Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

ACS Applied Bio Materials, Год журнала: 2022, Номер 5(3), С. 971 - 1012

Опубликована: Фев. 28, 2022

Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup resistances. However, significant technological advancements have been made in terms superior modes delivery over the last few decades. Technical capability analyzing molecular mechanisms tumor biology, nanotechnology─particularly development biocompatible nanoparticles, surface modification techniques, microelectronics, material sciences─has increased. As a result, number nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency developed. This particular maneuver enables introduction substance body by controlling rate, time, place is defined system (NDDS). Because their versatility ability incorporate features water solubility, stability, biocompatibility, degradability, reverse resistance, they attracted interest scientific community, general, nanotechnologists well biomedical scientists. To keep pace rapid advancement nanotechnology, technical aspects recent NDDSs prospects need be reported coherently. address these ongoing issues, this review article provides an overview different lipids, polymers, inorganic nanoparticles. In addition, also reports challenges current points out prospective research directions nanocarriers. From our focused review, we conclude still now most advanced potent field application lipid-based, while significantly potential fields include polymer-based NDDSs. despite promises, remain practical implementations dosage caution should exercised regarding biocompatibility materials. Considering objectively, on will particularly small-to-large scale industrial researchers academicians expertise delivery, research, nanotechnology.

Язык: Английский

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Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Nano Select, Год журнала: 2021, Номер 3(4), С. 792 - 828

Опубликована: Окт. 13, 2021

Abstract Gold nanoparticles (GNPs) have been extensively used in various applications ranging from environmental detection to biomedical applications. Due their unique characteristics such as tunable surface properties well plasmon resonance (SPR), GNPs garnered attention exclusively therapy and diagnostics. Their ease of synthesis compatibility with functionalizing ligands has made them efficient a robust platform. flexibility functionalization, profoundly cancer treatment as, antiviral, antibacterial agents. In addition, owing possessing optical properties, utilized molecular imaging contrast agent. This article discusses highlights special that exploited recent years improve research field nuclear medicine, agent, vaccine development, medical implant, diagnostics, biosensing, lab‐on‐chip Moreover, size dependent biocompatibility, biodistribution, excreation was discussed details for vivo At the forefront modern theraputic technology, based antiviral agents great potential which is also highlighted briefly this article. current state ongoing clinical trials challenges associated regulatory approval are explored. Lastly, sheds light on findings toxicity prospects future direct research.

Язык: Английский

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Magnetic Nanoparticles: A Review on Synthesis, Characterization, Functionalization, and Biomedical Applications

Small, Год журнала: 2023, Номер 20(5)

Опубликована: Сен. 21, 2023

Abstract Nowadays, magnetic nanoparticles (MNPs) are applied in numerous fields, especially biomedical applications. Since biofluidic samples and biological tissues nonmagnetic, negligible background signals can interfere with the from MNPs biosensing imaging In addition, be remotely controlled by which make it possible for separation targeted drug delivery. Furthermore, due to unique dynamic magnetizations of when subjected alternating also proposed as a key tool cancer treatment, an example is hyperthermia therapy. Due their distinct surface chemistry, good biocompatibility, inducible moments, material morphological structure design has attracted enormous interest variety scientific domains. Herein, thorough review chemical synthesis strategies MNPs, methodologies modify better physicochemical characterization techniques well some representative applications disease diagnosis treatment provided. Further portions go into diagnostic therapeutic uses composite core/shell structures deeper analysis MNP properties learn about potential

Язык: Английский

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Classification and properties of nanoparticles

Elsevier eBooks, Год журнала: 2022, Номер unknown, С. 15 - 54

Опубликована: Янв. 1, 2022

Язык: Английский

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Therapeutic applications of magnetic nanoparticles: recent advances

Materials Advances, Год журнала: 2022, Номер 3(20), С. 7425 - 7444

Опубликована: Янв. 1, 2022

Magnetic nanoparticles (MNPs) show tremendous possibilities in the field of biomedicine, especially as therapeutic agents for use over a prolonged duration.

Язык: Английский

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Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy

Pharmaceutics, Год журнала: 2022, Номер 14(5), С. 937 - 937

Опубликована: Апрель 26, 2022

Cancer is among the leading causes of mortality globally, with nearly 10 million deaths in 2020. The emergence nanotechnology has revolutionised treatment strategies medicine, rigorous research focusing on designing multi-functional nanoparticles (NPs) that are biocompatible, non-toxic, and target-specific. Iron-oxide-based NPs have been successfully employed theranostics as imaging agents drug delivery vehicles for anti-cancer treatment. Substituted iron-oxides (MFe2O4) emerged potential nanocarriers due to their unique attractive properties such size magnetic tunability, ease synthesis, manipulatable properties. Current explores use hyperthermia cancer therapy. Significantly, there considerations applying iron-oxide-based enhanced biocompatibility, biodegradability, colloidal stability, lowered toxicity, more efficient targeted delivery. This review covers therapy, recent advances ferrites. Methods synthesis cubic spinel ferrites requirements therapy discussed. highlights surface modifications, where functionalisation specific biomolecules can deliver better efficiency. Finally, challenges solutions summarised.

Язык: Английский

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Precision-engineered metal and metal-oxide nanoparticles for biomedical imaging and healthcare applications

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 332, С. 103263 - 103263

Опубликована: Июль 31, 2024

The growing field of nanotechnology has witnessed numerous advancements over the past few years, particularly in development engineered nanoparticles. Compared with bulk materials, metal nanoparticles possess more favorable properties, such as increased chemical activity and toxicity, owing to their smaller size larger surface area. Metal exhibit exceptional stability, specificity, sensitivity, effectiveness, making them highly useful biomedical field. are high demand nanotechnology, including Au, Ag, Pt, Cu, Zn, Co, Gd, Eu, Er. These particles excellent physicochemical amenable functionalization, non-corrosiveness, varying optical electronic properties based on shape. can be modified different targeting agents antibodies, liposomes, transferrin, folic acid, carbohydrates. Thus, hold great promise for various applications photoacoustic imaging, magnetic resonance computed tomography (CT), photothermal, photodynamic therapy (PDT). Despite potential, safety considerations, regulatory hurdles must addressed safe clinical applications. This review highlights nanoparticle engineering explores integration emerging technologies bioimaging, cancer therapeutics nanomedicine. By offering valuable insights, this comprehensive offers a deep understanding potential research.

Язык: Английский

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Magnetic nanosystem a tool for targeted delivery and diagnostic application: Current challenges and recent advancement

International Journal of Pharmaceutics X, Год журнала: 2024, Номер 7, С. 100231 - 100231

Опубликована: Янв. 23, 2024

Over the last two decades, researchers have paid more attention to magnetic nanosystems due their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, could also been used diagnosis treatment because of magnetic, optical, fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) quantum dots (QDs) are most widely prepared by a simple process. By surface modification, recently working on conjugating metals like silica, copper, gold with nanosystems. This hybridization modifies structural characteristics nanomaterials helps improve efficacy targeted drug gene delivery. various micelles, cubosomes, liposomes, polymeric is gaining interest nanometer size range nontoxic, biocompatible nature. they good injectability higher targeting ability accumulation at target site external field. present article discussed detail regarding structure, properties, interaction biological system, diagnostic

Язык: Английский

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Package delivered: folate receptor-mediated transporters in cancer therapy and diagnosis

Chemical Science, Год журнала: 2024, Номер 15(6), С. 1966 - 2006

Опубликована: Янв. 1, 2024

Neoplasias pose a significant threat to aging society, underscoring the urgent need overcome limitations of traditional chemotherapy through pioneering strategies. Targeted drug delivery is an evolving frontier in cancer therapy, aiming enhance treatment efficacy while mitigating undesirable side effects. One promising avenue utilizes cell membrane receptors like folate receptor guide transporters precisely malignant cells. Based on cellular as hallmark, targeted nanocarriers and small molecule-drug conjugates have been developed that comprise different (bio) chemistries and/or mechanical properties with individual advantages challenges. Such modern folic acid-conjugated stimuli-responsive provide systemic controlled release, enabling reduced dosages, circumvention resistance, diminished adverse Since transporters' structure-based

Язык: Английский

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The recent advances of copper(II)-β-cyclodextrin complex as a practical catalyst system for various organic conversions: A review

Journal of Organometallic Chemistry, Год журнала: 2025, Номер unknown, С. 123509 - 123509

Опубликована: Янв. 1, 2025

Язык: Английский

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