Journal of Biochemical and Molecular Toxicology,
Год журнала:
2023,
Номер
38(1)
Опубликована: Дек. 9, 2023
COVID-19
is
caused
by
a
novel
SARS-CoV-2
leading
to
pulmonary
and
extra-pulmonary
manifestations
due
oxidative
stress
(OS)
development
hyperinflammation.
primarily
asymptomatic
though
it
may
cause
acute
lung
injury
(ALI),
respiratory
distress
syndrome
(ARDS),
systemic
inflammation,
thrombotic
events
in
severe
cases.
SARS-CoV-2-induced
OS
triggers
the
activation
of
different
signaling
pathways,
which
counterbalances
this
complication.
One
these
pathways
nuclear
factor
erythroid
2-related
2
(Nrf2),
induces
series
cellular
interactions
mitigate
SARS-CoV-2-mediated
viral
toxicity
OS-induced
injury.
Nrf2
pathway
inhibits
expression
pro-inflammatory
cytokines
cytokine
storm
COVID-19.
Therefore,
activators
play
an
essential
role
reducing
infection-induced
inflammation
suppressing
NLRP3
inflammasome
Furthermore,
can
attenuate
endothelial
dysfunction
(ED),
renin-angiotensin
system
(RAS)
dysregulation,
immune
thrombosis,
coagulopathy.
Thus
mini-review
tries
clarify
possible
management
could
be
effective
therapeutic
strategy
Covid-19.
Preclinical
clinical
studies
are
recommended
regard.
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(10)
Опубликована: Май 1, 2024
Parkinson's
disease
(PD)
is
a
neurodegenerative
disorder
of
the
brain
and
manifested
by
motor
non-motor
symptoms
because
degenerative
changes
in
dopaminergic
neurons
substantia
nigra.
PD
neuropathology
associated
with
mitochondrial
dysfunction,
oxidative
damage
apoptosis.
Thus,
modulation
apoptosis
growth
factors
could
be
novel
boulevard
management
PD.
Brain-derived
neurotrophic
factor
(BDNF)
its
receptor
tropomyosin
kinase
type
B
(TrkB)
are
chiefly
involved
neuropathology.
BDNF
promotes
survival
nigra
enhances
functional
activity
striatal
neurons.
Deficiency
TrkB
triggers
degeneration
accumulation
α-Syn
As
well,
BDNF/TrkB
signalling
reduced
early
phase
Targeting
specific
activators
may
attenuate
this
review
aimed
to
discuss
potential
role
against
In
conclusion,
decreased
linked
severity
long-term
complications.
Activation
Autophagy,
Год журнала:
2023,
Номер
20(2), С. 259 - 274
Опубликована: Сен. 15, 2023
Multiple
sclerosis
(MS)
is
a
chronic
progressive
demyelinating
disease
of
the
central
nervous
system
(CNS)
due
to
an
increase
abnormal
peripherally
auto-reactive
T
lymphocytes
which
elicit
autoimmunity.
The
main
pathophysiology
MS
myelin
sheath
damage
by
immune
cells
and
defect
in
generation
oligodendrocytes.
Macroautophagy/autophagy
critical
degradation
process
that
eliminates
dysfunctional
or
superfluous
cellular
components.
Autophagy
has
property
double-edged
sword
it
may
have
both
beneficial
detrimental
effects
on
neuropathology.
Therefore,
this
review
illustrates
protective
harmful
autophagy
with
regard
disease.
prevents
progression
reducing
oxidative
stress
inflammatory
disorders.
In
contrast,
over-activated
associated
neuropathology
case
use
inhibitors
alleviate
pathogenesis
MS.
Furthermore,
provokes
activation
different
supporting
play
intricate
role
functions
modulation
regulating
cell
proliferation
related
demyelination
remyelination.
enhances
remyelination
increasing
activity
oligodendrocytes,
astrocytes.
However,
induces
activating
microglia
cells.
conclusion,
specific
autophagic
activators
astrocytes,
dendritic
(DCs),
induce
against
Pharmacology Research & Perspectives,
Год журнала:
2023,
Номер
11(2)
Опубликована: Фев. 22, 2023
Parkinson's
disease
(PD)
is
the
second
most
frequent
neurodegenerative
brain
(NBD)
after
Alzheimer's
(AD).
Statins
are
common
lipid-lowering
agents
used
in
management
of
dyslipidemia
and
prevention
primary
secondary
cardiovascular
diseases
(CVD)
events.
In
addition,
there
a
controversial
point
regarding
role
serum
lipids
pathogenesis
PD.
this
bargain,
as
statins
reduce
cholesterol
so
they
affect
PD
neuropathology
bidirectional
ways
either
protective
or
harmful.
not
PD,
but
frequently
disorders
commonly
associated
with
elderly
population.
Therefore,
use
that
population
may
outcomes.
Concerning
potential
on
neuropathology,
conflicts
controversies
against
development
harmful
by
increasing
risk
for
review
aimed
to
clarify
precise
pros
cons
from
published
studies.
Many
studies
suggest
through
modulation
inflammatory
lysosomal
signaling
pathways.
Nevertheless,
other
observations
statin
therapy
increase
diverse
mechanisms
including
reduction
CoQ10.
conclusion,
strong
neuropathology.
retrospective
prospective
necessary
regard.
Autophagy,
Год журнала:
2024,
Номер
20(7), С. 1473 - 1482
Опубликована: Фев. 12, 2024
Myasthenia
gravis
(MG)
is
an
autoimmune
disease
of
the
neuromuscular
junction
(NMJ)
that
results
from
autoantibodies
against
nicotinic
acetylcholine
receptors
(nAchRs)
at
NMJs.
These
are
mainly
originated
autoreactive
B
cells
bind
and
destroy
nAchRs
NMJs
preventing
nerve
impulses
activating
end-plates
skeletal
muscle.
Indeed,
immune
dysregulation
plays
a
crucial
role
in
pathogenesis
MG.
Autoreactive
increased
MG
due
to
defect
central
peripheral
tolerance
mechanisms.
As
well,
T
augmented
diversion
regulatory
(T
