Foods,
Год журнала:
2024,
Номер
13(24), С. 4131 - 4131
Опубликована: Дек. 20, 2024
Though
ubiquitous
in
nature,
polyphenols
gained
scientific
prominence
only
after
the
pioneering
work
of
researchers
like
E.
Fischer
and
K.
Freudenberg,
who
demonstrated
their
potential
beyond
traditional
applications,
such
as
leather
industry.
Today,
these
bioactive
compounds
are
recognized
for
diverse
therapeutic
roles,
including
use
adjuvants
cancer
treatment,
prevention,
anti-inflammatory
antioxidant
properties.
Additionally,
have
benefits
managing
obesity,
cardiovascular
diseases,
neuromodulation.
Their
synthesis
is
influenced
by
environmental
genetic
factors,
with
concentrations
varying
based
on
intensity
variables,
well
stage
ripening.
This
review
provides
a
comprehensive
overview
polyphenols,
covering
classification,
chemical
structures,
bioavailability.
The
mechanisms
influencing
bioavailability,
bioaccessibility,
bioactivity
explored
detail,
alongside
an
introduction
to
effects
associated
metabolic
pathways.
Specific
examples,
bioavailability
coffee
various
types
onions,
analyzed.
Despite
promising
biological
activities,
significant
limitation
lies
inherently
low
oral
However,
systemic
circulation
by-products
formed
during
digestion
present
exciting
opportunities
further
research
application.
ACS Omega,
Год журнала:
2023,
Номер
8(24), С. 21391 - 21409
Опубликована: Июнь 7, 2023
Biofilm-associated
infections
have
emerged
as
a
significant
public
health
challenge
due
to
their
persistent
nature
and
increased
resistance
conventional
treatment
methods.
The
indiscriminate
usage
of
antibiotics
has
made
us
susceptible
range
multidrug-resistant
pathogens.
These
pathogens
show
reduced
susceptibility
intracellular
survival.
However,
current
methods
for
treating
biofilms,
such
smart
materials
targeted
drug
delivery
systems,
not
been
found
effective
in
preventing
biofilm
formation.
To
address
this
challenge,
nanotechnology
provided
innovative
solutions
formation
by
clinically
relevant
Recent
advances
nanotechnological
strategies,
including
metallic
nanoparticles,
functionalized
dendrimers,
polymeric
cyclodextrin-based
delivery,
solid
lipid
polymer
conjugates,
liposomes,
may
provide
valuable
technological
against
infectious
diseases.
Therefore,
it
is
imperative
conduct
comprehensive
review
summarize
the
recent
advancements
limitations
advanced
nanotechnologies.
present
Review
encompasses
summary
agents,
mechanisms
that
lead
formation,
impact
on
human
health.
In
nutshell,
offers
survey
managing
infections.
A
detailed
presentation
how
these
strategies
improve
control
prevent
key
objective
mechanisms,
applications,
prospects
nanotechnologies
better
understanding
Molecules,
Год журнала:
2024,
Номер
29(15), С. 3482 - 3482
Опубликована: Июль 25, 2024
Nanoparticles
are
structures
that
possess
unique
properties
with
high
surface
area-to-volume
ratio.
Their
small
size,
up
to
100
nm,
and
potential
for
modifications
have
enabled
their
use
in
a
wide
range
of
applications.
Various
factors
influence
the
applications
NPs,
including
synthesis
method
physical
attributes
such
as
size
shape.
Additionally,
materials
used
NPs
primary
determinants
application.
Based
on
chosen
material,
generally
classified
into
three
categories:
organic,
inorganic,
carbon-based.
These
categories
include
variety
materials,
proteins,
polymers,
metal
ions,
lipids
derivatives,
magnetic
minerals,
so
on.
Each
material
possesses
activity
application
NPs.
Consequently,
certain
typically
particular
areas
because
they
higher
efficiency
along
tenable
toxicity.
Therefore,
classification
base
NP
hold
significant
importance
both
research
In
this
paper,
we
discuss
these
classifications,
exemplify
most
major
categorize
them
according
preferred
area
This
review
provides
an
overall
application,
Polymers,
Год журнала:
2024,
Номер
16(17), С. 2536 - 2536
Опубликована: Сен. 7, 2024
In
the
last
few
decades,
there
has
been
a
growing
interest
in
use
of
biodegradable
polymeric
nanoparticles
(BPNPs)
as
carriers
for
various
therapeutic
agents
drug
delivery
systems.
BPNPs
have
potential
to
improve
efficacy
numerous
active
by
facilitating
targeted
desired
site
body.
Biodegradable
polymers
are
especially
promising
nanocarriers
substances
characterized
poor
solubility,
instability,
rapid
metabolism,
and
system
elimination.
Such
molecules
can
be
efficiently
encapsulated
subsequently
released
from
nanoparticles,
which
greatly
improves
their
stability
bioavailability.
Biopolymers
seem
most
suitable
candidates
used
platforms,
due
biocompatibility
biodegradability.
Other
unique
properties
include
low
cost,
flexibility,
stability,
minimal
side
effects,
toxicity,
good
entrapment
potential,
long-term
controlled
release.
An
overview
summarizing
research
results
years
field
successful
fabrication
loaded
with
is
provided.
The
possible
challenges
involving
nanoparticle
under
physiological
conditions
possibility
scaling
up
production
while
maintaining
quality,
well
future
possibilities
employing
BPNPs,
also
reviewed.
Nanomaterials,
Год журнала:
2024,
Номер
14(8), С. 672 - 672
Опубликована: Апрель 12, 2024
Curcumin,
an
organic
phenolic
molecule
that
is
extracted
from
the
rhizomes
of
Curcuma
longa
Linn,
has
undergone
extensive
evaluation
for
its
diverse
biological
activities
in
both
animals
and
humans.
Despite
favorable
characteristics,
curcumin
encounters
various
formulation
challenges
stability
issues
can
be
effectively
addressed
through
application
nanotechnology.
Nano-based
techniques
specifically
focused
on
enhancing
solubility,
bioavailability,
therapeutic
efficacy
while
mitigating
toxicity,
have
been
explored
curcumin.
This
review
systematically
presents
information
improvement
curcumin’s
beneficial
properties
when
incorporated,
either
individually
or
conjunction
with
other
drugs,
into
nanosystems
such
as
liposomes,
nanoemulsions,
polymeric
micelles,
dendrimers,
nanoparticles,
solid-lipid
nanostructured
lipid
carriers.
Additionally,
examines
ongoing
clinical
trials
recently
granted
patents,
offering
a
thorough
overview
dynamic
landscape
delivery.
Researchers
are
currently
exploring
nanocarriers
crucial
features
surface
modification,
substantial
loading
capacity,
biodegradability,
compatibility,
autonomous
targeting
specificity
selectivity.
Nevertheless,
utilization
delivery
still
initial
phases,
regulatory
approval
pending
persistent
safety
concerns
surrounding
their
use.
Polymers,
Год журнала:
2024,
Номер
16(6), С. 843 - 843
Опубликована: Март 19, 2024
Chemotherapy
together
with
surgery
and/or
radiotherapy
are
the
most
common
therapeutic
methods
for
treating
cancer.
However,
off-target
effects
of
chemotherapy
known
to
produce
side
and
dose-limiting
toxicities.
Novel
delivery
platforms
based
on
natural
synthetic
polymers
enhanced
pharmacokinetic
potential
treatment
cancer
have
grown
tremendously
over
past
10
years.
Polymers
can
facilitate
selective
targeting,
enhance
prolong
circulation,
improve
delivery,
provide
controlled
release
cargos
through
various
mechanisms,
including
physical
adsorption,
chemical
conjugation,
internal
loading.
Notably,
that
biodegradable,
biocompatible,
physicochemically
stable
considered
be
ideal
carriers.
This
biomimetic
bio-inspired
system
offers
a
bright
future
effective
drug
overcome
obstacles
encountered.
review
focuses
barriers
impact
success
as
well
recent
developments
improving
Frontiers in Nanotechnology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 21, 2024
Nanoparticles
are
attractive
therapeutic
tools
due
to
their
distinctive
characteristics,
including
more
accurate
drug
delivery,
improved
bioavailability,
and
enhanced
targeted
therapy.
This
review
offers
a
comprehensive
analysis
of
the
potentials
cutting-edge
nanoparticles
as
demonstrated
in
human
clinical
trials,
based
on
empirical
evidence.
Through
systematic
searches
major
scientific
databases,
relevant
studies
published
up
March
2024
were
included,
focusing
trials
utilizing
advanced
for
purposes.
The
discusses
diverse
applications
oncology,
infectious
diseases,
neurology,
other
medical
fields.
Additionally,
it
scrutinizes
safety
profiles,
efficacy
outcomes,
challenges
associated
with
nanoparticle-based
therapies.
findings
underscore
significant
progress
translating
nanoparticle
research
into
practice
highlight
potential
these
innovative
platforms
revolutionize
treatments.
contributes
valuable
insights
growing
field
therapeutics,
fostering
deeper
understanding
implications
practice.
Pharmaceutics,
Год журнала:
2023,
Номер
16(1), С. 58 - 58
Опубликована: Дек. 29, 2023
Alzheimer's
disease,
a
progressive
neurodegenerative
condition,
is
characterized
by
gradual
decline
in
cognitive
functions.
Current
treatment
approaches
primarily
involve
the
administration
of
medications
through
oral,
parenteral,
and
transdermal
routes,
aiming
to
improve
function
alleviate
symptoms.
However,
these
treatments
face
limitations,
such
as
low
bioavailability
inadequate
permeation.
Alternative
invasive
methods,
while
explored,
often
entail
discomfort
require
specialized
assistance.
Therefore,
development
non-invasive
efficient
delivery
system
crucial.
Intranasal
has
emerged
potential
solution,
although
it
constrained
unique
conditions
nasal
cavity.
An
innovative
approach
involves
use
nano-carriers
based
on
nanotechnology
for
intranasal
delivery.
This
strategy
overcome
current
limitations
providing
enhanced
bioavailability,
improved
permeation,
effective
traversal
blood-brain
barrier,
extended
retention
within
body,
precise
targeting
brain.
The
comprehensive
review
focuses
advancements
designing
various
types
nano-carriers,
including
polymeric
nanoparticles,
metal
lipid
liposomes,
nanoemulsions,
Quantum
dots,
dendrimers.
These
are
specifically
tailored
therapeutic
agents
aimed
at
combatting
disease.
In
summary,
utilization
systems
show
significant
surmounting
constraints
disease
strategies.
Nevertheless,
essential
acknowledge
regulatory
well
toxicity
concerns
associated
with
this
route;
meticulous
consideration
required
when
engineering
carrier.
underscores
revolutionize
management
highlights
importance
addressing
considerations
safe
implementations.
Embracing
could
lead
substantial
field
treatment.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 836 - 836
Опубликована: Июль 11, 2024
Polyphenols
are
natural
bioactives
occurring
in
medicinal
and
aromatic
plants
food
beverages
of
plant
origin.
Compared
with
conventional
therapies,
plant-derived
phytochemicals
more
affordable
accessible
have
no
toxic
side
effects.
Thus,
pharmaceutical
research
is
increasingly
inclined
to
discover
study
new
innovative
molecules
for
the
treatment
several
chronic
human
diseases,
like
type
2
diabetes
mellitus
(T2DM)
osteoporosis.
These
pathological
conditions
characterized
by
a
inflammatory
state
persistent
oxidative
stress,
which
interconnected
lead
development
worsening
these
two
health
disorders.
Oral
nano
delivery
strategies
been
used
improve
bioavailability
polyphenols
allow
exert
their
antioxidant,
anti-inflammatory,
anti-diabetic,
pro-osteogenic
biological
activities
vivo
experimental
models
patients.
commonly
formulations
nutraceuticals,
can
counteract
detrimental
effects
T2DM
osteoporosis
pathologies.
This
review
describes
that
protective
against
through
modulation
specific
molecular
markers
pathways.
could
be
as
adjuvants,
combination
synthetic
drugs,
future
develop
therapeutic
