Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2025, Номер unknown, С. 103619 - 103619
Опубликована: Июнь 1, 2025
Язык: Английский
Science, Год журнала: 2022, Номер 378(6618)
Опубликована: Окт. 27, 2022
Spermidine (SPD) delays age-related pathologies in various organisms. SPD supplementation overcame the impaired immunotherapy against tumors aged mice by increasing mitochondrial function and activating CD8+ T cells. Treatment of naïve cells with acutely enhanced fatty acid oxidation. conjugated to beads bound trifunctional protein (MTP). In MTP complex, synthesized purified from Escherichia coli, α β subunits strong affinity allosterically their enzymatic activities. cell-specific deletion subunit abolished enhancement programmed cell death 1 (PD-1) blockade SPD, indicating that is required for SPD-dependent activation.
Язык: Английский
Процитировано
123
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Март 14, 2023
Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.
Язык: Английский
Процитировано
85
Cells, Год журнала: 2022, Номер 11(4), С. 672 - 672
Опубликована: Фев. 15, 2022
Senescence is a complex cellular stress response that abolishes proliferative capacity and generates unique secretory pattern implicated in organismal aging age-related disease. How cell transitions to senescent state multifactorial often requires transcriptional regulation of multiple genes. Epigenetic alterations DNA chromatin are powerful regulators genome architecture gene expression, they play crucial role mediating the induction maintenance senescence. This review will highlight changes chromatin, methylation, histone establish maintain senescence, alongside specific epigenetic senescence-associated phenotype (SASP).
Язык: Английский
Процитировано
84
Nutrients, Год журнала: 2021, Номер 13(12), С. 4550 - 4550
Опубликована: Дек. 18, 2021
The role of the microbiome in human aging is important: directly impacts through gastrointestinal system. However, microbial impact on skin has yet to be fully understood. For example, cellular senescence an intrinsic process that been recently associated with imbalance. With age, cells become senescent response stress wherein they undergo irreversible growth arrest while maintaining high metabolic activity. An accumulation linked various and chronic pathologies due overexpression senescence-associated secretory phenotype (SASP) comprised proinflammatory cytokines, chemokines, factors, proteases, lipids extracellular matrix components. In particular, dermatological disorders may promoted by as a common site accumulation. gut microbiota influences disruption gut-skin axis secretion metabolites. Metabolomics can used identify quantify metabolites involved senescence. Moreover, novel anti-senescent therapeutics are warranted given poor safety profiles current pharmaceutical drugs. Probiotics prebiotics effective alternatives, considering relationship between healthy aging. further research composition under status needed develop immunomodulatory therapies.
Язык: Английский
Процитировано
84
Nutrients, Год журнала: 2021, Номер 13(10), С. 3420 - 3420
Опубликована: Сен. 28, 2021
The ketone bodies, especially β-hydroxybutyrate (β-HB), derive from fatty acid oxidation and alternatively serve as a fuel source for peripheral tissues including the brain, heart, skeletal muscle. β-HB is currently considered not solely an energy substrate maintaining metabolic homeostasis but also acts signaling molecule of modulating lipolysis, oxidative stress, neuroprotection. Besides, it serves epigenetic regulator in terms histone methylation, acetylation, β-hydroxybutyrylation to delay various age-related diseases. In addition, studies support endogenous administration or exogenous supplementation effective strategies induce state nutritional ketosis. purpose this review article provide overview metabolism its relationship application Future are needed reveal whether has potential adjunctive therapy aging.
Язык: Английский
Процитировано
79
PROTEOMICS, Год журнала: 2020, Номер 20(5-6)
Опубликована: Фев. 18, 2020
Abstract Aging biology is intimately associated with dysregulated metabolism, which one of the hallmarks aging. Aging‐related pathways such as mTOR and AMPK, are major targets anti‐aging interventions including rapamcyin, metformin, exercise, either directly regulate or intersect metabolic pathways. In this review, numerous candidate bio‐markers aging that have emerged using metabolomics outlined. Metabolomics studies also reveal not all metabolites created equally. A set core “hub” emerging central mediators The hub reviewed here nicotinamide adenine dinucleotide, reduced dinucleotide phosphate, α‐ketoglutarate, β‐hydroxybutyrate. These signaling epigenetic roles along their canonical co‐factors intermediates carbon metabolism. Together these suggest a role TCA cycle in dysregulation
Язык: Английский
Процитировано
77
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(9), С. 5026 - 5026
Опубликована: Май 10, 2021
Consuming a balanced, nutritious diet is important for maintaining health, especially as individuals age. Several studies suggest that consuming rich in antioxidants and anti-inflammatory components such those found fruits, nuts, vegetables, fish may reduce age-related cognitive decline the risk of developing various neurodegenerative diseases. Numerous have been published over last decade focusing on nutrition how this impacts health. The main objective current article to review data linking role with aging decline. Specifically, we discuss roles micronutrients macronutrients provide an overview gut microbiota-gut-brain axis impact brain function general processes particular during aging. We propose dietary interventions designed optimize levels macro maximize functioning can be therapeutic value improving functioning, particularly
Язык: Английский
Процитировано
60
Journal of Ovarian Research, Год журнала: 2024, Номер 17(1)
Опубликована: Май 31, 2024
Abstract In women who are getting older, the quantity and quality of their follicles or oocytes decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, lower oocytes. As more choose to delay childbirth, decline in fertility associated with age has become a significant concern for modern women. The oocyte key indicator aging. Many studies suggest that age-related changes energy metabolism may impact quality. Changes affect adenosine 5'-triphosphate (ATP) production, but how related products proteins influence remains largely unknown. review focuses on aging its potential quality, as well therapeutic strategies partially metabolism. research aims enhance our understanding metabolism, identification biomarkers treatment methods.
Язык: Английский
Процитировано
17
Trends in Food Science & Technology, Год журнала: 2021, Номер 112, С. 201 - 211
Опубликована: Апрель 7, 2021
Язык: Английский
Процитировано
53
GeroScience, Год журнала: 2020, Номер 43(3), С. 1113 - 1121
Опубликована: Сен. 10, 2020
Язык: Английский
Процитировано
52