Biomedical application of metal-organic frameworks (MOFs) in cancer therapy: Stimuli-responsive and biomimetic nanocomposites in targeted delivery, phototherapy and diagnosis

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129391 - 129391

Опубликована: Янв. 20, 2024

Язык: Английский

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Modulating macrophage phenotype for accelerated wound healing with chlorogenic acid-loaded nanocomposite hydrogel

Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 420 - 443

Опубликована: Апрель 5, 2024

Язык: Английский

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Novel targeted delivery of quercetin for human hepatocellular carcinoma using starch/polyvinyl alcohol nanocarriers based hydrogel containing Fe2O3 nanoparticles

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 257, С. 128626 - 128626

Опубликована: Дек. 5, 2023

Язык: Английский

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Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 27, 2024

Abstract Regenerative biomedicine has emerged as a forefront area in medical research, heralding new era of therapeutic strategies. This review delineates the integration 2D materials (2DMs) within biomedical engineering, leveraging their superior physicochemical attributes for enhance outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating potential to mitigate limitations inherent each while simultaneously augmenting beneficial properties. In particular, incorporating into hydrogels highlights capability mechanical strength hydrogels, providing biomimetic scaffold tissue engineering regeneration cancer diagnosis therapy. An overview synthetic methodologies are provided 2DMs, elucidating dynamics with biomacromolecules. primarily concentrates on applications biomacromolecule‐reinforced 2DM across various fields, including bone wound healing, neural cardiac well delivery drugs genes, therapy, biosensing technologies. Finally, discusses existing challenges future outlook developing using underlining transformative regenerative medicine.

Язык: Английский

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ZIF-8-enhanced multifunctional, high-performance nanocomposite hydrogel–based wearable strain sensor for healthcare applications

Advanced Composites and Hybrid Materials, Год журнала: 2024, Номер 7(5)

Опубликована: Окт. 1, 2024

Язык: Английский

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Facile fabrication of a thermal/pH responsive IPN hydrogel drug carrier based on cellulose and chitosan through simultaneous dual-click strategy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 827 - 841

Опубликована: Авг. 28, 2024

Язык: Английский

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Recent Advances in Metal–Organic Framework-Based Anticancer Hydrogels

Gels, Год журнала: 2025, Номер 11(1), С. 76 - 76

Опубликована: Янв. 18, 2025

Cancer is the second leading cause of death globally and estimated number new cancer cases deaths will be ∼30.2 million 16.3 million, respectively, by 2040. These numbers massive, physical, emotional, financial burdens to society healthcare system that lead further research for a better more effective therapeutic strategy manage cancer. Metal–organic frameworks (MOFs) are promising alternative approaches efficient drug delivery theranostics owing their unique properties direct transportation drugs into cells followed controlled release, but they suffer from certain limitations like rigidity, poor dispersibility, fragility, aggregation probability, limited surface accessibility. Therefore, MOFs were conjugated with polymeric hydrogels, formation MOF-based hydrogels abundant absorption sites, flexibility, excellent mechanical properties. This review briefly describes different strategies used synthesis characterization hydrogels. Further, we place special emphasis on recent advances in cancers. Finally, conclude challenges future perspectives We believe this help researchers develop augmented anticancer effects, enabling management even without adverse effects.

Язык: Английский

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Enhancing anti-angiogenic immunotherapy for melanoma through injectable metal–organic framework hydrogel co-delivery of combretastatin A4 and poly(I:C)

Nanoscale Advances, Год журнала: 2024, Номер 6(12), С. 3135 - 3145

Опубликована: Янв. 1, 2024

The interplay between vascularization and macrophage-induced immune suppression plays a crucial role in melanoma treatment. In this study, we propose novel combination approach to combat by simultaneously inhibiting tumor enhancing macrophage-mediated anti-tumor responses. We investigate the potential of combining combretastatin A4 (CA4), vascular-disrupting agent, with poly(I:C) (PIC), an immunostimulatory adjuvant. This effectively suppresses cell proliferation, disrupts vascularization, promotes macrophage polarization towards M1 phenotype for suppression. To facilitate efficient co-delivery CA4 PIC enhanced anti-angiogenic immunotherapy, develop injectable metal-organic framework hydrogel using Zeolitic Imidazolate Framework-8 (ZIF-8) hyaluronic acid (HA) (ZIF-8/HA). Our findings demonstrate that ZIF-8 enables loading enhances stability against RNAase degradation

Язык: Английский

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A development of a gelatin and sodium carboxymethyl cellulose hydrogel system for dual-release transdermal delivery of lidocaine hydrochloride

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138034 - 138034

Опубликована: Ноя. 1, 2024

Язык: Английский

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5-Fluorouracil and Anti-EGFR antibody scaffold chitosan-stabilized Pickering emulsion: Formulations, physical characterization, in-vitro studies in NCL-H226 cells, and in-vivo investigations in Wistar rats for the augmented therapeutic effects against squamous cell carcinoma

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126716 - 126716

Опубликована: Сен. 4, 2023

Язык: Английский

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