Biomolecules,
Journal Year:
2020,
Volume and Issue:
10(5), P. 780 - 780
Published: May 18, 2020
The
biguanide
metformin
is
the
first
drug
to
be
tested
as
a
gerotherapeutic
in
clinical
trial
TAME
(Targeting
Aging
with
Metformin).
current
consensus
that
exerts
indirect
pleiotropy
on
core
metabolic
hallmarks
of
aging,
such
insulin/insulin-like
growth
factor
1
and
AMP-activated
protein
kinase/mammalian
Target
Of
Rapamycin
signaling
pathways,
downstream
its
primary
inhibitory
effect
mitochondrial
respiratory
complex
I.
Alternatively,
but
not
mutually
exclusive,
can
exert
regulatory
effects
components
biologic
machinery
aging
itself
chromatin-modifying
enzymes.
An
integrative
metabolo-epigenetic
outlook
supports
new
model
whereby
operates
guardian
cell
identity,
capable
retarding
cellular
by
preventing
loss
information-theoretic
nature
epigenome.
ultimate
anti-aging
mechanism
might
involve
global
preservation
epigenome
architecture,
thereby
ensuring
fate
commitment
phenotypic
outcomes
despite
challenging
noise.
Metformin
therefore
inspire
development
gerotherapeutics
preserving
architecture
for
identity.
Such
should
replicate
ability
halt
erosion
epigenetic
landscape,
mitigate
commitment,
delay
stochastic/environmental
DNA
methylation
drifts,
alleviate
senescence.
Yet,
it
remains
challenge
confirm
if
changes
higher-order
genomic
organizers
connect
capacity
dynamically
regulate
three-dimensional
landscapes
4th
dimension,
time.
Science,
Journal Year:
2022,
Volume and Issue:
378(6618)
Published: Oct. 27, 2022
Spermidine
(SPD)
delays
age-related
pathologies
in
various
organisms.
SPD
supplementation
overcame
the
impaired
immunotherapy
against
tumors
aged
mice
by
increasing
mitochondrial
function
and
activating
CD8+
T
cells.
Treatment
of
naïve
cells
with
acutely
enhanced
fatty
acid
oxidation.
conjugated
to
beads
bound
trifunctional
protein
(MTP).
In
MTP
complex,
synthesized
purified
from
Escherichia
coli,
α
β
subunits
strong
affinity
allosterically
their
enzymatic
activities.
cell-specific
deletion
subunit
abolished
enhancement
programmed
cell
death
1
(PD-1)
blockade
SPD,
indicating
that
is
required
for
SPD-dependent
activation.
Cells,
Journal Year:
2022,
Volume and Issue:
11(4), P. 672 - 672
Published: Feb. 15, 2022
Senescence
is
a
complex
cellular
stress
response
that
abolishes
proliferative
capacity
and
generates
unique
secretory
pattern
implicated
in
organismal
aging
age-related
disease.
How
cell
transitions
to
senescent
state
multifactorial
often
requires
transcriptional
regulation
of
multiple
genes.
Epigenetic
alterations
DNA
chromatin
are
powerful
regulators
genome
architecture
gene
expression,
they
play
crucial
role
mediating
the
induction
maintenance
senescence.
This
review
will
highlight
changes
chromatin,
methylation,
histone
establish
maintain
senescence,
alongside
specific
epigenetic
senescence-associated
phenotype
(SASP).
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: March 14, 2023
Abstract
The
ageing
process
is
a
systemic
decline
from
cellular
dysfunction
to
organ
degeneration,
with
more
predisposition
deteriorated
disorders.
Rejuvenation
refers
giving
aged
cells
or
organisms
youthful
characteristics
through
various
techniques,
such
as
reprogramming
and
epigenetic
regulation.
great
leaps
in
rejuvenation
prove
that
not
one-way
street,
many
rejuvenative
interventions
have
emerged
delay
even
reverse
the
process.
Defining
mechanism
by
which
roadblocks
signaling
inputs
influence
complex
programs
essential
for
understanding
developing
strategies.
Here,
we
discuss
intrinsic
extrinsic
factors
counteract
cell
rejuvenation,
targeted
core
mechanisms
involved
this
Then,
critically
summarize
latest
advances
state-of-art
strategies
of
rejuvenation.
Various
methods
also
provide
insights
treating
specific
ageing-related
diseases,
including
reprogramming,
removal
senescence
(SCs)
suppression
senescence-associated
secretory
phenotype
(SASP),
metabolic
manipulation,
stem
cells-associated
therapy,
dietary
restriction,
immune
heterochronic
transplantation,
etc.
potential
applications
therapy
extend
cancer
treatment.
Finally,
analyze
detail
therapeutic
opportunities
challenges
technology.
Deciphering
will
further
into
anti-ageing
disease
treatment
clinical
settings.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(12), P. 4550 - 4550
Published: Dec. 18, 2021
The
role
of
the
microbiome
in
human
aging
is
important:
directly
impacts
through
gastrointestinal
system.
However,
microbial
impact
on
skin
has
yet
to
be
fully
understood.
For
example,
cellular
senescence
an
intrinsic
process
that
been
recently
associated
with
imbalance.
With
age,
cells
become
senescent
response
stress
wherein
they
undergo
irreversible
growth
arrest
while
maintaining
high
metabolic
activity.
An
accumulation
linked
various
and
chronic
pathologies
due
overexpression
senescence-associated
secretory
phenotype
(SASP)
comprised
proinflammatory
cytokines,
chemokines,
factors,
proteases,
lipids
extracellular
matrix
components.
In
particular,
dermatological
disorders
may
promoted
by
as
a
common
site
accumulation.
gut
microbiota
influences
disruption
gut-skin
axis
secretion
metabolites.
Metabolomics
can
used
identify
quantify
metabolites
involved
senescence.
Moreover,
novel
anti-senescent
therapeutics
are
warranted
given
poor
safety
profiles
current
pharmaceutical
drugs.
Probiotics
prebiotics
effective
alternatives,
considering
relationship
between
healthy
aging.
further
research
composition
under
status
needed
develop
immunomodulatory
therapies.
PROTEOMICS,
Journal Year:
2020,
Volume and Issue:
20(5-6)
Published: Feb. 18, 2020
Abstract
Aging
biology
is
intimately
associated
with
dysregulated
metabolism,
which
one
of
the
hallmarks
aging.
Aging‐related
pathways
such
as
mTOR
and
AMPK,
are
major
targets
anti‐aging
interventions
including
rapamcyin,
metformin,
exercise,
either
directly
regulate
or
intersect
metabolic
pathways.
In
this
review,
numerous
candidate
bio‐markers
aging
that
have
emerged
using
metabolomics
outlined.
Metabolomics
studies
also
reveal
not
all
metabolites
created
equally.
A
set
core
“hub”
emerging
central
mediators
The
hub
reviewed
here
nicotinamide
adenine
dinucleotide,
reduced
dinucleotide
phosphate,
α‐ketoglutarate,
β‐hydroxybutyrate.
These
signaling
epigenetic
roles
along
their
canonical
co‐factors
intermediates
carbon
metabolism.
Together
these
suggest
a
role
TCA
cycle
in
dysregulation
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(10), P. 3420 - 3420
Published: Sept. 28, 2021
The
ketone
bodies,
especially
β-hydroxybutyrate
(β-HB),
derive
from
fatty
acid
oxidation
and
alternatively
serve
as
a
fuel
source
for
peripheral
tissues
including
the
brain,
heart,
skeletal
muscle.
β-HB
is
currently
considered
not
solely
an
energy
substrate
maintaining
metabolic
homeostasis
but
also
acts
signaling
molecule
of
modulating
lipolysis,
oxidative
stress,
neuroprotection.
Besides,
it
serves
epigenetic
regulator
in
terms
histone
methylation,
acetylation,
β-hydroxybutyrylation
to
delay
various
age-related
diseases.
In
addition,
studies
support
endogenous
administration
or
exogenous
supplementation
effective
strategies
induce
state
nutritional
ketosis.
purpose
this
review
article
provide
overview
metabolism
its
relationship
application
Future
are
needed
reveal
whether
has
potential
adjunctive
therapy
aging.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(9), P. 5026 - 5026
Published: May 10, 2021
Consuming
a
balanced,
nutritious
diet
is
important
for
maintaining
health,
especially
as
individuals
age.
Several
studies
suggest
that
consuming
rich
in
antioxidants
and
anti-inflammatory
components
such
those
found
fruits,
nuts,
vegetables,
fish
may
reduce
age-related
cognitive
decline
the
risk
of
developing
various
neurodegenerative
diseases.
Numerous
have
been
published
over
last
decade
focusing
on
nutrition
how
this
impacts
health.
The
main
objective
current
article
to
review
data
linking
role
with
aging
decline.
Specifically,
we
discuss
roles
micronutrients
macronutrients
provide
an
overview
gut
microbiota-gut-brain
axis
impact
brain
function
general
processes
particular
during
aging.
We
propose
dietary
interventions
designed
optimize
levels
macro
maximize
functioning
can
be
therapeutic
value
improving
functioning,
particularly
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 31, 2024
Abstract
In
women
who
are
getting
older,
the
quantity
and
quality
of
their
follicles
or
oocytes
decline.
This
is
characterized
by
decreased
ovarian
reserve
function
(DOR),
fewer
remaining
oocytes,
lower
oocytes.
As
more
choose
to
delay
childbirth,
decline
in
fertility
associated
with
age
has
become
a
significant
concern
for
modern
women.
The
oocyte
key
indicator
aging.
Many
studies
suggest
that
age-related
changes
energy
metabolism
may
impact
quality.
Changes
affect
adenosine
5'-triphosphate
(ATP)
production,
but
how
related
products
proteins
influence
remains
largely
unknown.
review
focuses
on
aging
its
potential
quality,
as
well
therapeutic
strategies
partially
metabolism.
research
aims
enhance
our
understanding
metabolism,
identification
biomarkers
treatment
methods.
