Free‐Boundary Microfluidic Platform for Advanced Materials Manufacturing and Applications DOI
Zhiqiang Zhu, T. Chen,

Fangsheng Huang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(7)

Published: Sept. 18, 2023

Microfluidics, with its remarkable capacity to manipulate fluids and droplets at the microscale, has emerged as a powerful platform in numerous fields. In contrast conventional closed microchannel microfluidic systems, free-boundary manufacturing (FBMM) processes continuous precursor into jets or relatively spacious environment. FBMM is highly regarded for superior flexibility, stability, economy, usability, versatility of advanced materials architectures. this review, comprehensive overview recent advancements provided, encompassing technical principles, material manufacturing, their applications. categorized based on foundational mechanisms, primarily comprising hydrodynamics, interface effects, acoustics, electrohydrodynamic. The mechanisms fluid manipulation are thoroughly discussed. Additionally, various dimensions ranging from zero-dimensional three-dimensional, well diverse applications science, biomedical engineering, engineering presented. Finally, current progress summarized future challenges prospected. Overall, review highlights significant potential tool wide-ranging

Language: Английский

Vesicle-based artificial cells: materials, construction methods and applications DOI Creative Commons
Yao Lu, Giulia Allegri, Jurriaan Huskens

et al.

Materials Horizons, Journal Year: 2021, Volume and Issue: 9(3), P. 892 - 907

Published: Nov. 26, 2021

The construction of artificial cells with specific cell-mimicking functions helps to explore complex biological processes and cell in natural systems provides an insight into the origins life. Bottom-up methods are widely used for engineering based on vesicles by

Language: Английский

Citations

70

Spatial confinement of multi-enzyme for cascade catalysis in cell-inspired all-aqueous multicompartmental microcapsules DOI
Qingli Qu, Xiaoli Zhang,

Anquan Yang

et al.

Journal of Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 626, P. 768 - 774

Published: June 27, 2022

Language: Английский

Citations

52

Mussel Inspired Trigger‐Detachable Adhesive Hydrogel DOI
Chenlong Wang, Xiaohan Gao, Feng Zhang

et al.

Small, Journal Year: 2022, Volume and Issue: 18(21)

Published: April 23, 2022

Abstract Adhesion to many kinds of surfaces, including biological tissues, is important in fields but has been proved be extremely challenging. Furthermore, peeling from strong adhesion needed conditions, sometimes painful. Herein, a mussel inspired hydrogel developed achieve both and trigger‐detachment. The former actualized by electrostatic interactions, covalent bonds, physical interpenetration, while the latter triggered, on‐demand, through combining thixotropic supramolecular network polymer double network. results experiments show that can adhere various material surfaces tissues. Moreover, triggered shear force, non‐covalent interactions are destroyed. This peeled easily. possible mechanism involved discussed proved. work will bring new insight into electronic engineering tissue repair like skin care for premature infants burn victims.

Language: Английский

Citations

41

Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models DOI Open Access
Lei Wu, Yongjian Ai, Ruoxiao Xie

et al.

Lab on a Chip, Journal Year: 2023, Volume and Issue: 23(5), P. 1192 - 1212

Published: Jan. 1, 2023

Organoids/organs-on-a-chip contribute to mimicking intestinal surface topography, microenvironment, and various interactions, providing new frontiers of pathophysiological models.

Language: Английский

Citations

38

Microfluidics-Based Nanobiosensors for Healthcare Monitoring DOI Open Access
Monika Kumari, Verruchi Gupta, Natish Kumar

et al.

Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 66(3), P. 378 - 401

Published: May 11, 2023

Language: Английский

Citations

30

Lipid vesicle-based molecular robots DOI Creative Commons
Zugui Peng,

Shoji Iwabuchi,

Kayano Izumi

et al.

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 996 - 1029

Published: Jan. 1, 2024

A molecular robot, which is a system comprised of one or more machines and computers, can execute sophisticated tasks in many fields that span from nanomedicine to green nanotechnology. The core parts robots are fairly consistent always include (i) body encapsulate machines, (ii) sensors capture signals, (iii) computers make decisions, (iv) actuators perform tasks. This review aims provide an overview approaches considerations develop robots. We first introduce the basic technologies required for constructing robots, describe recent progress towards achieving higher functionality, subsequently discuss current challenges outlook. also highlight applications sensing biomarkers, signal communications with living cells, conversion energy. Although still their infancy, they will unquestionably initiate massive change biomedical environmental technology not too distant future.

Language: Английский

Citations

10

Multicompartment Synthetic Vesicles for Artificial Cell Applications DOI

Jooyong Shin,

Yeongseon Jang

ACS Applied Engineering Materials, Journal Year: 2024, Volume and Issue: 2(12), P. 2758 - 2770

Published: March 21, 2024

This review explores the cutting-edge development of multicompartment synthetic vesicles designed for artificial cell applications, drawing inspiration from complex compartmentalization inherent in living cells. It delves into recent advancements engineering equipped with both membranous and membraneless organelles (vesicles-in-vesicles coacervates-in-vesicles), offering a detailed examination methodologies materials employed. paper highlights critical role these simulating cellular microenvironments functions, facilitating spatial temporal segregation biochemical processes, such as signal transduction, gene expression, ATP synthesis, energy production. Moreover, this outlines potential future directions, emphasizing importance evolution cells focus on their application creating more sophisticated biomimetic systems.

Language: Английский

Citations

10

Applications of microfluidics in biosensing DOI Creative Commons

Masindi Sekhwama,

Kelvin Mpofu, Sudesh Sivarasu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(6)

Published: May 31, 2024

Abstract Microfluidic devices have become a vastly popular technology, particularly because of the advantages they offer over their traditional counterparts. They such wide range uses and can make complex tasks quite efficient. One area research or work that has benefited greatly from use microfluidics is biosensing, where microfluidic chips are integrated into biosensor setups. There growing numbers applications in this as researchers look for efficient ways to tackle disease diagnostics drug discovery, which critical era recurring pandemics. In work, authors review integration with biosensors, well food security, molecular biology, cell diagnostics, at some most recent these areas. The covers including cellular life science research, agro-food processing, immunological veterinarian diagnostics. Microfluidics field combines fundamental laws physics chemistry solve miniaturization problems involving fluids nanoscale microscale, such, also examine mathematical concepts biosensing. relatively new technologies great potential terms applications.

Language: Английский

Citations

9

A comprehensive understanding on droplets DOI
Gang Chen, Guanhua Lin

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103490 - 103490

Published: March 1, 2025

Language: Английский

Citations

1

Interface Engineering in Multiphase Systems toward Synthetic Cells and Organelles: From Soft Matter Fundamentals to Biomedical Applications DOI
Zhou Liu, Wen Zhou, Qi Cheng

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(43)

Published: Sept. 21, 2020

Synthetic cells have a major role in gaining insight into the complex biological processes of living cells; they also give rise to range emerging applications from gene delivery enzymatic nanoreactors. Living rely on compartmentalization orchestrate reaction networks for specialized and coordinated functions. Principally, has been an essential engineering theme constructing cell-mimicking systems. Here, efforts engineer liquid-liquid interfaces multiphase systems membrane-bounded membraneless compartments, which include lipid vesicles, polymer colloidosomes, hybrids, coacervate droplets, are summarized. Examples provided how these compartments designed imitate behaviors or machinery, including molecule trafficking, growth, fusion, energy conversion, intercellular communication, adaptivity. Subsequently, state-of-art cell-inspired synthetic discussed. Apart being simplified cell models bridging gap between nonliving matter cellular life, utilized as intracellular vehicles nuclei acids nanoreactors biochemical synthesis. Finally, key challenges future directions achieving full potential highlighted.

Language: Английский

Citations

61