Novel modified probiotic gold nanoparticles loaded with ginsenoside CK exerts an anti-inflammation effect via NF-κB/MAPK signaling pathways

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(4), P. 105650 - 105650

Published: Jan. 24, 2024

Gold nanoparticles (AuNPs) exhibit promising potential as medical materials due to their high biocompatibility, tunable size and shape, excellent drug delivery capabilities, among other unique physicochemical properties. Previous studies have indicated the remarkable anti-inflammatory activity of ginsenoside compound K (CK). However, relatively low bioavailability CK restricts its effective action within biological system. Hence, exploring novel methods based on gold emerges a strategy overcome these challenges in application, thereby enhancing therapeutic effectiveness CK. Probiotic-mediated AuNPs were synthesized using salt lysates Bifidobacterium animalis subsp. lactis. Then, was loaded with form (Bifi-CKAuNPs). The Bifi-CKAuNPs evaluated vitro RAW 264.7 cells vivo mice. NF-κB/ mitogen-activated protein kinases (MAPK) pathway investigated mechanism action. In experiments showed that inhibited activation reactive oxygen species reduced expression iNOS, COX-2, pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) cells. significantly inflammation lung, kidney, liver tissues mice without toxicity. mediated through inhibition NF-κB/MAPK signal transduction, which is well-known critical pathogenesis inflammation. We successfully characterized Bifi-AuNPs, demonstrating potent both vivo. Our results might play key role Bifi-CKAuNPs. These findings underscored significant platform for therapy. observed efficacy cellular animal models, along insights into underlying molecular pathways, positions valuable candidate advancing strategies realm management.

Language: Английский

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Modulating the tumoral SPARC content to enhance albumin-based drug delivery for cancer therapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 596 - 610

Published: Jan. 13, 2024

Language: Английский

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Gynecological Cancers and Microbiota Dynamics: Insights into Pathogenesis and Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2237 - 2237

Published: Feb. 13, 2024

In recent years, the relationship between microbiota and various aspects of health has become a focal point scientific investigation. Although most studied concern gastrointestinal tract, recently, interest also been extended to other body districts. Female genital tract dysbiosis its possible impact on pathologies such as endometriosis, polycystic ovary syndrome (PCOS), pelvic inflammatory disease (PID), gynecological cancers have unveiled. The incursion pathogenic microbes alters ecological equilibrium vagina, triggering inflammation compromising immune defense, potentially fostering an environment conducive cancer development. common types include cervical, endometrial, ovarian cancer, which occur in women any age but especially postmenopausal women. Several studies highlighted that low presence lactobacilli at vaginal level, consequently, related areas (such endometrium ovary), correlates with higher risk pathology likely contributes increased incidence worse prognosis cancers. complex interplay microbial communities development, progression, treatment gynecologic malignancies is burgeoning field not yet fully understood. intricate crosstalk gut systemic introduces new dimension our understanding objective this review focus attention association provide detailed knowledge for future diagnostic therapeutic strategies.

Language: Английский

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Metal-ion-chelating phenylalanine nanostructures reverse immune dysfunction and sensitize breast tumour to immune checkpoint blockade

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(12), P. 1903 - 1913

Published: Aug. 26, 2024

Language: Английский

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Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 8, 2025

Gut microbes play a crucial role in regulating the tumor microenvironment (TME) of colorectal cancer (CRC). Nevertheless, deep mechanism between microbiota-TME interaction has not been well explored. In this study, we for first time discovered that Lactobacillus intestinalis (L. intestinalis) effectively suppressed growth both AOM/DSS-induced CRC model and ApcMin/+ spontaneous adenoma model. Our investigation revealed L. increased infiltration immune cells, particularly dendritic cells (DC), TME. Mechanically, tumor-derived CCL5 induced by recruited DC chemotaxis through NOD1/NF-κB signaling pathway. clinical samples datasets, found positive correlation intestinalis, level, DC-related genes. study provided new strategy microbial intervention deepened understanding modulated gut microbes.

Language: Английский

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