The role of CXCL family members in different diseases

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Июль 1, 2023

Chemokines are a large family mediating lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member this family, CXC subfamily possesses the same ability. chemokines can recruit migrate different categories immune cells, regulate tumor's pathological like proliferation, invasion metastasis, activate angiogenesis, etc. Due to these characteristics, CXCL is extensively closely associated with tumors inflammatory diseases. studies becoming more intensive, CXCLs' concrete roles better described, therapeutic applications biomarkers targets also deeply explained. In review, role members in various diseases summarized.

Язык: Английский

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Role of chemokine systems in cancer and inflammatory diseases

MedComm, Год журнала: 2022, Номер 3(2)

Опубликована: Июнь 1, 2022

Abstract Chemokines are a large family of small secreted proteins that have fundamental roles in organ development, normal physiology, and immune responses upon binding to their corresponding receptors. The primary functions chemokines coordinate recruit cells from tissues participate regulating interactions between cells. In addition the generally recognized antimicrobial immunity, chemokine/chemokine receptor axis also exerts tumorigenic function many different cancer models is involved formation immunosuppressive protective tumor microenvironment (TME), making them potential prognostic markers for various hematologic solid tumors. fact, apart its vital role tumors, almost all inflammatory diseases involve receptors one way or another. Modulating expression and/or on provides basis exploitation new drugs clinical evaluation treatment related diseases. Here, we summarize recent advances chemokine systems protumor antitumor discuss prevailing understanding how system operates this review, emphatically highlight complexity explore guide

Язык: Английский

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Traumatic inflammatory response: pathophysiological role and clinical value of cytokines

European Journal of Trauma and Emergency Surgery, Год журнала: 2023, Номер 50(4), С. 1313 - 1330

Опубликована: Дек. 27, 2023

Severe trauma is an intractable problem in healthcare. Patients have a widespread immune system response that complex and vital to survival. Excessive inflammatory the main cause of poor prognosis therapeutic effect medications patients. Cytokines are signaling proteins play critical roles body's injuries, which could amplify or suppress responses. Studies demonstrated cytokines closely related severity injuries patients help present cytokine-based diagnosis treatment plans for In this review, we introduce pathophysiological mechanisms traumatic role Furthermore, discuss potential therapy post-traumatic response, although further clarification elucidate underlying following warranted.

Язык: Английский

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Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms

Journal of Functional Foods, Год журнала: 2025, Номер 125, С. 106690 - 106690

Опубликована: Янв. 28, 2025

Язык: Английский

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Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Июнь 15, 2024

Ulcerative colitis (UC) is a significant inflammatory bowel disease caused by an abnormal immune response to gut microbes. However, there are still gaps in our understanding of how and metabolic changes specifically contribute this disease. Our research aims address gap examining mouse colons after inducing ulcerative colitis-like symptoms. Employing single-cell RNA-seq 16 s rRNA amplicon sequencing analyze distinct cell clusters microbiomes the colon at different time points induction with dextran sodium sulfate. We observe reduction epithelial populations during acute colitis, indicating tissue damage, partial recovery observed chronic inflammation. Analyses cell-cell interactions demonstrate shifts networking patterns among types progression. Notably, macrophage phenotypes exhibit diversity, pronounced polarization towards pro-inflammatory M1 phenotype conditions, suggesting role heterogeneity severity. Increased expression Nampt NOX2 complex subunits UC macrophages contributes processes. The microbiome exhibits reduced taxonomic diversity compared healthy conditions UC. study also highlights T differentiation context dysbiosis its implications progression, emphasizing need for targeted interventions modulate balance colitis.

Язык: Английский

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The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 8026 - 8026

Опубликована: Апрель 28, 2023

Neuroinflammation plays a fundamental role in the development and progression of neurodegenerative diseases. It could therefore be said that neuroinflammation pathologies is not consequence but cause them represent therapeutic target neuronal degeneration. CX3CL1 several proteases (ADAMs/MMPs) are strongly involved inflammatory pathways these with multiple effects. On one hand, ADAMs have neuroprotective anti-apoptotic effects; on other they cytokines chemokines, thus causing processes and, consequently, neurodegeneration. itself cytokine substrate for ADAM, ADAM17, which cleaves releases it soluble isoform (sCX3CL1). CX3CL1, as an adhesion molecule, inhibiting pro-inflammatory response central nervous system (CNS) shows effects by binding its membrane receptor (CX3CR1) present into microglia cells maintaining quiescent state; sCX3CL1 seems to promote In this review, dual roles ADAMs/MMPs different diseases, such Alzheimer's disease (AD), Parkinson's (PD), Huntington's (MH), sclerosis (MS), investigated.

Язык: Английский

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Navigating the Cytokine Storm: A Comprehensive Review of Chemokines and Cytokines in Sepsis

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Фев. 15, 2024

This comprehensive review thoroughly explores the intricate relationship between chemokines, cytokines, and cytokine storm in sepsis, offering a nuanced understanding of molecular mechanisms underpinning this life-threatening syndrome. Beginning with examining sepsis stages immune response dynamics, emphasizes dysregulation leading to storm, where pro- anti-inflammatory cytokines disrupt delicate equilibrium. Delving into discussion encompasses subfamilies, receptors, functions, highlighting their critical roles cell migration activation during sepsis. The implications for clinical practice are substantial, suggesting avenues targeted diagnostics therapeutic interventions. identifies areas future research, including search novel biomarkers, deeper insights regulation, pursuit personalized medicine approaches. exploration aims guide clinicians, researchers, policymakers navigating complexities fostering foundation transformative advancements managing formidable challenge.

Язык: Английский

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The Impact of Immunomodulatory Components Used in Clinical Nutrition—A Narrative Review

Nutrients, Год журнала: 2025, Номер 17(5), С. 752 - 752

Опубликована: Фев. 21, 2025

Background: Malnutrition is a clinical condition that leads to unfavourable changes in health. It affects 35–55% of hospitalized patients, and the case cancer, this prevalence rises 40–90% patients. Screening nutritional status essential for preventing undernutrition, which crucial as its treatment. Undernutrition patients after severe injuries significantly increases catabolic changes. Cytokines hormones, such epinephrine, glucagon, cortisol, are released, can increase energy expenditure by 50%. Properly conducted treatment aims maintain or improve whose nutrition with natural diet insufficient, moreover, some cases, underlying disease. Methods: This study narrative review focused on immunonutrition. The search source articles, mainly from last 10 years, was PubMed Google Schoolar databases, well printed books. key words used were “malnutrition”, “inflammation”, “clinical nutrition”, “immunomodulatory components”, “nutritional assessment”, “enteral “parenteral their combinations. Results: Providing substances omega-3 fatty acids, glutamine, arginine, nucleotides, antioxidants, prebiotic fiber has beneficial impact immunological anti-inflammatory pathways. above-mentioned ingredients may inhibit secretion pro-inflammatory cytokines, activate stimulate immune cells, have effect allergic diseases, respiratory infections, wound healing. Conslusion: Immunonutrition be administrated via oral, enteral, parenteral routes. highlight importance proper relationship between inflammation malnutrition creates vicious cycle, where one negatively other due increased metabolic demand, loss appetite, weakened system, gut dysbiosis.

Язык: Английский

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Fibroblast-derived versican exacerbates periodontitis progression by regulating macrophage migration and inflammatory cytokine secretion

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111755 - 111755

Опубликована: Март 1, 2025

Язык: Английский

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Biological and Clinical Aspects of Metastatic Spinal Tumors

Cancers, Год журнала: 2022, Номер 14(19), С. 4599 - 4599

Опубликована: Сен. 22, 2022

Spine metastases are a common life-threatening complication of advanced-stage malignancies and often result in poor prognosis. Symptomatic spine develop the course about 10% malignant neoplasms. Therefore, it is essential for contemporary medicine to understand metastatic processes order find appropriate, targeted therapeutic options. Thanks continuous research, there appears more detailed knowledge cancer metastasis, but these transformations extremely complicated, e.g., due complexity reactions, variety places where they occur, or participation both tumor cells host transitions. The right target points metastasis mechanisms still being researched; that will help us proper diagnosis as well finding treatment. In this literature review, we described current molecular pathways biomarkers engaged involving spine. We also presented bone-targeted treatment emerging therapies targeting discussed mechanisms.

Язык: Английский

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