Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery

Biomaterials Science, Год журнала: 2019, Номер 8(2), С. 552 - 568

Опубликована: Ноя. 11, 2019

Cell membrane coated nanoparticles have been designed for inflammation and cancer therapy. An array of cell membranes from library were extracted leveraged to coat a variety different diseases.

Язык: Английский

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Recent Advances in Glucose‐Oxidase‐Based Nanocomposites for Tumor Therapy

Small, Год журнала: 2019, Номер 15(51)

Опубликована: Ноя. 20, 2019

Abstract Glucose oxidase (GOx) can react with intracellular glucose and oxygen (O 2 ) to produce hydrogen peroxide (H O gluconic acid, which cut off the nutrition source of cancer cells consequently inhibit their proliferation. Therefore, GOx is recognised as an ideal endogenous oxido‐reductase for starvation therapy. This process further regulate tumor microenvironment by increasing hypoxia acidity. Thus, offers new possibilities elaborate design multifunctional nanocomposites However, natural expensive prepare purify exhibits immunogenicity, short in vivo half‐life, systemic toxicity. Furthermore, highly prone degrade after exposure biological conditions. These intrinsic shortcomings will undoubtedly limit its biomedical applications. Accordingly, some nanocarriers be used protect from surrounding environment, thus controlling or preserving activity. A variety including hollow mesoporous silica nanoparticles, metal–organic frameworks, organic polymers, magnetic nanoparticles are summarized construction GOx‐based multimodal synergistic In addition, current challenges promising developments this area highlighted.

Язык: Английский

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Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(17), С. 19543 - 19571

Опубликована: Апрель 26, 2021

Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction even death. Therefore, realizing precise organelle targeting photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for construction next generation may implementable strategies future precision medicine. In this Review, recent different corresponding design principles molecular nanostructured summarized discussed. The current challenges opportunities organelle-targeted PDT also presented.

Язык: Английский

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Cancer Cell Membrane-Coated Nanoparticles for Cancer Management

Cancers, Год журнала: 2019, Номер 11(12), С. 1836 - 1836

Опубликована: Ноя. 21, 2019

Cancer is a global health problem in need of transformative treatment solutions for improved patient outcomes. Many conventional treatments prove ineffective and produce undesirable side effects because they are incapable targeting only cancer cells within tumors metastases post administration. There desperate targeted therapies that can maximize success minimize toxicity. Nanoparticles (NPs) with tunable physicochemical properties have potential to meet the high precision therapies. At forefront nanomedicine biomimetic nanotechnology, which hides NPs from immune system provides superior capabilities by cloaking cell-derived membranes. cell membranes expressing “markers self” “self-recognition molecules” be removed wrapped around variety NPs, providing homotypic circumventing challenge synthetically replicating natural surfaces. Compared unwrapped membrane-wrapped (CCNPs) provide reduced accumulation healthy tissues higher metastases. The unique biointerfacing CCNPs enable their use as nanovehicles enhanced drug delivery, localized phototherapy, intensified imaging, or more potent immunotherapy. This review summarizes state-of-the-art CCNP technology insight path forward clinical implementation.

Язык: Английский

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Physical Properties of Nanoparticles That Result in Improved Cancer Targeting

Journal of Oncology, Год журнала: 2020, Номер 2020, С. 1 - 16

Опубликована: Июль 13, 2020

The therapeutic efficacy of drugs is dependent upon the ability a drug to reach its target, and penetration into tumors limited by abnormal vasculature high interstitial pressure. Chemotherapy most common systemic treatment for cancer but can cause undesirable adverse effects, including toxicity bone marrow gastrointestinal system. Therefore, nanotechnology-based delivery systems have been developed reduce effects traditional chemotherapy enhancing selective retention in tumor tissues. A thorough knowledge physical properties (e.g., size, surface charge, shape, mechanical strength) chemical attributes nanoparticles crucial facilitate application nanotechnology biomedical applications. This review provides summary how be exploited improve efficacy. An ideal nanoparticle proposed at end this order guide future development improved targeting vivo.

Язык: Английский

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A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy

Advanced Materials, Год журнала: 2021, Номер 33(14)

Опубликована: Фев. 26, 2021

Abstract Cell‐membrane‐coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with multifunctionalities synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed further improve their immunotherapeutic efficacy. Herein, a polymer multicellular nanoengager (SPNE) for synergistic second‐near‐infrared‐window (NIR‐II) photothermal immunotherapy is reported. The consists an NIR‐II absorbing as core, which camouflaged fused derived from immunologically engineered tumor cells and dendritic (DCs) vaccine shell. In association high accumulation lymph nodes tumors, engagement ability SPNE enables effective cross‐interactions among cells, DCs, T leading augmented activation relative bare or tumor‐cell‐coated nanoparticles. Upon deep‐tissue penetrating photoirradiation, eradicates induces immunogenic death, eliciting anti‐tumor immunity. Such effect eventually inhibits growth, prevents metastasis procures immunological memory. Thus, this study presents general cell‐membrane‐coating approach develop photo‐immunotherapeutic agents therapy.

Язык: Английский

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Cell membrane-camouflaged nanoparticles as drug carriers for cancer therapy

Acta Biomaterialia, Год журнала: 2020, Номер 105, С. 1 - 14

Опубликована: Янв. 28, 2020

Язык: Английский

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Cell membrane-coated nanosized active targeted drug delivery systems homing to tumor cells: A review

Materials Science and Engineering C, Год журнала: 2019, Номер 106, С. 110298 - 110298

Опубликована: Окт. 13, 2019

Язык: Английский

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Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

Advanced Functional Materials, Год журнала: 2020, Номер 30(39)

Опубликована: Авг. 9, 2020

Abstract Surface modification of nanomaterials is essential for their biomedical applications owing to passive immune clearance and damage reticuloendothelial systems. Recently, a cell membrane‐coating technology has been proposed as an ideal approach modify its facile functionalized process good biocompatibility improving performances synthetic nanomaterials. Here, recent advances membrane‐coated are reviewed based on the main biological functions membrane in living cells. An overview introduced understand potential applications. Then, summarized, including physical barrier with selective permeability cellular communication via information transmission reception processes. Finally, perspectives challenges about discussed.

Язык: Английский

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Expandable Immunotherapeutic Nanoplatforms Engineered from Cytomembranes of Hybrid Cells Derived from Cancer and Dendritic Cells

Advanced Materials, Год журнала: 2019, Номер 31(18)

Опубликована: Март 25, 2019

Using the cytomembranes (FMs) of hybrid cells acquired from fusion cancer and dendritic (DCs), this study offers a biologically derived platform for combination immunotherapy traditional oncotherapy approaches. Due to immunoactivation implicated in cellular fusion, FMs can effectively express whole antigens immunological co-stimulatory molecules robust immunotherapy. share tumor's self-targeting character with parent cells. In bilateral tumor-bearing mouse models, FM-coated nanophotosensitizer causes durable immunoresponse inhibit rebound primary tumors post-nanophotosensitizer-induced photodynamic therapy (PDT). The FM-induced displays ultrahigh antitumor effects even comparable that PDT. On other hand, PDT toward enhances immunotherapy-caused regression irradiation-free distant tumors. Consequently, both are almost completely eliminated. This tumor-specific immunotherapy-based nanoplatform is potentially expandable multiple tumor types readily equipped diverse functions owing flexible nanoparticle options.

Язык: Английский

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