Advanced Materials,
Год журнала:
2023,
Номер
36(7)
Опубликована: Сен. 18, 2023
Microfluidics,
with
its
remarkable
capacity
to
manipulate
fluids
and
droplets
at
the
microscale,
has
emerged
as
a
powerful
platform
in
numerous
fields.
In
contrast
conventional
closed
microchannel
microfluidic
systems,
free-boundary
manufacturing
(FBMM)
processes
continuous
precursor
into
jets
or
relatively
spacious
environment.
FBMM
is
highly
regarded
for
superior
flexibility,
stability,
economy,
usability,
versatility
of
advanced
materials
architectures.
this
review,
comprehensive
overview
recent
advancements
provided,
encompassing
technical
principles,
material
manufacturing,
their
applications.
categorized
based
on
foundational
mechanisms,
primarily
comprising
hydrodynamics,
interface
effects,
acoustics,
electrohydrodynamic.
The
mechanisms
fluid
manipulation
are
thoroughly
discussed.
Additionally,
various
dimensions
ranging
from
zero-dimensional
three-dimensional,
well
diverse
applications
science,
biomedical
engineering,
engineering
presented.
Finally,
current
progress
summarized
future
challenges
prospected.
Overall,
review
highlights
significant
potential
tool
wide-ranging
Materials Horizons,
Год журнала:
2021,
Номер
9(3), С. 892 - 907
Опубликована: Ноя. 26, 2021
The
construction
of
artificial
cells
with
specific
cell-mimicking
functions
helps
to
explore
complex
biological
processes
and
cell
in
natural
systems
provides
an
insight
into
the
origins
life.
Bottom-up
methods
are
widely
used
for
engineering
based
on
vesicles
by
Abstract
Adhesion
to
many
kinds
of
surfaces,
including
biological
tissues,
is
important
in
fields
but
has
been
proved
be
extremely
challenging.
Furthermore,
peeling
from
strong
adhesion
needed
conditions,
sometimes
painful.
Herein,
a
mussel
inspired
hydrogel
developed
achieve
both
and
trigger‐detachment.
The
former
actualized
by
electrostatic
interactions,
covalent
bonds,
physical
interpenetration,
while
the
latter
triggered,
on‐demand,
through
combining
thixotropic
supramolecular
network
polymer
double
network.
results
experiments
show
that
can
adhere
various
material
surfaces
tissues.
Moreover,
triggered
shear
force,
non‐covalent
interactions
are
destroyed.
This
peeled
easily.
possible
mechanism
involved
discussed
proved.
work
will
bring
new
insight
into
electronic
engineering
tissue
repair
like
skin
care
for
premature
infants
burn
victims.
Lab on a Chip,
Год журнала:
2023,
Номер
23(5), С. 1192 - 1212
Опубликована: Янв. 1, 2023
Organoids/organs-on-a-chip
contribute
to
mimicking
intestinal
surface
topography,
microenvironment,
and
various
interactions,
providing
new
frontiers
of
pathophysiological
models.
Lab on a Chip,
Год журнала:
2024,
Номер
24(5), С. 996 - 1029
Опубликована: Янв. 1, 2024
A
molecular
robot,
which
is
a
system
comprised
of
one
or
more
machines
and
computers,
can
execute
sophisticated
tasks
in
many
fields
that
span
from
nanomedicine
to
green
nanotechnology.
The
core
parts
robots
are
fairly
consistent
always
include
(i)
body
encapsulate
machines,
(ii)
sensors
capture
signals,
(iii)
computers
make
decisions,
(iv)
actuators
perform
tasks.
This
review
aims
provide
an
overview
approaches
considerations
develop
robots.
We
first
introduce
the
basic
technologies
required
for
constructing
robots,
describe
recent
progress
towards
achieving
higher
functionality,
subsequently
discuss
current
challenges
outlook.
also
highlight
applications
sensing
biomarkers,
signal
communications
with
living
cells,
conversion
energy.
Although
still
their
infancy,
they
will
unquestionably
initiate
massive
change
biomedical
environmental
technology
not
too
distant
future.
ACS Applied Engineering Materials,
Год журнала:
2024,
Номер
2(12), С. 2758 - 2770
Опубликована: Март 21, 2024
This
review
explores
the
cutting-edge
development
of
multicompartment
synthetic
vesicles
designed
for
artificial
cell
applications,
drawing
inspiration
from
complex
compartmentalization
inherent
in
living
cells.
It
delves
into
recent
advancements
engineering
equipped
with
both
membranous
and
membraneless
organelles
(vesicles-in-vesicles
coacervates-in-vesicles),
offering
a
detailed
examination
methodologies
materials
employed.
paper
highlights
critical
role
these
simulating
cellular
microenvironments
functions,
facilitating
spatial
temporal
segregation
biochemical
processes,
such
as
signal
transduction,
gene
expression,
ATP
synthesis,
energy
production.
Moreover,
this
outlines
potential
future
directions,
emphasizing
importance
evolution
cells
focus
on
their
application
creating
more
sophisticated
biomimetic
systems.
Abstract
Microfluidic
devices
have
become
a
vastly
popular
technology,
particularly
because
of
the
advantages
they
offer
over
their
traditional
counterparts.
They
such
wide
range
uses
and
can
make
complex
tasks
quite
efficient.
One
area
research
or
work
that
has
benefited
greatly
from
use
microfluidics
is
biosensing,
where
microfluidic
chips
are
integrated
into
biosensor
setups.
There
growing
numbers
applications
in
this
as
researchers
look
for
efficient
ways
to
tackle
disease
diagnostics
drug
discovery,
which
critical
era
recurring
pandemics.
In
work,
authors
review
integration
with
biosensors,
well
food
security,
molecular
biology,
cell
diagnostics,
at
some
most
recent
these
areas.
The
covers
including
cellular
life
science
research,
agro-food
processing,
immunological
veterinarian
diagnostics.
Microfluidics
field
combines
fundamental
laws
physics
chemistry
solve
miniaturization
problems
involving
fluids
nanoscale
microscale,
such,
also
examine
mathematical
concepts
biosensing.
relatively
new
technologies
great
potential
terms
applications.
Advanced Materials,
Год журнала:
2020,
Номер
32(43)
Опубликована: Сен. 21, 2020
Synthetic
cells
have
a
major
role
in
gaining
insight
into
the
complex
biological
processes
of
living
cells;
they
also
give
rise
to
range
emerging
applications
from
gene
delivery
enzymatic
nanoreactors.
Living
rely
on
compartmentalization
orchestrate
reaction
networks
for
specialized
and
coordinated
functions.
Principally,
has
been
an
essential
engineering
theme
constructing
cell-mimicking
systems.
Here,
efforts
engineer
liquid-liquid
interfaces
multiphase
systems
membrane-bounded
membraneless
compartments,
which
include
lipid
vesicles,
polymer
colloidosomes,
hybrids,
coacervate
droplets,
are
summarized.
Examples
provided
how
these
compartments
designed
imitate
behaviors
or
machinery,
including
molecule
trafficking,
growth,
fusion,
energy
conversion,
intercellular
communication,
adaptivity.
Subsequently,
state-of-art
cell-inspired
synthetic
discussed.
Apart
being
simplified
cell
models
bridging
gap
between
nonliving
matter
cellular
life,
utilized
as
intracellular
vehicles
nuclei
acids
nanoreactors
biochemical
synthesis.
Finally,
key
challenges
future
directions
achieving
full
potential
highlighted.
