Green Fabrication of CdS Quantum Dots Using Household Indian Spices for Its Potential Anticancer Activity Against Human Breast Cancer Cells (MCF-7) and Other Biological Applications

Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Язык: Английский

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SWCNTs functionalized with gold nanoradiosensitizers as radiosensitizers for enhanced radiotherapy in breast cancer

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102113 - 102113

Опубликована: Фев. 1, 2025

Язык: Английский

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Synthesis, characterization, biological activity, DFT, molecular docking and ADME studies of metal (II) complexes of a bidentate Schiff’s base (E)-4-chloro-2-((2-hydroxy-3-methoxybenzylidene)amino)benzoic acid

Journal of Dispersion Science and Technology, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Фев. 11, 2025

Язык: Английский

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RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 259, С. 129157 - 129157

Опубликована: Янв. 8, 2024

Oral cancer incidence and mortality are increasing over time. The most common therapies for oral cancers surgery radiotherapy, either used alone or combined, immunotherapy can be also an option. Although there several therapeutic options, none of them completely effective, in addition, numerous associated side effects. To overcome these limitations, researchers have been trying to reduce drawbacks by using drug delivery systems that carry drugs specific cells. For purpose, RNA-coated liposomes selectively deliver the ligands C8 (acridine orange derivative) dexamethasone cells were produced, characterized, biologically evaluated. Firstly, RNA structure binding interaction with (C8 dexamethasone) evaluated circular dichroism (CD), thermal difference spectroscopy (TDS), nuclear magnetic resonance (NMR) fluorescence titrations. biophysical assays evidenced formation hairpin duplex structure. Moreover, steady-state time-resolved intensity anisotropy experiments show forms a complex adopts open conformation upon binding. Then, characterized dynamic light scattering, diameters near 160 nm observed. Time-resolved measurements loaded RNA-functionalized indicate co-existence free solution (inside liposome) bound at external liposome surface. mediated significant reduction cell viability malignant UPCI-SCC-154 while maintaining viable non-malignant NHDF Additionally, able internalize cells, higher uptake line. Overall, results obtained this work contribute development new based on liposomes.

Язык: Английский

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Synthesis of curcumin loaded single walled carbon nanotubes: Characterization and anticancer effects in vitro

Results in Chemistry, Год журнала: 2024, Номер 7, С. 101370 - 101370

Опубликована: Янв. 1, 2024

Curcumin, derived from Curcuma longa, is a widely used natural compound in anticancer treatments. Single-walled carbon nanotubes (SWCNTs), significant class of nanomaterials known for their unique physicochemical properties, serve as effective carriers curcumin. This allows the utilization curcumin's antitumor capabilities while overcoming its conventional drawbacks low aqueous solubility and instability under physiological conditions. In current study, SWCNTs were cultivated without hydrogen gas, utilizing Fe-Mo/Al2O3 catalyst. Once prepared by Chemical Vapor Deposition (CVD) method ideal conditions, they combined with Various techniques, including Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS), UV–Vis, Fourier Transform Infrared (FTIR), Raman, X-Ray Diffraction (XRD), employed to characterize system. The quality SWCNT was determined ID/IG ratio Raman spectroscopy. DLS technique revealed that ζ-potential SWCNT-Cur approximately −13.9 −25.5 mV, respectively. Nano-formulation had loading capacity 14/87 %. rate hemolysis caused less than 10 %, high cell viability observed HFF-2 cells following MTT test indicates safety Nano-formulation. To validate therapeutic effects on 4T1 line, both presence absence X-ray radiation, assay vitro. results showed increase toxicity breast cancer increasing concentration.

Язык: Английский

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Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(21), С. 11669 - 11669

Опубликована: Окт. 28, 2021

As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well metastasis, these can also mediate resistance to therapy. Furthermore, the presence CSCs leads recurrence therefore their complete eradication have immense therapeutic benefits. present review focuses targeting natural products growth formation capacities been reported be attenuated dietary agents. These compounds induce apoptosis reduce migration invasion via EMT inhibition. A variety molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 NF-κB undergo down-regulation agents suppressing CSC features. Upon exposure agents, significant decrease occurs levels markers CD44, CD133, ALDH1, Oct4 Nanog impair stemness. suppression enhance sensitivity tumors chemotherapy radiotherapy. In addition vitro studies, experiments different preclinical models shown capacity use nanostructures improving impact is recommended rapidly translate findings clinical use.

Язык: Английский

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Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(18), С. 10330 - 10330

Опубликована: Сен. 7, 2022

Gastric cancer (GC) has high incidence rates and constitutes a common cause of mortality. Despite advances in treatment, GC remains challenge therapy which is why novel treatment strategies are needed. The interest natural compounds increased significantly recent years because their numerous biological activities, including anti-cancer action. isolation the bioactive from Coptis chinensis Franch was carried out with Centrifugal Partition Chromatography (CPC) technique, using biphasic solvent system composed chloroform (CHCl3)—methanol (MeOH)—water (H2O) (4:3:3, v/v) an addition hydrochloric acid trietylamine. identity isolated alkaloids confirmed resolution HPLC-MS chromatograph. phytochemical constituents such as berberine, jatrorrhizine, palmatine coptisine inhibited viability growth gastric cell lines ACC-201 NCI-N87 dose-dependent manner, showing highest efficacy revealed MTT BrdU assays, respectively. Flow cytometry analysis coptisine-induced population cells sub-G1 phase apoptosis. combination cisplatin at fixed-ratio 1:1 exerted synergistic additive interactions NCI-N87, respectively, determined by means isobolographic analysis. In vivo assay, safe for developing zebrafish dose equivalent to active vitro, but higher doses (greater than 10 times) caused morphological abnormalities larvae. Our findings provide theoretical foundation further studies on more detailed mechanisms action that inhibit survival vitro settings.

Язык: Английский

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Cisplatin-loaded nanoformulations for cancer therapy: A comprehensive review

Journal of Drug Delivery Science and Technology, Год журнала: 2022, Номер 77, С. 103928 - 103928

Опубликована: Окт. 31, 2022

Язык: Английский

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Synthesis and characterization of biological macromolecules double emulsion based on carboxymethylcellulose/gelatin hydrogel incorporated with ZIF-8 as metal organic frameworks for sustained anti-cancer drug release

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 243, С. 125168 - 125168

Опубликована: Июнь 1, 2023

Язык: Английский

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A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 166, С. 115337 - 115337

Опубликована: Сен. 4, 2023

The fourth common reason of death among patients is gastric cancer (GC) and it a dominant tumor type in Ease Asia. One the problems GC therapy chemoresistance. Cisplatin (CP) platinum compound that causes DNA damage reducing progression viability cells. However, due to hyperactivation drug efflux pumps, dysregulation genes interactions microenvironment, cells can develop resistance CP chemotherapy. current review focuses on emergence with emphasizing molecular pathways, pharmacological compounds for reversing chemoresistance role nanostructures. Changes cell mechanisms such as upregulation pro-survival autophagy prevent CP-mediated apoptosis results resistance. Moreover, increase metastasis via EMT induction induces Dysregulation pathways PTEN, PI3K/Akt, Nrf2 others result changes response Non-coding RNAs determine application activity distinct sensitivity Due efficacy exosomes transferring bioactive molecules RNA cells, also newest progresses overcoming nanoplatforms delivery they accumulation at site by suppressing carcinogenic factors biological barriers, toxicity

Язык: Английский

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