Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102233 - 102233

Published: Feb. 14, 2024

Language: Английский

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New insight on the possible role of statins in Vascular Parkinsonism: A need for presumptive therapy

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102209 - 102209

Published: Jan. 28, 2024

Language: Английский

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BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(10)

Published: May 1, 2024

Parkinson's disease (PD) is a neurodegenerative disorder of the brain and manifested by motor non-motor symptoms because degenerative changes in dopaminergic neurons substantia nigra. PD neuropathology associated with mitochondrial dysfunction, oxidative damage apoptosis. Thus, modulation apoptosis growth factors could be novel boulevard management PD. Brain-derived neurotrophic factor (BDNF) its receptor tropomyosin kinase type B (TrkB) are chiefly involved neuropathology. BDNF promotes survival nigra enhances functional activity striatal neurons. Deficiency TrkB triggers degeneration accumulation α-Syn As well, BDNF/TrkB signalling reduced early phase Targeting specific activators may attenuate this review aimed to discuss potential role against In conclusion, decreased linked severity long-term complications. Activation

Language: Английский

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Metformin role in Parkinson’s disease: a double-sword effect

Molecular and Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 479(4), P. 975 - 991

Published: June 2, 2023

Language: Английский

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Pros and cons for statins use and risk of Parkinson's disease: An updated perspective

Pharmacology Research & Perspectives, Journal Year: 2023, Volume and Issue: 11(2)

Published: Feb. 22, 2023

Parkinson's disease (PD) is the second most frequent neurodegenerative brain (NBD) after Alzheimer's (AD). Statins are common lipid-lowering agents used in management of dyslipidemia and prevention primary secondary cardiovascular diseases (CVD) events. In addition, there a controversial point regarding role serum lipids pathogenesis PD. this bargain, as statins reduce cholesterol so they affect PD neuropathology bidirectional ways either protective or harmful. not PD, but frequently disorders commonly associated with elderly population. Therefore, use that population may outcomes. Concerning potential on neuropathology, conflicts controversies against development harmful by increasing risk for review aimed to clarify precise pros cons from published studies. Many studies suggest through modulation inflammatory lysosomal signaling pathways. Nevertheless, other observations statin therapy increase diverse mechanisms including reduction CoQ10. conclusion, strong neuropathology. retrospective prospective necessary regard.

Language: Английский

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The beneficial role of autophagy in multiple sclerosis: Yes or No?

Autophagy, Journal Year: 2023, Volume and Issue: 20(2), P. 259 - 274

Published: Sept. 15, 2023

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system (CNS) due to an increase abnormal peripherally auto-reactive T lymphocytes which elicit autoimmunity. The main pathophysiology MS myelin sheath damage by immune cells and defect in generation oligodendrocytes. Macroautophagy/autophagy critical degradation process that eliminates dysfunctional or superfluous cellular components. Autophagy has property double-edged sword it may have both beneficial detrimental effects on neuropathology. Therefore, this review illustrates protective harmful autophagy with regard disease. prevents progression reducing oxidative stress inflammatory disorders. In contrast, over-activated associated neuropathology case use inhibitors alleviate pathogenesis MS. Furthermore, provokes activation different supporting play intricate role functions modulation regulating cell proliferation related demyelination remyelination. enhances remyelination increasing activity oligodendrocytes, astrocytes. However, induces activating microglia cells. conclusion, specific autophagic activators astrocytes, dendritic (DCs), induce against

Language: Английский

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The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102084 - 102084

Published: Oct. 5, 2023

Language: Английский

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The potential therapeutic effect of statins in multiple sclerosis: beneficial or detrimental effects

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(4), P. 1671 - 1682

Published: May 9, 2023

Language: Английский

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Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102119 - 102119

Published: Nov. 4, 2023

Language: Английский

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The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102075 - 102075

Published: Sept. 14, 2023

Language: Английский

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