Advanced Engineering Materials,
Год журнала:
2023,
Номер
25(21)
Опубликована: Авг. 29, 2023
Stimuli‐responsive
polymers
(SRPs)
are
special
types
of
soft
materials,
which
have
been
extensively
used
for
developing
flexible
actuators,
robots,
wearable
devices,
sensors,
self‐expanding
structures,
and
biomedical
thanks
to
their
ability
change
shapes
functional
properties
in
response
external
stimuli
including
light,
humidity,
heat,
pH,
electric
field,
solvent,
magnetic
field
or
combinations
two
more
these
stimuli.
In
recent
years,
additive
manufacturing
(AM)
aka
3D
printing
technology
SRPs,
also
known
as
4D
printing,
has
gained
phenomenal
attention
different
engineering
fields,
its
unique
develop
complex,
personalized,
innovative
undergo
twisting,
elongating,
swelling,
rolling,
shrinking,
bending,
spiraling,
other
complex
morphological
transformations.
Herein,
an
effort
made
provide
insightful
information
about
the
AM
techniques,
type
applications
including,
but
not
limited
tissue
engineering,
bionics,
construction,
smart
textiles.
This
article
incorporates
current
challenges
prospects,
hoping
basis
utilization
this
fields.
It
is
expected
that
amalgamation
with
SRPs
would
unparalleled
advantages
arenas.
ACS Nano,
Год журнала:
2021,
Номер
15(2), С. 2068 - 2098
Опубликована: Фев. 8, 2021
Materials
that
respond
to
endogenous
stimuli
are
being
leveraged
enhance
spatiotemporal
control
in
a
range
of
biomedical
applications
from
drug
delivery
diagnostic
tools.
The
design
materials
undergo
morphological
or
chemical
changes
response
specific
biological
cues
pathologies
will
be
an
important
area
research
for
improving
efficacies
existing
therapies
and
imaging
agents,
while
also
promising
developing
personalized
theranostic
systems.
Internal
stimuli-responsive
systems
can
engineered
across
length
scales
nanometers
macroscopic
signals
such
as
enzymes,
pH,
glucose,
ATP,
hypoxia,
redox
signals,
nucleic
acids
by
incorporating
synthetic
bio-inspired
moieties
natural
building
blocks.
This
Review
summarize
mechanisms
fabrication
strategies
used
internal
with
focus
on
broad
pathologies,
including
cancer,
diabetes,
vascular
disorders,
inflammation,
microbial
infections.
We
discuss
observed
challenges,
future
directions,
clinical
translation
aspects
these
responsive
materials.
Pharmaceutics,
Год журнала:
2020,
Номер
12(9), С. 837 - 837
Опубликована: Сен. 1, 2020
Nanotechnologies
have
attracted
increasing
attention
in
their
application
medicine,
especially
the
development
of
new
drug
delivery
systems.
With
help
nano-sized
carriers,
drugs
can
reach
specific
diseased
areas,
prolonging
therapeutic
efficacy
while
decreasing
undesired
side-effects.
In
addition,
recent
nanotechnological
advances,
such
as
surface
stabilization
and
stimuli-responsive
functionalization
also
significantly
improved
targeting
capacity
nanocarrier
assisted
system.
this
review,
we
evaluate
advances
different
nanocarriers
applications
therapeutics
delivery.
Carriers
are
equally
important
as
drugs.
They
can
substantially
improve
bioavailability
of
cargos
and
safeguard
healthy
cells
from
toxic
effects
certain
therapeutics.
Recently,
polymeric
nanocarriers
(PNCs)
have
achieved
significant
success
in
delivering
drugs
not
only
to
but
also
subcellular
organelles.
Variety
natural
sources,
availability
different
synthetic
routes,
versatile
molecular
architectures,
exploitable
physicochemical
properties,
biocompatibility,
biodegradability
presented
polymers
one
the
most
desired
materials
for
nanocarrier
design.
Recent
innovative
concepts
advances
PNC-associated
nanotechnology
providing
unprecedented
opportunities
engineer
their
functions.
The
efficiency
therapeutic
loading
has
got
considerably
increased.
Structural
design-based
varieties
PNCs
widely
employed
delivery
small
molecules
genes,
proteins.
gained
ever-increasing
attention
certainly
paves
way
develop
advanced
nanomedicines.
This
article
presents
a
comprehensive
investigation
structural
influences
properties
on
drug
profiles
with
perspectives
highlighting
inevitability
incorporating
both
multi-stimuli-responsive
multi-drug
single
carrier
design
intelligent
new
emerging
research
directions
this
rapidly
developing
area.
Abstract
Until
now,
enormous
smart
materials
have
been
engineered
with
endogenous
stimulators
such
as
pH,
reactive
oxygen
species,
glutathione,
hypoxia
and
enzyme,
or
exogenous
temperature,
light,
ultrasound,
radiation,
magnetic
field
in
drug
delivery.
As
footstone
of
stimuli‐responsive
nanocarriers,
endogenous/exogenous
responsive
possess
many
properties,
responding
ability
to
specific
triggers,
controlled
release,
long
blood
circulation,
increased
tumor
accumulation,
“ON‐OFF”
switch
activities,
enhanced
diagnostic
accuracy,
therapeutic
efficacy.
Smart
attracted
considerable
attention
because
they
provide
likelihood
strategy
for
individualized
comprehensive
therapy.
In
this
review,
significant
research
achievements
different
triggers
including
their
synthesis
formulation
mechanism,
applications,
multiple
functions
are
summarized
discussed
separately.
We
primarily
focus
on
the
studies
past
few
years
(2017‐2020).
The
current
situation
remaining
challenges
stimuli‐sensitive
materials‐based
nanocarriers
clinical
translation
rationally
at
end.
It
is
hope
that
timely
overall
review
would
some
helpful
information
researchers
field.
Polymers,
Год журнала:
2023,
Номер
15(5), С. 1123 - 1123
Опубликована: Фев. 23, 2023
In
the
last
few
decades,
several
natural
bioactive
agents
have
been
widely
utilized
in
treatment
and
prevention
of
many
diseases
owing
to
their
unique
versatile
therapeutic
effects,
including
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
action.
However,
poor
aqueous
solubility,
bioavailability,
low
GIT
stability,
extensive
metabolism
as
well
short
duration
action
are
most
shortfalls
hampering
biomedical/pharmaceutical
applications.
Different
drug
delivery
platforms
developed
this
regard,
a
captivating
tool
has
fabrication
nanocarriers.
particular,
polymeric
nanoparticles
were
reported
offer
proficient
various
with
good
entrapment
potential
an
efficiently
controlled
release,
improved
fascinating
efficacy.
addition,
surface
decoration
polymer
functionalization
opened
door
improving
characteristics
alleviating
toxicity.
Herein,
review
state
knowledge
on
loaded
is
presented.
The
focuses
frequently
used
materials
corresponding
methods
fabrication,
needs
such
systems
for
agents,
literature,
role
functionalization,
hybrid
systems,
stimuli-responsive
overcoming
system
drawbacks.
This
exploration
may
thorough
idea
viewing
candidate
challenges
combating
tools
overcome
any
hurdles.
Polymers,
Год журнала:
2022,
Номер
14(5), С. 936 - 936
Опубликована: Фев. 26, 2022
A
number
of
promising
nano-sized
particles
(nanoparticles)
have
been
developed
to
conquer
the
limitations
conventional
chemotherapy.
One
most
methods
is
stimuli-responsive
nanoparticles
because
they
enable
safe
delivery
drugs
while
controlling
their
release
at
tumor
sites.
Different
intrinsic
and
extrinsic
stimuli
can
be
used
trigger
drug
such
as
temperature,
redox,
ultrasound,
magnetic
field,
pH.
The
intracellular
pH
solid
tumors
maintained
below
extracellular
Thus,
pH-sensitive
are
highly
efficient
in
delivering
compared
nanoparticles.
This
review
provides
a
survey
different
strategies
develop
cancer
therapy.
