International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135052 - 135052
Published: Aug. 24, 2024
Language: Английский
Gels, Journal Year: 2024, Volume and Issue: 10(1), P. 43 - 43
Published: Jan. 5, 2024
The care and rehabilitation of acute chronic wounds have a significant social economic impact on patients global health. This burden is primarily due to the adverse effects infections, prolonged recovery, associated treatment costs. Chronic can be treated with variety approaches, which include surgery, negative pressure wound therapy, dressings, hyperbaric oxygen therapy. However, each these strategies has an array limitations. existing dry dressings lack functionality in promoting healing exacerbating pain by adhering wound. Hydrogels, are commonly polymer-based swell water, been proposed as potential remedies their ability provide moist environment that facilitates healing. Their unique composition enables them absorb exudates, exhibit shape adaptability, modified incorporate active compounds such growth factors antibacterial compounds. review provides updated discussion leading natural synthetic hydrogels utilized healing, details latest advancements hydrogel technology, explores alternate approaches this field. Search engines Scopus, PubMed, Science Direct, Web were advances applications over last fifteen years.
Language: Английский
Citations
71
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)
Published: April 27, 2024
Abstract An asymmetrical wound dressing functions akin to human skin by serving as a protective barrier between and its immediate environment. However, significant challenges persist concerning the robust adhesion properties of hydrogels, particularly when applied in emergency hemostasis healing contexts. Herein, study has successfully synthesized hydrogel patches with Janus asymmetric‐adhesion, denoted HGO‐C, exclusively comprised natural polymers. This achievement is realized through assembly adhesive (HGO) non‐adhesive (CGC), thereby amalgamating their distinct functionalities. The component served physical shield safeguarding against contamination, while hydrogel, contacted surface, firmly adhered it, swiftly arresting bleeding facilitating healing. Cytocompatibility tests, hemolysis antibacterial assays, coagulation assays demonstrated excellent biocompatibility, antibacterial, hemostatic HGO‐C. Finally, vivo experiments, including liver hemorrhage assay assay, unequivocally showed rapid enhanced capabilities Consequently, these distinctive patches, derived from polymers characterized asymmetric properties, may have great potential for real‐life usage clinical patients.
Language: Английский
Citations
38
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 2660 - 2676
Published: May 9, 2024
Wound healing, particularly for chronic wounds, presents a considerable difficulty due to differences in biochemical and cellular processes that occur different types of wounds. Recent technological breakthroughs have notably advanced the understanding diagnostic therapeutic approaches wound healing. The evolution care has seen transition from traditional textile dressings variety alternatives, including self-healing hydrogels, hydrofibers, foams, hydrocolloids, environment responsive dressings, growth factor-based therapy, bioengineered skin substitutes, stem cell gene therapy. Technological advancements, such as 3D printing electronic (e-skin) contribute customization Despite these effectively managing wounds remains challenging. This necessitates development treatments consider performance, risk–benefit balance, cost-effectiveness. review discusses innovative strategies healing Incorporating biomarkers into coupled with corresponding biosensors drug delivery formulations, enables theranostic approach treatment Furthermore, integrating power sources user interfaces like near-field communication, radio frequency identification, Bluetooth enhances real-time monitoring on-demand delivery. It also provides thorough evaluation advantages, patient compliance, costs, durability emphasizing smart formulations their preparation methods.
Language: Английский
Citations
19
AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 8, 2025
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134990 - 134990
Published: Aug. 23, 2024
Language: Английский
Citations
13
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093
Published: July 25, 2024
Language: Английский
Citations
12
Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100960 - 100960
Published: Jan. 26, 2024
Chronic inflammation can delay wound healing, eventually leading to tissue necrosis and even cancer. Developing real-time intelligent monitoring treatment achieve effective management is important promote healing. In this study, a smart multifunctional hydrogel (Hydrogel@Au NCs&DG) was proposed monitor treat the inflammation. It prepared by mixing 3-carboxy-phenylboronic acid modified chitosan (CS-cPBA), β-glycerophosphate (β-GP), albumin-protected gold nanoclusters (BSA-Au NCs), dipotassium glycyrrhizinate (DG) about 10 s. hydrogel, CS-cPBA β-GP are crosslinked together boric ester bond hydrogen form main network, endowing with self-healing injectable properties adapt irregular wounds. Importantly, as-prepared good biocompatibility excellent adhesion property could directly determine H2O2 microenvironment visible fluorescence change of BSA-Au NCs then guide frequency dressing eliminate The results demonstrated that be expected serve as an inflammation-infected
Language: Английский
Citations
11
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 174 - 174
Published: Feb. 27, 2025
In this study, a hydrogel material based on porcine gelatin and sodium alginate was synthesized for use as dressing chronic wound treatment. The hydrogels were covalently cross-linked using polyethylene glycol diglycidyl ether (PEGDE 500), the interaction between components confirmed via FTIR. properties of resulting examined, including gel-fraction volume, swelling degree in different media, mechanical properties, pore size, cytotoxicity, ability to absorb release analgesics (lidocaine, novocaine, diclofenac). hydrogel’s resistance enzymatic action by protease enhanced both through chemical cross-linking physical interactions alginate. absorption capacity hydrogels, reaching 90 g per dm2 dressing, indicates their potential absorbing exudates. It demonstrated that antiseptic (chlorhexidine) contained structured gelatin–alginate can be released into an infected substrate, significant inhibition pathogenic microorganisms (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Aspergillus niger). These results clearly demonstrate obtained materials serve non-traumatic dressings treatment and/or wounds.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142134 - 142134
Published: March 1, 2025
Language: Английский
Citations
1
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 345, P. 122585 - 122585
Published: Aug. 8, 2024
Language: Английский
Citations
8