The
skin
serves
as
a
critical
barrier
against
external
pathogens,
and
its
wound
healing
is
complex
biological
process
that
requires
careful
management
to
ensure
optimal
tissue
regeneration.
Hydrogels,
class
of
hydrophilic
polymers,
have
emerged
promising
materials
for
dressings
due
their
biocompatibility,
biodegradability,
ability
create
moist
environment
conducive
cell
proliferation
migration.
In
this
research,
hydrogel
dressing
containing
cefdinir
(Cef)
was
made
from
combination
carboxymethyl
cellulose
(CMC)
gelatin
(Gel)
by
physical
crosslinking
method,
physicochemical,
mechanical,
properties
were
investigated.
Results
show
the
addition
Cef
does
not
cause
significant
change
in
morphology
or
tensile
strength
dressing.
swelling
degradation
rate
slightly
increased
presence
Cef.
enhanced
antibacterial
effects
up
2.5-fold
P.
aeruginosa
(35
mm),
S.
aureus
(36
pyogenes
mm).
results
cytotoxicity
test
showed
absence
both
drug-containing
drug-free
dressings,
well
survival
over
75%
cells
after
48
h.
accelerates
formation
epidermis
layer
production
fibroblast
cells,
result,
process.
percentage
on
ninth
day
treatment
an
untreated
30%,
while
40%
with
without
medicine
60%
medicine,
fifteenth
treatment,
treated
had
more
than
85%
healing.
As
it
possible
use
CMC/Gel
polymeric
healing,
according
desired
physicochemical
biocompatibility.
The
care
and
rehabilitation
of
acute
chronic
wounds
have
a
significant
social
economic
impact
on
patients
global
health.
This
burden
is
primarily
due
to
the
adverse
effects
infections,
prolonged
recovery,
associated
treatment
costs.
Chronic
can
be
treated
with
variety
approaches,
which
include
surgery,
negative
pressure
wound
therapy,
dressings,
hyperbaric
oxygen
therapy.
However,
each
these
strategies
has
an
array
limitations.
existing
dry
dressings
lack
functionality
in
promoting
healing
exacerbating
pain
by
adhering
wound.
Hydrogels,
are
commonly
polymer-based
swell
water,
been
proposed
as
potential
remedies
their
ability
provide
moist
environment
that
facilitates
healing.
Their
unique
composition
enables
them
absorb
exudates,
exhibit
shape
adaptability,
modified
incorporate
active
compounds
such
growth
factors
antibacterial
compounds.
review
provides
updated
discussion
leading
natural
synthetic
hydrogels
utilized
healing,
details
latest
advancements
hydrogel
technology,
explores
alternate
approaches
this
field.
Search
engines
Scopus,
PubMed,
Science
Direct,
Web
were
advances
applications
over
last
fifteen
years.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Апрель 27, 2024
Abstract
An
asymmetrical
wound
dressing
functions
akin
to
human
skin
by
serving
as
a
protective
barrier
between
and
its
immediate
environment.
However,
significant
challenges
persist
concerning
the
robust
adhesion
properties
of
hydrogels,
particularly
when
applied
in
emergency
hemostasis
healing
contexts.
Herein,
study
has
successfully
synthesized
hydrogel
patches
with
Janus
asymmetric‐adhesion,
denoted
HGO‐C,
exclusively
comprised
natural
polymers.
This
achievement
is
realized
through
assembly
adhesive
(HGO)
non‐adhesive
(CGC),
thereby
amalgamating
their
distinct
functionalities.
The
component
served
physical
shield
safeguarding
against
contamination,
while
hydrogel,
contacted
surface,
firmly
adhered
it,
swiftly
arresting
bleeding
facilitating
healing.
Cytocompatibility
tests,
hemolysis
antibacterial
assays,
coagulation
assays
demonstrated
excellent
biocompatibility,
antibacterial,
hemostatic
HGO‐C.
Finally,
vivo
experiments,
including
liver
hemorrhage
assay
assay,
unequivocally
showed
rapid
enhanced
capabilities
Consequently,
these
distinctive
patches,
derived
from
polymers
characterized
asymmetric
properties,
may
have
great
potential
for
real‐life
usage
clinical
patients.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 2660 - 2676
Опубликована: Май 9, 2024
Wound
healing,
particularly
for
chronic
wounds,
presents
a
considerable
difficulty
due
to
differences
in
biochemical
and
cellular
processes
that
occur
different
types
of
wounds.
Recent
technological
breakthroughs
have
notably
advanced
the
understanding
diagnostic
therapeutic
approaches
wound
healing.
The
evolution
care
has
seen
transition
from
traditional
textile
dressings
variety
alternatives,
including
self-healing
hydrogels,
hydrofibers,
foams,
hydrocolloids,
environment
responsive
dressings,
growth
factor-based
therapy,
bioengineered
skin
substitutes,
stem
cell
gene
therapy.
Technological
advancements,
such
as
3D
printing
electronic
(e-skin)
contribute
customization
Despite
these
effectively
managing
wounds
remains
challenging.
This
necessitates
development
treatments
consider
performance,
risk–benefit
balance,
cost-effectiveness.
review
discusses
innovative
strategies
healing
Incorporating
biomarkers
into
coupled
with
corresponding
biosensors
drug
delivery
formulations,
enables
theranostic
approach
treatment
Furthermore,
integrating
power
sources
user
interfaces
like
near-field
communication,
radio
frequency
identification,
Bluetooth
enhances
real-time
monitoring
on-demand
delivery.
It
also
provides
thorough
evaluation
advantages,
patient
compliance,
costs,
durability
emphasizing
smart
formulations
their
preparation
methods.
Materials Today Bio,
Год журнала:
2024,
Номер
25, С. 100960 - 100960
Опубликована: Янв. 26, 2024
Chronic
inflammation
can
delay
wound
healing,
eventually
leading
to
tissue
necrosis
and
even
cancer.
Developing
real-time
intelligent
monitoring
treatment
achieve
effective
management
is
important
promote
healing.
In
this
study,
a
smart
multifunctional
hydrogel
(Hydrogel@Au
NCs&DG)
was
proposed
monitor
treat
the
inflammation.
It
prepared
by
mixing
3-carboxy-phenylboronic
acid
modified
chitosan
(CS-cPBA),
β-glycerophosphate
(β-GP),
albumin-protected
gold
nanoclusters
(BSA-Au
NCs),
dipotassium
glycyrrhizinate
(DG)
about
10
s.
hydrogel,
CS-cPBA
β-GP
are
crosslinked
together
boric
ester
bond
hydrogen
form
main
network,
endowing
with
self-healing
injectable
properties
adapt
irregular
wounds.
Importantly,
as-prepared
good
biocompatibility
excellent
adhesion
property
could
directly
determine
H2O2
microenvironment
visible
fluorescence
change
of
BSA-Au
NCs
then
guide
frequency
dressing
eliminate
The
results
demonstrated
that
be
expected
serve
as
an
inflammation-infected
Gels,
Год журнала:
2025,
Номер
11(3), С. 174 - 174
Опубликована: Фев. 27, 2025
In
this
study,
a
hydrogel
material
based
on
porcine
gelatin
and
sodium
alginate
was
synthesized
for
use
as
dressing
chronic
wound
treatment.
The
hydrogels
were
covalently
cross-linked
using
polyethylene
glycol
diglycidyl
ether
(PEGDE
500),
the
interaction
between
components
confirmed
via
FTIR.
properties
of
resulting
examined,
including
gel-fraction
volume,
swelling
degree
in
different
media,
mechanical
properties,
pore
size,
cytotoxicity,
ability
to
absorb
release
analgesics
(lidocaine,
novocaine,
diclofenac).
hydrogel’s
resistance
enzymatic
action
by
protease
enhanced
both
through
chemical
cross-linking
physical
interactions
alginate.
absorption
capacity
hydrogels,
reaching
90
g
per
dm2
dressing,
indicates
their
potential
absorbing
exudates.
It
demonstrated
that
antiseptic
(chlorhexidine)
contained
structured
gelatin–alginate
can
be
released
into
an
infected
substrate,
significant
inhibition
pathogenic
microorganisms
(Escherichia
coli,
Staphylococcus
aureus,
Pseudomonas
aeruginosa,
Aspergillus
niger).
These
results
clearly
demonstrate
obtained
materials
serve
non-traumatic
dressings
treatment
and/or
wounds.
