Metal–Organic Frameworks for Biomedical Applications

Small, Год журнала: 2020, Номер 16(10)

Опубликована: Фев. 6, 2020

Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes functional organic ligands through bonds, have attracted extensive research interest during the past decades. Due to unique features diverse compositions, facile synthesis, easy surface functionalization, high areas, adjustable porosity, tunable biocompatibility, MOFs been widely used in hydrogen/methane storage, catalysis, biological imaging sensing, drug delivery, desalination, gas separation, magnetic electronic devices, nonlinear optics, water vapor capture, etc. Notably, with rapid development synthetic methods functionalization strategies, smart MOF-based nanocomposites advanced bio-related properties designed fabricated meet growing demands MOF materials for biomedical applications. This work outlines synthesis recent advances fields, including cargo (drugs, nucleic acids, proteins, dyes) delivery cancer therapy, bioimaging, antimicrobial, biosensing, biocatalysis. The prospects challenges field also discussed.

Язык: Английский

---

The recent progress on metal–organic frameworks for phototherapy

Chemical Society Reviews, Год журнала: 2021, Номер 50(8), С. 5086 - 5125

Опубликована: Янв. 1, 2021

Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over world. The commonly used antibiotic therapy cannot effectively treat these within a short time, and also bring about adverse effects drug resistance immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) induce temperature increase, which leads death targeted cells. These two kinds killing strategies referred photodynamic (PDT) photothermal (PTT), respectively. So far, many photo-responsive have been developed. Among them, metal-organic framework (MOF) becoming one most promising materials because its structure chemical compositions be easily modulated achieve specific functions. MOFs intrinsic ability under rational design MOF construction, serve carrier therapeutic agents, owing tunable porosity. provide feasibility for various combined therapies targeting methods, improves efficiency phototherapy. In this review, we firstly investigated principles phototherapy, comprehensively summarized recent advances in PDT, PTT synergistic therapy, from construction modification. We expect that our demonstration will shed on future development field, it step closer clinical trials.

Язык: Английский

---

Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

Chemical Society Reviews, Год журнала: 2021, Номер 50(16), С. 9152 - 9201

Опубликована: Янв. 1, 2021

Photodynamic therapy (PDT) has been extensively investigated for decades tumor treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability.

Язык: Английский

---

Synergistic antibacterial strategy based on photodynamic therapy: Progress and perspectives

Chemical Engineering Journal, Год журнала: 2022, Номер 450, С. 138129 - 138129

Опубликована: Июль 16, 2022

Язык: Английский

---

Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine

Chemical Society Reviews, Год журнала: 2021, Номер 50(7), С. 4432 - 4483

Опубликована: Янв. 1, 2021

Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties widespread industrial use. In recent decades, accessibility, versatile reactivity, relative biocompatibility catalysed phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which been a major benefactor this emergence, as largely demonstrated by polydopamine polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms synthetic strategies PEN state-of-the-art provide timely comprehensive summary. review, we will focus on principles involved summarize use toolkit particle engineering bottom-up synthesis nanohybrid materials. Specifically, discuss attractive forces between phenolics complementary structural motifs confined systems synthesize high-quality products with controllable size, shape, composition, well surface chemistry function. Additionally, phenolic's numerous biosensing, bioimaging, disease treatment be highlighted. This review aims guidelines new scientists field serve an up-to-date compilation what has achieved area, while offering expert perspectives PEN's translational research.

Язык: Английский

---

Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

---

Multifunctional antimicrobial materials: From rational design to biomedical applications

Progress in Materials Science, Год журнала: 2021, Номер 125, С. 100887 - 100887

Опубликована: Ноя. 11, 2021

Язык: Английский

---

Antibacterial mechanisms and applications of metal-organic frameworks and their derived nanomaterials

Trends in Food Science & Technology, Год журнала: 2021, Номер 109, С. 413 - 434

Опубликована: Янв. 12, 2021

Язык: Английский

---

Recent Progress in Functional Materials for Selective Detection and Removal of Mercury(II) Ions

Advanced Functional Materials, Год журнала: 2020, Номер 31(1)

Опубликована: Сен. 18, 2020

Abstract Severe disease and environmental pollution derived from heavy metal ions has become one of the major problems in global public health. In particular, mercury(II) as type highly poisonous pollutant can destroy human metabolism, central nervous system, immune representing a critical threat to living systems. Therefore, exploitation new strategies for designing synthesizing eco‐friendly, efficient, economical materials selective detection removal Hg 2+ is great importance. Among various measures sensing, detection, mercury ions, advanced functional systems including nanomaterials, polymers, aggregation‐induced emission luminogens, porous have attracted considerable attention over past years due their capabilities real‐time rapid removal, anti‐interference, quick response, high selectivity, low limit detection. this review, some efficient techniques aqueous solutions using abovementioned are overviewed ways which these material used tackle problem also discussed.

Язык: Английский

---

Customizing nano-chitosan for sustainable drug delivery

Journal of Controlled Release, Год журнала: 2022, Номер 350, С. 175 - 192

Опубликована: Авг. 19, 2022

Язык: Английский

---