Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(27)
Опубликована: Июль 11, 2024
Abstract
Chronic
wounds
adversely
affect
the
quality
of
life.
Although
electrical
stimulation
has
been
utilized
to
treat
chronic
wounds,
there
are
still
limitations
practicing
it
due
complicated
power
system.
Herein,
an
electrostimulating
membrane
incorporated
with
electrospun
nanofiber
(M‐sheet)
diabetic
is
developed.
Through
screen
printing
method,
various
alternate
patterns
both
Zn
and
AgCl
on
a
polyurethane
substrate,
generating
redox‐mediated
fields
introduced.
The
antibacterial
ability
patterned
against
E.
coli
S.
aureus
confirmed.
Furthermore,
poly(vinyl
alcohol)
(PVA)/gelatin
fiber
into
enhance
biocompatibility
maintain
wet
condition
in
wound
environment.
M‐sheet
can
improve
cell
proliferation
migration
vitro
immune
regulatory
effect
by
inducing
polarization
macrophage
M2
phenotype.
Finally,
when
applied
skin
model,
displays
accelerated
healing
rate
enhances
re‐epithelialization,
collagen
synthesis,
angiogenesis.
It
suggests
that
simple
portable
system
for
spontaneous
generation
great
potential
be
used
practical
other
tissue
engineering
applications.
RSC Advances,
Год журнала:
2024,
Номер
14(5), С. 3359 - 3378
Опубликована: Янв. 1, 2024
Electrostatic
spinning
as
a
technique
for
producing
nanoscale
fibers
has
recently
attracted
increasing
attention
due
to
its
simplicity,
versatility,
and
loadability.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
A
dressing
patch
made
of
radially
oriented
poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
(PHBV)
nanofibers
was
successfully
manufactured
with
a
modified
electrospinning
strategy.
The
as-electrospun
PHBV
nanofiber
exhibited
uniform
and
bead-free
nanofibrous
morphology
innovative
arrangement,
which
demonstrated
to
possess
obviously
improved
mechanical
property,
increased
surface
hydrophilicity
enhanced
biological
properties
compared
the
control
traditionally
randomly
pattern.
Interestingly,
it
found
that
pattern
could
induce
cell
migration
from
periphery
center
along
in
rapid
manner.
To
further
improve
biofunction
patch,
berberine
(Beri,
an
isoquinoline
alkaloid)
two
different
concentrations
were
encapsulated
into
during
electrospinning,
present
sustained
drug
release
behavior
for
nearly
one
month.
Importantly,
addition
Beri
impart
excellent
anti-inflammatory
property
by
significantly
inhibiting
secretion
pro-inflammatory
factors
M1
macrophages,
also
showed
additive
influence
on
promoting
proliferation
human
dermal
fibroblasts
(HDFs),
as
well
growth
E.
coli,
S.
aureus
C.
albicans,
Beri-free
patch.
In
animal
studies,
electrospun
loading
high
content
accelerate
healing
process
diabetic
mouse
full-thickness
skin
wound
shortened
time
(100%
closure
rate
after
18
days’
treatment)
quality
(improved
collagen
deposition,
re-epithelialization
neovascularization
hair
follicles).
all,
this
study
reported
therapeutic
strategy
integrating
physical
cues
multiple
effective
treatment
hard-to-heal
wounds.
Pharmaceutics,
Год журнала:
2024,
Номер
16(3), С. 300 - 300
Опубликована: Фев. 21, 2024
Wounds,
which
are
becoming
more
common
as
a
result
of
traumas,
surgery,
burns,
and
chronic
illnesses
like
diabetes,
remain
critical
medical
problem.
Infectious
bacteria
impact
the
healing
process,
particularly
if
its
biofilm
(biological
films)
leads
to
prolonged
effect.
Nanomaterials
have
emerged
promising
candidates
in
field
wound
due
their
unique
properties
versatile
applications.
New
insights
into
interactions
between
nanomaterials
microenvironments
shed
light
on
mechanisms
underlying
therapeutic
effects.
However,
significantly
minimal
amount
research
has
been
carried
out
see
these
promote
process.
In
this
review,
we
provided
an
outline
various
types
that
studied
for
wounds
infection
prevention.
Overall,
utilization
holds
great
promise
continues
evolve,
providing
new
opportunities
development
effective
efficient
care
therapies.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 2660 - 2676
Опубликована: Май 9, 2024
Wound
healing,
particularly
for
chronic
wounds,
presents
a
considerable
difficulty
due
to
differences
in
biochemical
and
cellular
processes
that
occur
different
types
of
wounds.
Recent
technological
breakthroughs
have
notably
advanced
the
understanding
diagnostic
therapeutic
approaches
wound
healing.
The
evolution
care
has
seen
transition
from
traditional
textile
dressings
variety
alternatives,
including
self-healing
hydrogels,
hydrofibers,
foams,
hydrocolloids,
environment
responsive
dressings,
growth
factor-based
therapy,
bioengineered
skin
substitutes,
stem
cell
gene
therapy.
Technological
advancements,
such
as
3D
printing
electronic
(e-skin)
contribute
customization
Despite
these
effectively
managing
wounds
remains
challenging.
This
necessitates
development
treatments
consider
performance,
risk–benefit
balance,
cost-effectiveness.
review
discusses
innovative
strategies
healing
Incorporating
biomarkers
into
coupled
with
corresponding
biosensors
drug
delivery
formulations,
enables
theranostic
approach
treatment
Furthermore,
integrating
power
sources
user
interfaces
like
near-field
communication,
radio
frequency
identification,
Bluetooth
enhances
real-time
monitoring
on-demand
delivery.
It
also
provides
thorough
evaluation
advantages,
patient
compliance,
costs,
durability
emphasizing
smart
formulations
their
preparation
methods.
Pharmaceutics,
Год журнала:
2024,
Номер
16(1), С. 93 - 93
Опубликована: Янв. 10, 2024
Wounds
and
chronic
wounds
can
be
caused
by
bacterial
infections
lead
to
discomfort
in
patients.
To
solve
this
problem,
scientists
are
working
create
modern
wound
dressings
with
antibacterial
additives,
mainly
because
traditional
materials
cannot
meet
the
general
requirements
for
complex
promote
healing.
This
demand
is
met
material
engineering,
through
which
we
electrospun
dressings.
Electrospun
dressings,
as
well
those
based
on
hydrogels
incorporated
compounds,
these
requirements.
manuscript
reviews
recent
used
discussing
their
formation,
application,
functionalization.
The
focus
presenting
hydrogels.
In
contrast,
advancements
care
have
highlighted
potential
of
thermoresponsive
dynamic
These
contain
adaptable
polymers
that
offer
targeted
drug
delivery
show
promise
managing
various
types
while
addressing
infections.
way,
article
intended
serve
a
compendium
knowledge
researchers,
medical
practitioners,
biomaterials
engineers,
providing
up-to-date
information
state
art,
possibilities
innovative
solutions,
challenges
area
