015

Язык: Английский

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Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations

Dialogues in Clinical Neuroscience, Год журнала: 2015, Номер 17(2), С. 141 - 150

Опубликована: Июнь 30, 2015

Approximately half of people with post-traumatic stress disorder (PTSD) also suffer from Major Depressive Disorder (MDD). The current paper examines evidence for two explanations this comorbidity. First, that the comorbidity reflects overlapping symptoms in disorders. Second, co-occurrence PTSD and MDD is not an artifact, but represents a trauma-related phenotype, possibly subtype PTSD. Support latter explanation inferred literature risk biological correlates MDD, including molecular processes. Treatment implications are considered. Aproximadamente la mitad de las personas con trastorno por estrés postraumático (TEPT) también sufren un depresivo mayor (TDM). Este artículo examina evidencia para dos explicaciones esta co-morbilidad. Primero, que comorbilidad refleja una sobreposición síntomas en los trastornos. Segundo, ocurrencia simultánea TEPT y TDM no es artefacto, sino representa fenotipo relacionado el trauma, posiblemente subtipo TEPT. El soporte última explicación se infiere literatura revisa riesgo correlatos biológicos del TDM, incluyendo procesos moleculares. También consideran repercusiones terapéuticas comorbilidad.Environ moitié des personnes qui présentent trouble post-traumatique (TSPT) souffrent aussi d'un dépressif caractérisé (majeur) Cet article analyse les données relatives à deux explications cette comorbidité. Premièrement, dans troubles, comorbidité révèle symptômes chevauchement. Deuxièmement, l'apparition concomitante TSPT et n'est pas artefact, mais représente phénotype lié au traumatisme, probablement sous-type TSPT. La littérature, le risque liens biologiques du compris processus moléculaires s'y rapportent, est faveur dernière explication. Nous examinons attentivement thérapeutiques

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Post‐traumatic stress disorder: a state‐of‐the‐art review of evidence and challenges

World Psychiatry, Год журнала: 2019, Номер 18(3), С. 259 - 269

Опубликована: Сен. 9, 2019

Post‐traumatic stress disorder (PTSD) is arguably the most common psychiatric to arise after exposure a traumatic event. Since its formal introduction in DSM‐III 1980, knowledge has grown significantly regarding causes, maintaining mechanisms and treatments. Despite this increased understanding, however, actual definition of remains controversial. The DSM‐5 ICD‐11 define differently, reflecting disagreements field about whether construct PTSD should encompass broad array psychological manifestations that trauma or be focused more specifically on memory phenomena. This controversy over clarifying phenotype limited capacity identify biomarkers specific stress. review provides an up‐to‐date outline current definitions PTSD, known prevalence risk factors, main models explain disorder, evidence‐supported A major conclusion that, although trauma‐focused cognitive behavior therapy best‐validated treatment for it stagnated recent decades, only two‐thirds patients respond adequately intervention. Moreover, people with do not access evidence‐based treatment, situation much worse low‐ middle‐income countries. Identifying processes can overcome these barriers better management outstanding challenge.

Язык: Английский

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A systematic review of the comorbidity between PTSD and alcohol misuse

Social Psychiatry and Psychiatric Epidemiology, Год журнала: 2014, Номер 49(9), С. 1401 - 1425

Опубликована: Март 18, 2014

Язык: Английский

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Sleep and anxiety: From mechanisms to interventions

Sleep Medicine Reviews, Год журнала: 2021, Номер 61, С. 101583 - 101583

Опубликована: Дек. 8, 2021

Язык: Английский

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Network Mechanisms of Clinical Response to Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder and Major Depressive Disorder

Biological Psychiatry, Год журнала: 2017, Номер 83(3), С. 263 - 272

Опубликована: Авг. 8, 2017

Язык: Английский

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Animal models of PTSD: a challenge to be met

Molecular Psychiatry, Год журнала: 2018, Номер 24(8), С. 1135 - 1156

Опубликована: Окт. 19, 2018

Abstract Recent years have seen increased interest in psychopathologies related to trauma exposure. Specifically, there has been a growing awareness posttraumatic stress disorder (PTSD) part due terrorism, climate change-associated natural disasters, the global refugee crisis, and violence overpopulated urban areas. However, notwithstanding disorder, increasing number of patients, devastating impact on lives patients their families, efficacy available treatments remains limited highly unsatisfactory. A major scientific effort is therefore devoted unravel neural mechanisms underlying PTSD with aim paving way developing novel or improved treatment approaches drugs treat PTSD. One tools used gain insight into understanding physiological neuronal diseases for development use animal models human diseases. While much progress made using these conditioned fear memory, gained knowledge not yet led better options patients. This poor translational outcome already some scientists pharmaceutical companies, who do general hold opinions against models, propose that those should be abandoned. Here, we critically examine aspects may contributed relative lack translatability, including focus exposure trauma, overlooking individual sex differences, contribution risk factors. Based findings from recent years, research-based modifications believe are required order overcome shortcomings previous practice. These include usage which incorporate factors behavioral profiling analysis individuals sample. aimed address such as predisposition resilience, thus taking consideration fact only fraction exposed develop We suggest an appropriate shift practice, valuable tool enhance our memory processes, but could serve effective platforms PTSD, drug testing.

Язык: Английский

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The efficacy of virtual reality exposure therapy for PTSD symptoms: A systematic review and meta-analysis

Journal of Affective Disorders, Год журнала: 2019, Номер 257, С. 698 - 709

Опубликована: Июль 30, 2019

Язык: Английский

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Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis

Depression and Anxiety, Год журнала: 2020, Номер 38(3), С. 286 - 306

Опубликована: Ноя. 22, 2020

There is consistent evidence that mood disorders often co-occur with anxiety disorders, however, the strength of association these two broad groups has been challenging to summarize across different studies. The aim was conduct a meta-analysis publications reporting on pairwise comorbidity between and after sorting into comparable study types. We searched MEDLINE, Embase, CINAHL, Web Science, grey literature for 1980 2017 regardless geographical locations languages. meta-analyzed estimates from original articles by: (a) or narrow diagnostic criteria, (b) time-frame, (c) without covariate adjustments. Over 43 000 unique studies were identified through electronic searches, which 391 selected full-text review. Finally, 171 eligible inclusion, including 53 additional snowball searching. In general, variations in diagnosis type, temporal order, use adjustments, there substantial disorders. Based entire 90 separate meta-analyses, median OR 6.1 (range 1.5–18.7). Of estimates, all above 1, 87 significantly greater than 1 (i.e., 95% confidence intervals did not include 1). Fourteen pooled had ORs 10. This systematic review found robust broadly defined Clinicians should be vigilant prompt identification treatment this common type comorbidity.

Язык: Английский

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Transcriptomic organization of the human brain in post-traumatic stress disorder

Nature Neuroscience, Год журнала: 2020, Номер 24(1), С. 24 - 33

Опубликована: Дек. 21, 2020

Язык: Английский

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