Gut
microbes
play
a
crucial
role
in
regulating
the
tumor
microenvironment
(TME)
of
colorectal
cancer
(CRC).
Nevertheless,
deep
mechanism
between
microbiota-TME
interaction
has
not
been
well
explored.
In
this
study,
we
for
first
time
discovered
that
Lactobacillus
intestinalis
(L.
intestinalis)
effectively
suppressed
growth
both
AOM/DSS-induced
CRC
model
and
ApcMin/+
spontaneous
adenoma
model.
Our
investigation
revealed
L.
increased
infiltration
immune
cells,
particularly
dendritic
cells
(DC),
TME.
Mechanically,
tumor-derived
CCL5
induced
by
recruited
DC
chemotaxis
through
NOD1/NF-κB
signaling
pathway.
clinical
samples
datasets,
found
positive
correlation
intestinalis,
level,
DC-related
genes.
study
provided
new
strategy
microbial
intervention
deepened
understanding
modulated
gut
microbes.
Arabian Journal of Chemistry,
Год журнала:
2024,
Номер
17(4), С. 105650 - 105650
Опубликована: Янв. 24, 2024
Gold
nanoparticles
(AuNPs)
exhibit
promising
potential
as
medical
materials
due
to
their
high
biocompatibility,
tunable
size
and
shape,
excellent
drug
delivery
capabilities,
among
other
unique
physicochemical
properties.
Previous
studies
have
indicated
the
remarkable
anti-inflammatory
activity
of
ginsenoside
compound
K
(CK).
However,
relatively
low
bioavailability
CK
restricts
its
effective
action
within
biological
system.
Hence,
exploring
novel
methods
based
on
gold
emerges
a
strategy
overcome
these
challenges
in
application,
thereby
enhancing
therapeutic
effectiveness
CK.
Probiotic-mediated
AuNPs
were
synthesized
using
salt
lysates
Bifidobacterium
animalis
subsp.
lactis.
Then,
was
loaded
with
form
(Bifi-CKAuNPs).
The
Bifi-CKAuNPs
evaluated
vitro
RAW
264.7
cells
vivo
mice.
NF-κB/
mitogen-activated
protein
kinases
(MAPK)
pathway
investigated
mechanism
action.
In
experiments
showed
that
inhibited
activation
reactive
oxygen
species
reduced
expression
iNOS,
COX-2,
pro-inflammatory
cytokines
(IL-1β,
IL-6,
TNF-α)
cells.
significantly
inflammation
lung,
kidney,
liver
tissues
mice
without
toxicity.
mediated
through
inhibition
NF-κB/MAPK
signal
transduction,
which
is
well-known
critical
pathogenesis
inflammation.
We
successfully
characterized
Bifi-AuNPs,
demonstrating
potent
both
vivo.
Our
results
might
play
key
role
Bifi-CKAuNPs.
These
findings
underscored
significant
platform
for
therapy.
observed
efficacy
cellular
animal
models,
along
insights
into
underlying
molecular
pathways,
positions
valuable
candidate
advancing
strategies
realm
management.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2237 - 2237
Опубликована: Фев. 13, 2024
In
recent
years,
the
relationship
between
microbiota
and
various
aspects
of
health
has
become
a
focal
point
scientific
investigation.
Although
most
studied
concern
gastrointestinal
tract,
recently,
interest
also
been
extended
to
other
body
districts.
Female
genital
tract
dysbiosis
its
possible
impact
on
pathologies
such
as
endometriosis,
polycystic
ovary
syndrome
(PCOS),
pelvic
inflammatory
disease
(PID),
gynecological
cancers
have
unveiled.
The
incursion
pathogenic
microbes
alters
ecological
equilibrium
vagina,
triggering
inflammation
compromising
immune
defense,
potentially
fostering
an
environment
conducive
cancer
development.
common
types
include
cervical,
endometrial,
ovarian
cancer,
which
occur
in
women
any
age
but
especially
postmenopausal
women.
Several
studies
highlighted
that
low
presence
lactobacilli
at
vaginal
level,
consequently,
related
areas
(such
endometrium
ovary),
correlates
with
higher
risk
pathology
likely
contributes
increased
incidence
worse
prognosis
cancers.
complex
interplay
microbial
communities
development,
progression,
treatment
gynecologic
malignancies
is
burgeoning
field
not
yet
fully
understood.
intricate
crosstalk
gut
systemic
introduces
new
dimension
our
understanding
objective
this
review
focus
attention
association
provide
detailed
knowledge
for
future
diagnostic
therapeutic
strategies.
Gut
microbes
play
a
crucial
role
in
regulating
the
tumor
microenvironment
(TME)
of
colorectal
cancer
(CRC).
Nevertheless,
deep
mechanism
between
microbiota-TME
interaction
has
not
been
well
explored.
In
this
study,
we
for
first
time
discovered
that
Lactobacillus
intestinalis
(L.
intestinalis)
effectively
suppressed
growth
both
AOM/DSS-induced
CRC
model
and
ApcMin/+
spontaneous
adenoma
model.
Our
investigation
revealed
L.
increased
infiltration
immune
cells,
particularly
dendritic
cells
(DC),
TME.
Mechanically,
tumor-derived
CCL5
induced
by
recruited
DC
chemotaxis
through
NOD1/NF-κB
signaling
pathway.
clinical
samples
datasets,
found
positive
correlation
intestinalis,
level,
DC-related
genes.
study
provided
new
strategy
microbial
intervention
deepened
understanding
modulated
gut
microbes.
